公开(公告)号：US09358153B2

公开(公告)日：2016-06-07

申请号：US13868764

申请日：2013-04-23

Applicant: ZOLL Circulation Inc.

Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

公开(公告)号：US09283110B2

公开(公告)日：2016-03-15

申请号：US13622104

申请日：2012-09-18

Applicant: ZOLL CIRCULATION, INC.

Inventor： Alex L. Lim ,  Venkata Vishnu Gurukula ,  Jeremy T. Dabrowiak ,  Richard A. Helkowski

IPC: A61F7/12 ,  A61B18/02 ,  A61F7/00

CPC classification number: A61F7/12 ,  A61F7/0085 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0094 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/00 ,  A61M2025/0004 ,  A61M2205/18 ,  A61M2205/3368

Abstract: A catheter has an inner sleeve through which refrigerant circulates to and from a source of refrigerant. The catheter also has an outer sleeve surrounding the inner sleeve, including a distal end thereof. The outer sleeve is filled with a frozen biocompatible substance. The refrigerant is separated from the biocompatible substance by one or more walls of the inner sleeve such that the refrigerant is isolated from a patient in whom the catheter is positioned by both the inner sleeve and the frozen biocompatible substance. The refrigerant circulates through the catheter when the catheter is positioned in the patient to maintain the biocompatible substance frozen as heat is transferred from the patient to the biocompatible substance.

Abstract translation: 导管具有内套筒，制冷剂通过该内套筒从制冷剂源流出。 导管还具有围绕内套筒的外套筒，包括其远端。 外套筒装有冷冻的生物相容性物质。 制冷剂通过内套筒的一个或多个壁与生物相容性物质分离，使得制冷剂与内套管和冷冻生物相容性物质由导管定位的患者隔离。 当导管位于患者体内时，制冷剂通过导管循环，以便当热量从患者转移到生物相容性物质时，使生物相容性物质保持冷冻。

公开(公告)号：US20160022955A1

公开(公告)日：2016-01-28

申请号：US14878372

申请日：2015-10-08

Applicant: ZOLL CIRCULATION, INC.

Inventor： Blair D. Walker ,  Scott M. Evans ,  David P. Balding ,  Peter Barker

IPC: A61M25/00 ,  A61F7/12

CPC classification number: A61F7/12 ,  A61B2017/00084 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M25/002 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/02 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0036 ,  A61M2025/1013 ,  A61M2205/36 ,  A61M2205/366

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract translation: 一套零件包括使用具有热交换元件的中心静脉导管的系统和用于控制患者体温的说明书。 中心静脉导管设置有一个或多个腔，用于提供对患者的中央血液供应的通路，以及用于将热交换流体传递到热交换元件的附加腔。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元。 管组在中央静脉管路和温度控制单元之间输送热交换流体，其中泵用于将流体循环在系统中的封闭流体回路中。

公开(公告)号：US09241827B2

公开(公告)日：2016-01-26

申请号：US13653648

申请日：2012-10-17

Applicant: Zoll Circulation, Inc.

Inventor： Alex L. Lim ,  Masouneh Mafi ,  Venkata Vishnu Gurukula

IPC: A61F7/12 ,  A61M25/10 ,  A61F7/00

CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0091 ,  A61F2007/126

Abstract: A catheter has a series of hollow loops arranged along a tube for carrying working fluid from a heat exchange system to exchange heat with a patient in whom the catheter is advanced. The loops when inflated are transverse to the catheter axis and parallel to each other, and circumscribe a hollow passageway through which blood can flow. Blood also flows around the outer perimeters of the loops.

Abstract translation: 导管具有沿着管布置的一系列中空环，用于承载来自热交换系统的工作流体，以与导管进入的患者进行热交换。 当充气时的环横向于导管轴线并且彼此平行，并且环绕血液可以流过的中空通道。 血液也流过环路的外围。

公开(公告)号：US20150230974A1

公开(公告)日：2015-08-20

申请号：US14180655

申请日：2014-02-14

Applicant: Zoll Circulation, Inc.

Inventor： Christoph Matthias Pistor ,  Jeremy Thomas Dabrowiak ,  Craig Wendell Pendry ,  Christo Pamichev

IPC: A61F7/00 ,  A61F7/10

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes along the sides of which are disposed inlet and outlet tubes. Working fluid from the catheter is directed from the inlet tube between the membranes to the outlet tube. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract translation: 用于血管内热交换导管的工作流体盒包括一个保持两个紧密间隔的方形聚合物膜的框架，其侧面设有入口和出口管。 来自导管的工作流体从膜之间的入口管引导到出口管。 盒子紧密地接收在两个制冷剂冷板之间，以与工作流体交换热量，工作流体循环回到导管。

公开(公告)号：US20150223974A1

公开(公告)日：2015-08-13

申请号：US14276202

申请日：2014-05-13

Applicant: Zoll Circulation, Inc.

