公开(公告)号：US07241902B2

公开(公告)日：2007-07-10

申请号：US10478396

申请日：2002-05-30

Applicant: Talia Miron ,  Aharon Rabinkov ,  David Mirelman ,  Meir Wilchek

Inventor： Talia Miron ,  Aharon Rabinkov ,  David Mirelman ,  Meir Wilchek

IPC: C07D207/08 ,  C07D205/04 ,  C07D211/16 ,  C07D223/04

CPC classification number: C07D207/16

Abstract: Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin.

Abstract translation: 作为大蒜素和ACE抑制化合物的反应产物的化合物可用于治疗高血压，升高的甘油三酸酯和升高的胰岛素。

公开(公告)号：US20070147445A1

公开(公告)日：2007-06-28

申请号：US10583125

申请日：2006-06-16

Applicant: Amiel Ishaaya ,  Nil Davidson ,  Asher Friesem ,  Liran Shimshi

Inventor： Amiel Ishaaya ,  Nil Davidson ,  Asher Friesem ,  Liran Shimshi

IPC: H01S3/13

CPC classification number: H01S3/07 ,  H01S3/0805 ,  H01S3/08054 ,  H01S3/08059 ,  H01S3/08063 ,  H01S3/08068 ,  H01S3/0811 ,  H01S3/0816 ,  H01S3/082 ,  H01S3/10 ,  H01S3/10092 ,  H01S3/1106 ,  H01S3/1307 ,  H01S3/2383 ,  H01S5/4012 ,  H01S5/4025 ,  H01S5/4062

Abstract: A resonator cavity (10A) and method and presented. The resonator cavity (10A) comprises at least one gain medium (16) and end reflectors (12, 14) which define together longitudinal modes of light in the cavity, and further comprises an intra-cavity beam coupler assembly (20). The beam coupler assembly (20) is configured to split light impinging thereon into a predetermined number of spatially separated light channels, and to cause phase locking and at least partial coherent combining of the light channels, having common longitudinal and transverse modes, in a double pass through the beam coupler assembly (20). The resonator cavity (10A) is configured and operable to produce at least one output combined light channel of a predetermined intensity profile.

Abstract translation: 一种谐振腔（10A）及其方法。 谐振器腔（10A）包括至少一个增益介质（16）和端部反射器（12,14），所述增益介质和端部反射器（12,14）将空腔中的纵向光模式一起限定，并且还包括腔内光束耦合器组件（20）。 光束耦合器组件（20）被配置成将入射到其上的光分解成预定数量的空间分离的光通道，并且使得具有共同的纵向和横向模式的光通道的相位锁定和至少部分相干组合在双 穿过光束耦合器组件（20）。 谐振器腔（10A）被配置和可操作以产生具有预定强度分布的至少一个输出组合光通道。

公开(公告)号：US07213230B2

公开(公告)日：2007-05-01

申请号：US10034433

申请日：2001-12-27

Applicant: David Harel ,  Rami Marelly

Inventor： David Harel ,  Rami Marelly

IPC: G06F9/44

CPC classification number: G06F8/10

Abstract: There is proposed a methodology for specifying the behavior of reactive systems, which is based on “Playing in” the system's possible scenarios. The use of this methodology is shown by building a practical “Play In Engine” tool based on the methodology. Users will be able to connect their Mock-Up GUI to the tool by “playing” their GUI and specifying the required system reactions in a simple and intuitive manner. As this is being done, the system will automatically generate behavior specifications in the language of Live Sequence Charts (LSCs), or any other suitable requirement language, such as various temporal logics or timing diagrams. On the basis of the system behavior specification, the user can play out scenarios through a play out engine.

