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    System for managing bulk liquids and/or solids
    232.
    发明授权
    System for managing bulk liquids and/or solids 有权
    用于管理散装液体和/或固体的系统

    公开(公告)号：US09285262B2

    公开(公告)日：2016-03-15

    申请号：US14103992

    申请日：2013-12-12

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Daniel Kneubuehl ,  Martin Lustenberger ,  Christian Marty ,  Emanuel Masel ,  André Peter ,  Markus Troxler

    IPC: G01G17/04 ,  G01N35/10 ,  G01F23/20 ,  G01G15/00 ,  G01G3/16 ,  G01N35/00

    CPC classification number: G01G15/006 ,  G01G3/16 ,  G01G17/04 ,  G01N35/1002 ,  G01N2035/00217

    Abstract: A system for managing of bulk liquids and/or bulk solids for in-vitro diagnostics is disclosed. The system comprises a sample processing unit and a container unit for receiving a supply container supplying the sample processing unit with a bulk liquid/solid and/or a waste container receiving waste from the sample processing unit. The system further comprises a weight measuring device comprising a loading plate, a base and a force measuring cell. The force measuring cell comprises a sensor comprising a tensioned sensor wire. The loading plate is biased with respect to the base by a weight applied to the loading plate by a container and to transfer force to the force measuring cell. The transferred force causes a deformation of the force measuring cell and a change in tension of the sensor wire causing a change in vibrational frequency resulting in a signal indicative of the weight of the container.

    Abstract translation: 公开了一种用于管理用于体外诊断的散装液体和/或散装固体的系统。 该系统包括样品处理单元和容器单元，用于接收向样品处理单元供应大量液体/固体的供应容器和/或从样品处理单元接收废物的废物容器。 该系统还包括重量测量装置，其包括装载板，底座和力测量单元。 力测量单元包括传感器，其包括张紧的传感器线。 装载板通过由容器施加到装载板的重量相对于基座偏置并且将力传递到力测量单元。 传递的力导致力测量单元的变形和传感器线的张力变化，导致振动频率的变化，导致指示容器重量的信号。

    IDENTIFICATION, AUTHENTICATION, AND AUTHORIZATION METHOD IN A LABORATORY SYSTEM
    233.
    发明申请
    IDENTIFICATION, AUTHENTICATION, AND AUTHORIZATION METHOD IN A LABORATORY SYSTEM 审中-公开
    实验室系统中的识别，认证和授权方法

    公开(公告)号：US20160065590A1

    公开(公告)日：2016-03-03

    申请号：US14827790

    申请日：2015-08-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Lothar Gramelspacher ,  Andrzej Knafel ,  Anton Steimle

    IPC: H04L29/06 ,  H04L9/32

    CPC classification number: H04L63/123 ,  G06F21/335 ,  G06F21/34 ,  G16H10/40 ,  H04L9/3234 ,  H04L9/3247 ,  H04L63/0428 ,  H04L63/0807 ,  H04L63/0853 ,  H04L63/108 ,  H04L2209/24 ,  H04L2209/72 ,  H04L2209/805 ,  H04L2463/082

    Abstract: An identification, authentication and authorization method in a laboratory system is presented. The system comprises at least one laboratory device. The method comprises receiving identification data identifying a user; receiving identity confirmation data to authenticate the user; and generating authentication data upon successful authentication of the user. The authentication data is configured to enable authentication of the user based on only the identification data during a validity time period without repeated receipt of the identity confirmation data. The method further comprises receiving the identification data by an identification unit; validating the authentication data corresponding to the identification data comprising the step of verifying non-expiry of the validity time period; and granting authorization to the user for the laboratory device upon successful validation of the authentication data.

    Abstract translation: 介绍了实验室系统中的识别，认证和授权方法。 该系统包括至少一个实验室装置。 该方法包括接收识别用户的识别数据; 接收身份确认数据以验证用户; 以及在用户成功认证时生成认证数据。 认证数据被配置为仅在有效时间段内仅基于识别数据进行用户认证，而不重复接收到身份确认数据。 该方法还包括由识别单元接收识别数据; 验证对应于所述识别数据的认证数据，所述认证数据包括验证所述有效期限的无效的步骤; 并且在认证数据成功验证之后授予实验室设备的用户的授权。

    LABORATORY SAMPLE DISTRIBUTION SYSTEM, LABORATORY SYSTEM AND METHOD OF OPERATING
    235.
    发明申请
    LABORATORY SAMPLE DISTRIBUTION SYSTEM, LABORATORY SYSTEM AND METHOD OF OPERATING 有权
    实验室样品分配系统，实验室系统及操作方法

    公开(公告)号：US20160054344A1

    公开(公告)日：2016-02-25

    申请号：US14920097

    申请日：2015-10-22

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Michael Heise ,  Hans Schneider

    IPC: G01N35/04 ,  B65G54/02 ,  B65G37/00

    CPC classification number: G01N35/04 ,  B65G37/00 ,  B65G54/02 ,  G01N2035/0465 ,  G01N2035/0477 ,  Y10T436/114165

    Abstract: A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container containing a sample. The system further comprises a transport plane to carry the multiple container carriers and a plurality of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. The system also comprises at least one transfer device to transfer a sample item, wherein the sample item is a container carrier, a sample container, part of the sample and/or the complete sample, between the transport plane and a laboratory station such as, for example, a pre-analytical, an analytical and/or a post-analytical station.