Inventor： JEREMY THOMAS DABROWIAK ,  Eric Peterson

IPC: A61F7/10 ,  F28F3/12 ,  F25B1/00

CPC classification number: F28F3/12 ,  A61F7/0085 ,  A61F7/02 ,  A61F2007/0056 ,  A61F2007/126 ,  F25B39/02 ,  F28D9/0043

Abstract: A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad includes a working fluid that circulates between the catheter or pad and a fluid cassette, and a refrigerant system that flows against the outer sides of cold plates between which the cassette is disposed. An outer wall of the system is transparent so that a person can view the refrigerant as it circulates, ensuring proper operation.

Abstract translation: 用于与来自血管内热交换导管或外部热交换垫的工作流体进行热交换的热交换系统包括在导管或垫与流体盒之间循环的工作流体，以及流过冷的外侧的制冷剂系统 在其间设置盒的板。 系统的外壁是透明的，以便人们可以在制冷剂循环时观察制冷剂，确保正常运行。

公开(公告)号：US09078800B2

公开(公告)日：2015-07-14

申请号：US14196937

申请日：2014-03-04

Applicant: ZOLL Circulation, Inc.

Inventor： Paul Q. Escudero ,  Gregory W. Hall

IPC: A61H31/00

CPC classification number: A61H31/00 ,  A61H31/005 ,  A61H31/006 ,  A61H31/008 ,  A61H2031/003 ,  A61H2201/5007 ,  Y10S601/06 ,  Y10S601/20

Abstract: A compression belt cartridge for use with chest compression devices. The compression belt cartridge has a double-oar shaped belt and a cover plate through which the belt is threaded. The cover plate is provided with hooks and snap latches that fit into a belt drive platform. The cover plate is sized and dimensioned to fit within only selected platforms. The belt attaches to the means for tightening the belt via a spline attached to the belt. The means for tightening a belt then repetitively tightens the belt, thereby accomplishing chest compressions.

Abstract translation: 一种用于胸部按压装置的压缩带盒。 压缩带盒具有双瓣形带和带板穿过的盖板。 盖板设有配合在皮带传动平台上的钩和卡扣。 盖板的尺寸和尺寸适合于仅选择的平台。 带子通过连接在皮带上的花键连接到用于紧固皮带的装置。 用于收紧皮带的装置然后重复地收紧皮带，从而完成胸部按压。

公开(公告)号：US20140333366A1

公开(公告)日：2014-11-13

申请号：US14281653

申请日：2014-05-19

Applicant: Zoll Circulation, Inc.

Inventor： David Deam

IPC: H03K17/30 ,  H02J7/00

CPC classification number: H03K17/302 ,  H02J7/0031 ,  H02J7/0036 ,  H02J7/0057 ,  H02J7/047 ,  H02J2007/0059 ,  H02M1/08 ,  H02M1/36 ,  H03K2217/0027 ,  H03K2217/0054 ,  H03K2217/0081 ,  Y10T307/50

Abstract: A boost converter for driving the gate of n-channel MOSFET power devices is described. The boost converter includes a monitoring circuit and a kick start circuit to quickly bring the boost converter online when required to drive the MOSFET on.

Abstract translation: 描述了用于驱动n沟道MOSFET功率器件的栅极的升压转换器。 升压转换器包括监控电路和踢脚启动电路，以便在需要驱动MOSFET时快速使升压转换器处于在线状态。

公开(公告)号：US20140303531A1

公开(公告)日：2014-10-09

申请号：US14309724

申请日：2014-06-19

Applicant: ZOLL Circulation, Inc.

Inventor： Bob H. Katz ,  Timothy R. Dalbec ,  Gregory W. Hall

IPC: A61H31/00

CPC classification number: A61H31/00 ,  A61H31/005 ,  A61H31/006 ,  A61H31/008 ,  A61H2201/0173 ,  A61H2201/5007 ,  Y10S601/06 ,  Y10S601/20

Abstract: Safety mechanisms for compression belt cartridges used in chest compression devices. The safety mechanisms include a breakable link, liner socks, belt guards and a rapid-release connector. The breakable link ensures that unsafe belt tension will not occur. The liner socks protect the patient from friction and contain the breakable link. The belt guards protect foreign objects from entering the belt drive platform. The rapid-release connector allows the belt to be removed safely even during compressions.

Abstract translation: 用于胸部压缩装置的压缩皮带筒的安全机构。 安全机构包括可拆卸连杆，衬垫袜，皮带护罩和快速释放连接器。 可拆卸的连接确保不会发生不安全的皮带张力。 衬垫袜子可以保护患者免受摩擦并容纳易碎的环节。 皮带保护罩可防止异物进入皮带传动平台。 快速释放连接器允许安全地拆卸皮带，即使在按压期间。

公开(公告)号：US20140151017A1

公开(公告)日：2014-06-05

申请号：US14175386

申请日：2014-02-07

Applicant: Zoll Circulation, Inc.

Inventor： Wayne Noda ,  Stelica Stelea

IPC: A61F7/12

Abstract: A cooling system for an indwelling heat exchange catheter includes a heat exchange bath that is configured to receive a conduit that carries saline to and from the catheter. A heating/cooling fluid is in the bath and exchanges heat with the saline. The heating/cooling fluid flows through a heat exchanger that includes a refrigerant and two variable speed DC compressor for removing heat from the refrigerant. A gear pump circulates the working fluid to and from the catheter and is removably engaged with a pump support platform.