Abstract translation: 提出了一种用于指定反应系统的行为的方法，其基于“播放”系统的可能情况。 通过构建基于该方法的实用“播放引擎”工具来显示该方法的使用。 用户可以通过“播放”其GUI并以简单直观的方式指定所需的系统反应，将他们的模拟GUI连接到该工具。 由于这样做，系统将自动生成活动序列图（LSC）的语言行为规范，或任何其他合适的需求语言，如各种时间逻辑或时序图。 在系统行为规范的基础上，用户可以通过播放引擎播放场景。

公开(公告)号：US07208138B2

公开(公告)日：2007-04-24

申请号：US11294625

申请日：2005-12-05

Applicant: Zishan Haroon ,  Mark W. Dewhirst ,  Charles S. Greenberg ,  Michal Neeman

Inventor： Zishan Haroon ,  Mark W. Dewhirst ,  Charles S. Greenberg ,  Michal Neeman

IPC: A61K49/00 ,  A61B5/055

CPC classification number: A61K49/14 ,  A61K49/085 ,  G01N33/4905

Abstract: Imaging agents for magnetic resonance imaging are disclosed. Methods of monitoring angiogenesis and the growth and remission of tumor tissue are also disclosed. Methods of monitoring blood clot formation and dissolution are additionally disclosed. Methods of monitoring wound healing are further disclosed. A kit for obtaining an image of a biological structure is further disclosed.

Abstract translation: 公开了用于磁共振成像的成像剂。 还公开了监测血管生成和肿瘤组织生长和缓解的方法。 还公开了监测血块形成和溶解的方法。 进一步公开了监测伤口愈合的方法。 还公开了一种用于获得生物结构图像的套件。

公开(公告)号：US20060251616A1

公开(公告)日：2006-11-09

申请号：US11484772

申请日：2006-07-12

Applicant: Orit Kollet ,  Tsvee Lapidot

Inventor： Orit Kollet ,  Tsvee Lapidot

IPC: A61K35/14 ,  A61K38/20 ,  A61K38/19

CPC classification number: C07K14/522 ,  A61K31/513 ,  A61K31/675 ,  A61K35/28 ,  A61K38/00 ,  A61K38/193 ,  A61K2300/00

Abstract: The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.

Abstract translation: 本发明涉及将造血干细胞（HSC）和/或祖细胞（HPC）移植到肝脏中。 更具体地，本发明涉及趋化因子，优选SDF-1用于增强HSC / HPC归巢到肝脏的用途。

公开(公告)号：US07118744B2

公开(公告)日：2006-10-10

申请号：US10032482

申请日：2002-01-02

Applicant: Irun R Cohen ,  Varda Rotter ,  Roland Wolkowicz ,  Pedro Ruiz ,  Neta Erez-Alon ,  Johannes Herkel

Inventor： Irun R Cohen ,  Varda Rotter ,  Roland Wolkowicz ,  Pedro Ruiz ,  Neta Erez-Alon ,  Johannes Herkel

IPC: A61K39/395 ,  C07P16/00 ,  C12P21/08

CPC classification number: C07K16/30 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K16/18 ,  C07K2317/565 ,  C07K2317/73

Abstract: The invention relates to the use of an immunogen selected from the group consisting of (i) an anti-p53 mAb; (ii) a fragment of an anti-p53 mAb; (iii) a peptide based on a CDR of the heavy or light chain of an anti-p53 mAb, which peptide is capable of eliciting antibodies to p53; and (iv) a DNA molecule coding for the variable (V) region of an anti-p53 mAb in a suitable gene delivery vehicle, for the preparation of a pharmaceutical composition useful for induction of anti-tumor immunity in mammals, for activating an enhanced immune response to a p53 molecule in mammals, and/or for induction of immune responses to mutated and wild-type forms of a p53 in mammals. The use of anti-p53 mAbs and novel peptides based on the CDR2 and CDR3 of the heavy chains and CDR3 of the light chains of different anti-p53 mAbs are disclosed.

