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271.发明公开公开(公告)号：US20230310430A1
公开(公告)日：2023-10-05
申请号：US18025252
申请日：2021-09-15
Inventor： In-Kyu LEE , Eun Jung CHOI , Chang Hyun JEON , Jae-Han JEON
IPC: A61K31/506 , A23L33/15 , A61P37/06
CPC classification number: A61K31/506 , A23L33/15 , A61P37/06
Abstract: The present invention relates to a pharmaceutical composition for preventing, treating, or ameliorating graft versus host disease (GVHD), comprising thiamine derivatives, in which the active ingredient of the pharmaceutical composition is fursultiamine, which can alleviate weight loss found in patients with GVHD, reduce the infiltration of liver and colon inflammatory cells, and effectively inhibit the production of allogeneic CD4+ IFNγ+ T cells, and thus can be effectively used for the prevention, treatment, or amelioration of GVHD.
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公开(公告)号：US20230309521A1
公开(公告)日：2023-10-05
申请号：US18041125
申请日：2021-06-24
Inventor： Dong Eog KIM
IPC: A01K67/027
CPC classification number: A01K67/027 , A01K2207/20 , A01K2207/30 , A01K2227/105 , A01K2267/0306
Abstract: The present invention relates to a method for producing animal models of cerebrovascular disease, comprising ligation of the common carotid artery (CCA) and administration of a nitric oxide (NO) inhibitor, animal models of cerebrovascular disease produced thereby, and a method for producing animals having small individual differences in susceptibility to the onset of cerebrovascular disease by using the same. The method for producing animal models of cerebrovascular disease according to the present invention can overcome the conventional problems of complexity and low yield. Particularly, the production method of the present invention can produce animal models of cerebrovascular disease with a high yield by a simple method. Moreover, the animal models produced by the production method may be used in studies to verify the effectiveness and safety of substances for the diagnosis, prevention or treatment of cerebrovascular disease or methods for treatment of cerebrovascular disease, and make it possible to study genes that cause differences in the level of cerebrovascular disease between the animal models. In addition, it is possible to provide offspring animals having uniform susceptibility to the onset of cerebrovascular disease by mating the animal models having similar susceptibilities to the onset of cerebrovascular disease according to the present invention.
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公开(公告)号：US11777041B2
公开(公告)日：2023-10-03
申请号：US17147969
申请日：2021-01-13
Inventor： Jun Hyung Kim , Sang Yoon Ji , Jang-Ung Park
IPC: H01M4/18 , H01L31/0224 , H01M4/04 , H01M4/36 , H01L31/18
CPC classification number: H01L31/022466 , H01L31/1884 , H01M4/0471 , H01M4/366
Abstract: Provided is a method of producing a patterned flexible electrode including: a nanowire formation step of applying a first dispersion containing a metal nanowire to a first sheet which is unwound from a wound state to form a nanowire network; a fiber formation step of electrospinning a second dispersion containing metal nanoparticles on the nanowire network to form a fiber-nanowire network in which a metallic fiber of the metal nanoparticles being agglomerated is incorporated into the nanowire network; a sintering step of photonically sintering the fiber-nanowire network to form a conductive network; and a patterning step of patterning the fiber-nanowire network before the sintering step or patterning the conductive network after the sintering step.
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公开(公告)号：US11773228B2
公开(公告)日：2023-10-03
申请号：US17725530
申请日：2022-04-20
Inventor： Chang Hyun Lee , Jin Pyo Hwang
IPC: C08J5/22 , B01J41/13 , B01D61/44 , B01D69/10 , B01D69/12 , B01D71/26 , B01D71/36 , B01D71/48 , B01D71/56 , B01D71/64 , B01D71/66 , B01J41/14 , B01J39/20
CPC classification number: C08J5/2293 , B01D61/44 , B01D69/10 , B01D69/12 , B01D71/26 , B01D71/36 , B01D71/48 , B01D71/56 , B01D71/64 , B01D71/66 , B01J41/13 , B01J41/14 , C08J5/2281 , B01J39/20 , C08J2327/18
Abstract: The present invention relates to a chemically modified anion exchange membrane and a method of preparing the same and, more particularly, an anion exchange membrane in which sulfonic acid groups in a perfluorinated sulfonic acid electrolyte membrane are substituted with anion conductive groups such as ammonium group, phosphonium group, imidazolium group, pyridinium group and sulfonium group, and a method of preparing an anion exchange membrane by chemically modifying sulfonic acid groups in a perfluorinated sulfonic acid electrolyte membrane.
