-
公开(公告)号：US20190050524A1
公开(公告)日：2019-02-14
申请号：US16057040
申请日：2018-08-07
Inventor： Neal Woodbury
Abstract: Methods and applications for relating the structure of a molecule in a library to its function are described. Embodiments described herein relate structure to function by considering the covalent structure of the molecule, the components of that structure that are common to many molecules in the library, and the properties of those components as they relate to the function in question. Applications include, for example, enhancement and amplification of the diagnostic and prognostic signals provided by peptide arrays for use in analyzing the profile of antibodies in the blood produced in response to a disease, condition or treatment.
-
262.发明授权公开(公告)号：US10191068B2
公开(公告)日：2019-01-29
申请号：US15114356
申请日：2015-02-02
Inventor： Michael Sierks , Stephanie Williams , Lalitha Venkataraman
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
-
公开(公告)号：US20180375465A1
公开(公告)日：2018-12-27
申请号：US15780840
申请日：2016-12-05
Inventor： Rajapandian Ayyanar , Yinglai Xia , Jinia Roy
Abstract: Power converter circuitry includes a direct current (DC) input comprising a first DC input node and a second DC input node, an alternating current (AC) output comprising a first AC output node coupled to the first DC input node and a second AC output node, a first boost switch coupled between the second DC input node and a boost intermediate node, a second boost switch coupled between the boost intermediate node and a common node, a boost inductor coupled between the boost intermediate node and the first DC input node, a link capacitor coupled between the second DC input node and the common node, a first half-bridge switch coupled between the second DC input node and a half-bridge intermediate node, a second half-bridge switch coupled between the half-bridge intermediate node and the common node, and a half-bridge inductor coupled between the half-bridge intermediate node and the second AC output node.
-
264.发明授权公开(公告)号：US10157467B2
公开(公告)日：2018-12-18
申请号：US15231730
申请日：2016-08-08
Applicant: Arizona Board of Regents on Behalf of Arizona State University , Mayo Foundation For Medical Education And Research
Inventor： Esra Dincer , Michael Gotway , Jianming Liang
Abstract: A system and method for detecting central pulmonary embolisms in a subject's vasculature is provided. In some aspects, the method includes receiving, using the input, a set of images representing a vasculature of the subject's lungs, automatically analyzing the set of images to segment the main arteries associated with the subject's lungs and separate the main arteries from surrounding tissues. The method also includes automatically extracting central pulmonary embolism candidates from the set of images after segmenting and separating the main arteries, and automatically evaluating the central pulmonary embolism candidates in three-dimensional (3D) space by applying a series of rules. The method further includes automatically displaying a report indicating evaluated central pulmonary embolism candidates on a display.
-
公开(公告)号：US10153519B2
公开(公告)日：2018-12-11
申请号：US15104217
申请日：2014-12-24
Inventor： Hanqing Jiang , Hongyu Yu , Zeming Song
IPC: H01M2/02 , H01M4/66 , H01M4/70 , H01M10/04 , H01M10/0525 , H01M10/0583 , H01M10/052 , H01M10/058 , H01M2/18 , H01M4/02
Abstract: The invention is drawn to a lithium-ion battery containing a packaging material, an anode current collector, an anode electrode, a separator, a cathode electrode, and a cathode current collector, wherein those components are layered to form a planar battery. The planar battery is folded using rigid origami, such as Miura folding, to yield a folded, deformable lithium-ion battery.
-
Patent Agency Ranking
266.发明授权公开(公告)号：US10145846B2
公开(公告)日：2018-12-04
申请号：US15303960
申请日：2015-04-16
Inventor： Stuart Lindsay , Peiming Zhang , Pei Pang
IPC: G01N33/543 , B01L3/00 , G01N33/487
Abstract: A sensing device is provided that includes a tunnel junction created by forming a hole in a layered tunnel junction (for example). A chemically, well-defined surface may be formed by coupling affinity reagents to the electrodes, which, by these means, the surface may be configured to be selective for a particular analyte.
-
公开(公告)号：US20180334700A1
公开(公告)日：2018-11-22
申请号：US15757712
申请日：2016-10-07
Inventor： Jacob Messner , Clifford Anderson , Honor Glenn , Kristen Lee , Mark Richards , Laimonas Kelbauskas , Kimberly Bussey , Deirdre Meldrum
IPC: C12Q1/24 , G01N33/569
CPC classification number: C12Q1/24 , C12M1/00 , C12M23/12 , G01N33/56966
Abstract: Methods for seeding live cells onto spatially defined regions of a substrate including multiple features (e.g., microwells or other microenvironments) utilize a stencil embodied in a hole-defining sacrificial film. A sacrificial film devoid of holes may be applied over features of a substrate, and a hole generating mechanism (e.g., hot needle or laser) aligned with features may be used to define holes in the film. Alternatively, holes may be predefined in a sacrificial film to form a stencil, and the stencil may be assembled to the substrate with the holes registered with features thereof. Thereafter, cells are seeded through holes in the film. Seeded cells are subject to incubation, further processing, and/or performance of one or more assays, and the hole-defining sacrificial film (stencil) may be removed.
-
公开(公告)号：US10119960B2
公开(公告)日：2018-11-06
申请号：US15316710
申请日：2015-06-09
Inventor： Junseok Chae , Jennie Appel , Joseph Liao
IPC: G01N33/50 , G01N21/84 , G01N33/487 , G01N33/574
Abstract: Systems and methods for performing cancer screening assays are disclosed. The disclosed systems and methods use a thin film comprising cross-linked polysiloxane. At least a portion of a biological sample to be assayed is contacted with the thin film, along with a cell culture media. After a subsequent incubation period, the thin film is visualized to detect a wrinkle pattern (or lack thereof). The presence of one or more wrinkles and/or a higher degree of wrinkling in the thin film indicates the presence of cancer cells in the biological sample. The disclosed systems and methods can be incorporated into improved assays and kits for cancer screening.
-
公开(公告)号：US20180298086A1
公开(公告)日：2018-10-18
申请号：US15881392
申请日：2018-01-26
Inventor： Michael SIERKS , Huilai TIAN
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
-
公开(公告)号：US20180284114A1
公开(公告)日：2018-10-04
申请号：US15764143
申请日：2016-09-30
Inventor： Stephen Johnston
IPC: G01N33/543
Abstract: Provided herein are methods for processing biopolymeric arrays, where conditions suitable for forming complexes of immobilized biopolymers (e.g., peptides) and target molecules of a sample can be varied independently of conditions suitable for detecting such complexes using a secondary detection reagent.
-
-
-
-
-
-
-
-
-
Search Results
1764
records
(took 0.041 seconds)