公开(公告)号：US07109159B1

公开(公告)日：2006-09-19

申请号：US09403897

申请日：1998-04-26

Applicant: Dalit Barkan ,  Batya Cohen ,  Menachem Rubinstein

Inventor： Dalit Barkan ,  Batya Cohen ,  Menachem Rubinstein

IPC: A61K38/00

CPC classification number: A61K38/2264

Abstract: The use of leptin and leptin-related molecules in oncology is disclosed.

Abstract translation: 公开了瘦素和瘦蛋白相关分子在肿瘤学中的应用。

公开(公告)号：US07101675B2

公开(公告)日：2006-09-05

申请号：US10035408

申请日：2002-01-04

Applicant: David Wallach ,  Mark P Boldin ,  Eugene E Varfolomeev ,  Zeev Pancer ,  Igor Mett ,  Tanya M Goncharov

Inventor： David Wallach ,  Mark P Boldin ,  Eugene E Varfolomeev ,  Zeev Pancer ,  Igor Mett ,  Tanya M Goncharov

IPC: G01N33/53 ,  C12N9/64 ,  C12P21/06 ,  C12Q1/68

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/7155 ,  C07K16/18 ,  C07K16/2878

Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.

Abstract translation: 提供了由细胞内发生的调节性细胞事件的调节剂，其由含有“死亡域”基序的调节蛋白介导。 “死亡域”是调节蛋白的调节部分，并且调节剂能够与调节蛋白中包含的一个或多个“死亡域”基序相互作用并影响一种或多种调节蛋白的调节作用。 调节剂优选能够与p55-TNF-R，FAS / APO1-R，NGF-R，MORT-1，RIP，TRADD或锚蛋白内的'死亡域'基序相互作用。 还提供了一种制备调制剂的方法。 调节剂可用于通过含有“死亡域”的蛋白调节细胞介导的功能。

公开(公告)号：US07098304B1

公开(公告)日：2006-08-29

申请号：US09647457

申请日：1999-03-30

Applicant: Meir Shinitzky ,  Michael Deckmann

Inventor： Meir Shinitzky ,  Michael Deckmann

IPC: A61K38/04 ,  C07K5/00

CPC classification number: C12N9/88

Abstract: The invention concerns peptides which bind antibodies that are found in elevated levels in body fluids of schizophrenic patients and are found at a lower level or not found at all in body fluids of non-schizophrenic individuals. Using a computerized program, the antigenic epitope of the peptides of the invention is predicted as having a core of hydrophobic amino acids which is surrounded by positively charged amino acids. The peptides of the invention are useful in the diagnosis of schizophrenia in an individual.

Abstract translation: 本发明涉及结合在精神分裂症患者的体液中以升高水平发现的抗体的肽，并且发现在非精神分裂症个体的体液中的较低水平或根本没有发现。 使用计算机程序，预测本发明的肽的抗原表位具有被带正电荷的氨基酸包围的疏水性氨基酸的核心。 本发明的肽可用于个体中精神分裂症的诊断。

公开(公告)号：US07094882B2

公开(公告)日：2006-08-22

申请号：US10240411

申请日：2001-04-20

Applicant: Daniel Harari ,  Yosef Yarden

Inventor： Daniel Harari ,  Yosef Yarden

IPC: C07K16/00 ,  C07K16/18

CPC classification number: C07K16/22 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/28 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and methods of employing peptides or peptide analogs, oligonucleotides and oligonucleotide analogs, and/or polynucleotide sequences to up-regulate or down-regulate ErbB-4 receptor activity (signaling).

Abstract translation: 公开了一种新颖的ErbB-4配体，这里称为神经调节蛋白-4（NRG-4），以及编码NRG-4，衍生自多核苷酸序列的寡核苷酸和寡核苷酸类似物的多核苷酸序列，展示文库显示衍生自NRG- 4，识别NRG-4的抗体，衍生自NRG-4的肽或肽类似物，以及使用肽或肽类似物，寡核苷酸和寡核苷酸类似物的药物组合物和方法，和/或上调或下调ErbB- 4受体活性（信号传导）。