    Abstract translation: 提出了实验室样品分配系统。 实验室样品分配系统包括多个容器载体。 容器载体各自包括至少一个磁性活动装置，例如至少一个永久磁铁，并携带含有样品的样品容器。 该系统还包括一个运送平面，用于承载多个集装箱运送装置和多个固定地布置在运输平面下方的电磁致动器。 电磁致动器通过向容器载体施加磁力而将容器载体移动到输送平面的顶部。 该系统还包括至少一个转运装置，用于传送样品物品，其中样品物品是运输平面和实验室之间的容器载体，样品容器，样品的一部分和/或完整的样品， 例如，预分析，分析和/或分析后站。

    CONTROLLING AN ANALYSIS SYSTEM OF BIOLOGICAL SAMPLES
    236.
    发明申请
    CONTROLLING AN ANALYSIS SYSTEM OF BIOLOGICAL SAMPLES 有权

    公开(公告)号：US20160048691A1

    公开(公告)日：2016-02-18

    申请号：US14920255

    申请日：2015-10-22

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Lothar Gramelspacher ,  Andrzej Knafel

    IPC: G06F21/60 ,  G06F21/31

    CPC classification number: G06F21/602 ,  A61B5/7285 ,  G06F19/00 ,  G06F21/31 ,  G06F21/335 ,  G06F21/36 ,  G16H10/60

    Abstract: A method for controlling an analysis system is presented. The method comprises receiving, by an encryption unit, authentication data of a user. In the case of a successful authentication, a user-specific security code is generated by the encryption unit. The security code is outputted by the encryption unit to the authenticated user. The security code and the user-ID are received by an authentication unit coupled to the analysis system via a user-interface coupled to the authentication unit. The security code is decrypted by the authentication unit. If the decrypted security code matches with the user-ID, the user is authenticated at the authentication unit and an authentication signal is generated by the authentication unit for permitting the user to initialize at least one function of the analysis system.

    T7 RNA POLYMERASE VARIANTS WITH CYSTEINE-SERINE SUBSTITUTIONS
    238.
    发明申请
    T7 RNA POLYMERASE VARIANTS WITH CYSTEINE-SERINE SUBSTITUTIONS 有权
    T7 RNA聚合酶与CYSTEINE-丝氨酸取代的变体

    公开(公告)号：US20160010069A1

    公开(公告)日：2016-01-14

    申请号：US14872392

    申请日：2015-10-01

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Michael Greif ,  Christian Rudolph ,  Manfred Schmidt ,  Harald Sobek ,  Johann-Peter Thalhofer

    IPC: C12N9/12

    CPC classification number: C12N9/1247 ,  C12Y207/07006

    Abstract: The present disclosure provide novel variants of T7 RNA polymerase. Embodiments of T7 variants, according to the instant invention, include a Cysteine-Serine substitution on position 723 of the amino acid sequence of the T7 polypeptide. Embodiments of T7 variants according to the instant invention have a DNA-dependent RNA polymerase enzymatic activity and a reduced tendency to form intramolecular homodimers by way of oxidizing thiol groups. The amino acid substitutions within the T7 variants disclosed herein impact minimally, if at all, the RNA polymerase activity of the T7 polypeptide. Further, the mutations of the disclosed embodiments may optionally be combined with mutations which provide enhanced thermostability compared to the wild-type reference.

    Abstract translation: 本公开提供了T7RNA聚合酶的新变体。 根据本发明的T7变体的实施方案包括T7多肽的氨基酸序列的位置723上的半胱氨酸 - 丝氨酸取代。 根据本发明的T7变体的实施方案具有DNA依赖性RNA聚合酶酶活性，并且通过氧化硫醇基形成分子内同型二聚体的趋势降低。 本文公开的T7变体内的氨基酸取代最小程度地影响T7多肽的RNA聚合酶活性。 此外，所公开的实施方案的突变可以任选地与与野生型参考物相比提供增强的热稳定性的突变组合。

    Communication protocol improvement to recover data from a continuous glucose monitor
    239.
    发明授权
    Communication protocol improvement to recover data from a continuous glucose monitor 有权
    通信协议改进，从连续葡萄糖监测器恢复数据

    公开(公告)号：US09226702B2

    公开(公告)日：2016-01-05

    申请号：US13650160

    申请日：2012-10-12

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Clint A. Ecoff ,  Sheldon A. White

    IPC: G08B1/08 ,  A61M1/00 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00

    CPC classification number: A61B5/14532 ,  A61B5/0015 ,  A61B5/7232 ,  G06F19/3418

    Abstract: Data transmissions between medical devices are governed by various communication protocols. For example, blood glucose measures may be retrieved wirelessly from a continuous glucose monitor in accordance with the ANT wireless communication protocol. Smaller data packets are preferably transferred in a standard data transfer mode which is optimized for speed and power management; whereas, larger data packets are transferred in a file sharing mode. Techniques are presented to address recovering data lost during the standard data transfer mode in an efficient manner and preferably without the use of the file sharing mode.

    Abstract translation: 医疗设备之间的数据传输由各种通信协议控制。 例如，可以根据ANT无线通信协议从连续葡萄糖监测器无线地检索血糖测量。 更小的数据分组优选地以针对速度和功率管理进行了优化的标准数据传输模式传输; 而较大的数据分组则以文件共享模式传输。 提出技术来以有效的方式解决在标准数据传输模式期间丢失的数据，优选地不使用文件共享模式。

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