公开(公告)号：US20230003742A1

公开(公告)日：2023-01-05

申请号：US17781706

申请日：2020-12-10

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shani Shenhar-Tsarfaty ,  Shlomo Avraham Berliner ,  Ori Rogowski ,  Eyal Fisher ,  Adi Silberman ,  Yishai Levin

IPC: G01N33/68

Abstract: The invention provides assays and methods for detecting and monitoring systemic inflammation Particularly, the invention in embodiments thereof relates to the use of urinary biomarkers for non-invasive determination of the level of inflammation.

公开(公告)号：US20220372145A1

公开(公告)日：2022-11-24

申请号：US17876641

申请日：2022-07-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Yonatan KATZENELENBOGEN ,  Adam YALIN ,  Fadi SHEBAN

IPC: C07K16/28 ,  C07K16/30

Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.

公开(公告)号：US20220370517A1

公开(公告)日：2022-11-24

申请号：US17854034

申请日：2022-06-30

Applicant: Ichilov Tech Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Jacob MASHIAH ,  Nitsan MAHARSHAK

IPC: A61K35/741 ,  A61K35/745 ,  A61K35/742 ,  A61K35/24 ,  A61P17/00

Abstract: A method of treating atopic dermatitis (AD) in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of at least two species of bacteria.

公开(公告)号：US20220362329A1

公开(公告)日：2022-11-17

申请号：US17875551

申请日：2022-07-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Ido AMIT ,  Aleksandra Anna KOLODZIEJCZYK

IPC: A61K38/14 ,  A61P1/16 ,  A61K31/43 ,  A61K31/7036 ,  A61K31/4164

Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.

公开(公告)号：US11492405B2

公开(公告)日：2022-11-08

申请号：US16728642

申请日：2019-12-27

Applicant: Yeda Research and Development Co. Ltd

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61P25/16 ,  A61P25/28 ,  A61K31/4155 ,  A61K31/7068 ,  A61K31/404 ,  A61K33/36 ,  A61K45/06 ,  A61P37/06 ,  A61P27/02 ,  A61K39/00

Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

公开(公告)号：US11480568B2

公开(公告)日：2022-10-25

申请号：US16133295

申请日：2018-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi-Brook ,  Pennina Safer ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/577

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US11471430B2

公开(公告)日：2022-10-18

申请号：US17261255

申请日：2019-07-17

Applicant: Yeda Research and Development Co. Ltd. ,  University of Duisburg-Essen

Inventor： Anthony H. Futerman ,  Tammar Joseph ,  Walter A. Shaw ,  Stephen W. Burgess ,  Shengrong Li

IPC: A61K31/167 ,  A61K31/133 ,  A61K31/164

Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

公开(公告)号：US20220265696A1

公开(公告)日：2022-08-25

申请号：US17734199

申请日：2022-05-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  A61K31/713 ,  C12Q1/6883 ,  C12N15/113 ,  A61K48/00

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20220260819A1

公开(公告)日：2022-08-18

申请号：US17624344

申请日：2020-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Dan ORON ,  Uri ROSSMAN ,  Ron TENNE ,  Yonina C. ELDAR

IPC: G02B21/00

Abstract: A method of generating an image of a sample is provided. The method comprises providing a plurality of photon detectors, scanning the sample with an excitation beam over a predetermined time period, the detectors receiving photons emitted by the sample due to the excitation during the time period. A plurality of intensity images associated with each of the detectors are generated, each being proportional to the mean number of photons detected per unit time. A plurality of correlation images associated with each combination of two of the detectors are generated, each of the correlation images being proportional to the variance of the distribution of detected photons per unit time. The image of the sample is generated using joint sparse recovery from the plurality of intensity and correlation images, wherein the intensity and correlation images have common support.

公开(公告)号：US11412700B2

公开(公告)日：2022-08-16

申请号：US17008875

申请日：2020-09-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph Aharoni ,  Prashant Sonawane ,  Maxim Itkin

IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.