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11 条记录 (耗时 0.018 秒)

    Use of allicin as insect repellent and insecticide in agricultural crops
    2.
    发明申请
    Use of allicin as insect repellent and insecticide in agricultural crops 审中-公开
    在农作物中使用大蒜素作为驱虫剂和杀虫剂

    公开(公告)号：US20060110472A1

    公开(公告)日：2006-05-25

    申请号：US10512553

    申请日：2003-04-24

    申请人： Talia Miron ,  Aharon Rabinkov ,  Meir Wilchek ,  David Mirelman ,  Talila Volk

    发明人： Talia Miron ,  Aharon Rabinkov ,  Meir Wilchek ,  David Mirelman ,  Talila Volk

    IPC分类号： A01N65/00 ,  A01N31/00

    CPC分类号： A01N41/10 ,  A01N41/02

    摘要： The invention provides methods for: (a) protecting agricultural crops, particularly fruits and vegetables, against insects, by treating the crops with allicin prior to harvesting; (b) protecting fruits and vegetables from decay and extending the shelf life thereof by treating the fruits and vegetables with allicin after harvesting; and (c) repelling insects such as ants or insects that attack agricultural crops from an object or an area, which comprises treating the object or area with a repelling effective amount of allicin.

    摘要翻译： 本发明提供了以下方法：（a）通过在收获前用大蒜素处理作物，保护农作物，特别是水果和蔬菜免受昆虫的侵害; （b）保护水果和蔬菜免于腐烂，并通过在收获后用大蒜素处理水果和蔬菜延长其保质期; （c）排斥从物体或区域攻击农作物的昆虫如蚂蚁或昆虫，其中包括用排斥有效量的大蒜素处理该物体或区域。

    Mercaptopurine derivatives and uses thereof
    3.
    发明申请
    Mercaptopurine derivatives and uses thereof 审中-公开
    巯基嘌呤衍生物及其用途

    公开(公告)号：US20100069319A1

    公开(公告)日：2010-03-18

    申请号：US12529706

    申请日：2008-03-02

    申请人： Talia Miron ,  Aharon Rabinkov ,  David Mirelman ,  Meir Wilchek

    发明人： Talia Miron ,  Aharon Rabinkov ,  David Mirelman ,  Meir Wilchek

    IPC分类号： A61K31/70 ,  C07D473/00 ,  A61K31/52 ,  C07H19/167

    CPC分类号： C01F11/185 ,  C01F11/18

    摘要： The invention provides novel mercaptopurine derivatives, e.g., S-allylthio-6-mercaptopurine and S-allylthio-6-mercaptopurine 9-riboside, as well as pharmaceutical compositions thereof. These compounds are highly efficient anti-proliferative agents, thus can be useful for treatment of various diseases or disorders, in particular, proliferative, inflammatory, skin and immune diseases or disorders.

    摘要翻译： 本发明提供新的巯基嘌呤衍生物，例如S-烯丙硫基-6-巯基嘌呤和S-烯丙硫基-6-巯基嘌呤9-核苷，以及其药物组合物。 这些化合物是高效抗增殖剂，因此可用于治疗各种疾病或病症，特别是增殖性，炎性，皮肤和免疫疾病或病症。

    Garlic alliinase covalently bound to carrier for continuous production of allician
    6.
    发明授权
    Garlic alliinase covalently bound to carrier for continuous production of allician 失效
    大蒜蒜叶苷共价结合载体连续生产大蒜素

    公开(公告)号：US06689588B1

    公开(公告)日：2004-02-10

    申请号：US09171311

    申请日：2000-09-12

    申请人： David Mirelman ,  Meir Wilchek ,  Talia Miron ,  Aharon Rabinkov ,  Hephzibah Sivaraman

    发明人： David Mirelman ,  Meir Wilchek ,  Talia Miron ,  Aharon Rabinkov ,  Hephzibah Sivaraman

    IPC分类号： C12P1100

    CPC分类号： A61K31/21 ,  A23L29/06 ,  A23L33/105 ,  C12N9/88 ,  C12N11/00 ,  C12P11/00

    摘要： Immobilized garlic alliinase wherein the alliinase is chemically, physically or biologically immobilized, is useful in a method for continuous production of allicin. The method comprises adding a solution of alliin as substrate to a column containing the immobilized garlic alliinase and collecting pure allicin in the effluent. The pure allicin is intended for use as food additive or for the preparation of pharmaceutical compositions for the treatment of viral, bacterial, fungal and parasitic infections, high levels of cholesterol and blood lipids, high blood pressure and thrombosis.

    摘要翻译： 其中蒜氨酸酶化学，物理或生物固定的固定化蒜蒜素可用于连续生产大蒜素的方法。 该方法包括将含有蒜氨酸作为底物的溶液加入含有固定化蒜蒜素的柱中，并在流出物中收集纯大蒜素。 纯大蒜素旨在用作食品添加剂或用于制备用于治疗病毒，细菌，真菌和寄生虫感染，高水平胆固醇和血脂，高血压和血栓形成的药物组合物。

    COMPOSITIONS AND METHODS FOR TREATING ASPERGILLOSIS
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING ASPERGILLOSIS 审中-公开
    用于治疗ASPERGILLOSIS的组合物和方法

    公开(公告)号：US20120263719A1

    公开(公告)日：2012-10-18

    申请号：US13502794

    申请日：2010-10-21

    申请人： David Mirelman ,  Aharon Rabinkov ,  Elena Appel

    发明人： David Mirelman ,  Aharon Rabinkov ,  Elena Appel

    IPC分类号： A61K39/395 ,  C12N9/96 ,  C12N9/88 ,  C12N15/13 ,  A61P11/00 ,  C12N5/16 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61P31/10 ,  C07K16/14 ,  C12N15/63

    CPC分类号： C07K16/14 ,  A61K47/6815 ,  A61K47/6835 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C12N9/88

    摘要： The present invention provides monoclonal antibodies specific for members of the Aspergillus genus and uses thereof for increasing the survival rate of a subject infected with an Aspergillus species. The present invention also provides conjugates of alliinase with monoclonal antibodies specific for members of the Aspergillus genus that preserve the ability of the antibody to recognize the fungus as well as the activity of the enzyme to produce cytotoxic molecules of allicin from the substrate alliin. The invention further provides pharmaceutical compositions comprising the conjugates of the mAbs of the invention and alliinase and uses thereof in combination with the substrate alliin in the treatment of diseases cause by Aspergillus species, in particular invasive aspergillosis.

    摘要翻译： 本发明提供对曲霉属成员特异性的单克隆抗体及其用于增加感染曲霉属物种的受试者的存活率的用途。 本发明还提供了蒜氨酸酶与保护抗体识别真菌的能力以及从底物蒜氨酸产生大蒜素的细胞毒性分子的活性的曲霉属成员特异性的单克隆抗体的缀合物。 本发明进一步提供药物组合物，其包含本发明的mAb和蒜氨酸酶的缀合物及其与底物蒜氨酸联合用于治疗由曲霉属物种引起的疾病，特别是侵袭性曲霉病的疾病的用途。