EFFECT OF GB1 DOMAIN FUSION ON UPREGULATION OF RECOMBINANT PROTEIN EXPRESSION IN PLANT

    公开(公告)号:US20250011376A1

    公开(公告)日:2025-01-09

    申请号:US18708261

    申请日:2022-09-15

    Abstract: The present invention relates to a GB1 domain fusion structure for upregulating recombinant protein expression in plants and, more specifically, to a GB1 domain fusion structure in which the GB1 domain of Streptococcus-derived protein G is fused with a target protein to be expressed in an upregulated manner, and a method for upregulating expression of a recombinant protein by using same. The present invention can bring about a reduced risk of contamination by pathogens and a high production yield, compared to the case of employing animal cells or microbes conventionally established to produce recombinant proteins, and a remarkable improvement in recombinant protein output, compared to the conventional case of employing plants. Thus, the present invention has several advantages in terms of quality and economy and thus can be a very competitive production method in the commercial production of recombinant proteins.

    Semiconductor device implementing physically unclonable function

    公开(公告)号:US12166868B2

    公开(公告)日:2024-12-10

    申请号:US17736986

    申请日:2022-05-04

    Abstract: An exemplary embodiment of the present disclosure provides a physically unclonable function (PUF) cell capable of exhibiting a stable performance and showing an excellent repeatability while being less affected by environmental factors such as a noise, temperature, and bias voltage. The PUF cell generates an output value by combining a scheme of amplifying a threshold voltage difference and a scheme of amplifying an oscillation frequency difference. In an oscillator that generates oscillation signals of different frequencies, the frequency difference of the oscillation signals is amplified by alternately supplying bias voltages of different magnitudes generated by utilizing the threshold voltage difference to a plurality of stages in the oscillator.

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