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公开(公告)号：US20230307679A1
公开(公告)日：2023-09-28
申请号：US18036937
申请日：2021-08-17
Inventor： Chang Hyun LEE
IPC: H01M8/1039 , C08K3/22 , C08F214/26 , H01M8/1004 , H01M4/86
CPC classification number: H01M8/1039 , C08K3/22 , C08F214/262 , H01M8/1004 , H01M4/8668 , C08K2201/011 , C08K2201/00 , C08K2003/2213 , C08K2003/2227 , H01M2008/1095
Abstract: The present invention relates to: a method for preparing a nanocomposite of an ionomer and a metal oxide acting as a radical scavenger; and a fuel cell comprising a nanocomposite prepared thereby and, more specifically, to: a method for preparing a highly-dispersible radical scavenger metal oxide-ionomer nanocomposite which can be redispersed to the size of nanoparticles in an aqueous alcohol solution or an ionomer solution; and a membrane electrode assembly and fuel cell comprising a nanocomposite prepared thereby.
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Patent Agency Ranking
276.发明公开公开(公告)号：US20230307662A1
公开(公告)日：2023-09-28
申请号：US18189418
申请日：2023-03-24
Inventor： Dongil LEE , Yongsung JO
CPC classification number: H01M4/9008 , H01M12/06 , H01M4/8605 , H01M2004/8689
Abstract: The present invention provides an aqueous primary battery for carbon dioxide conversion containing a metal nanocluster catalyst, and a carbon dioxide conversion method capable of spontaneously converting carbon dioxide using the same even at high current density without the need for external power.
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公开(公告)号：US20230303638A1
公开(公告)日：2023-09-28
申请号：US18210179
申请日：2023-06-15
Inventor： Yoon Kyung PARK , Hee Kyoung KANG
IPC: C07K14/315 , A61P31/04 , A61K8/64 , A61Q19/00 , A23L33/18 , A23K20/147 , A61Q19/10
CPC classification number: C07K14/3156 , A61P31/04 , A61K8/64 , A61Q19/007 , A23L33/18 , A23K20/147 , A61Q19/10 , A23V2002/00 , A61K38/00
Abstract: In a method of killing or reducing a growth of methicillin-resistant Staphylococcus aureus (S. aureus), a composition including a peptide consisting of the amino acid sequence of SEQ ID NO:2 or 3 is administered to a subject in need thereof. The peptide can be usefully applied as an active ingredient for antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides and quasi-drugs.
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公开(公告)号：US20230301911A1
公开(公告)日：2023-09-28
申请号：US18122284
申请日：2023-03-16
Applicant: INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventor： Soo Jeong LIM , Eun A KIM , So Hee KIM , Hyeon Gyeom CHOI
IPC: A61K9/127 , A61P35/00 , A61K31/704
CPC classification number: A61K9/127 , A61K9/1271 , A61P35/00 , A61K9/1277 , A61K31/704
Abstract: A composition for delivering a drug includes a drug carrying liposome carrying a drug in a liposome, and an empty liposome which does not carry the drug and includes phospholipid having a head and two fatty acid chains, wherein both of the two fatty acid chains comprises omega-3 fatty acids or their derivatives.
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公开(公告)号：US11766444B2
公开(公告)日：2023-09-26
申请号：US16634460
申请日：2018-07-11
Inventor： Jae Sung Bae , Hee Kyung Jin , Ju Youn Lee , Min Hee Park
IPC: A61K31/661 , A61K47/69 , A61P25/28
CPC classification number: A61K31/661 , A61K47/6917 , A61P25/28
Abstract: The present invention relates to a novel use for HDL-ApoM-S1P (a high density lipoprotein in which apolipoprotein M is impregnated with sphingosine-1-phosphate), and more particularly, to using HDL-ApoM-S1P to prevent, improve, or treat degenerative brain disorders (in particular, Alzheimer's disease), cognitive disorders, learning disabilities, and memory disorders, and using HDL-ApoM-S1P to improve cognitive ability, learning ability, and memory.
The HDL-ApoM-S1P according to the present invention not only alleviates neuroinflammation but also significantly exhibits improvement effects of cognitive disorder, learning disability, and memory disorder with respect to individuals suffering from degenerative brain disorders (in particular, Alzheimer's disease), and exhibits an effect of greatly reducing amyloid beta and tau deposition. Moreover, increased HDL-ApoM-S1P in the body also has an excellent effect of improving the cognitive, learning, and memory abilities of non-disabled individuals.-
公开(公告)号：US20230295674A1
公开(公告)日：2023-09-21
申请号：US18146556
申请日：2022-12-27
Inventor： Sang Jun LEE , Hyun Ju Kim , Song Hee Jeong
CPC classification number: C12P17/10 , C12N15/1082 , C12N15/70 , C12N2800/101
Abstract: The present invention relates to a method for screening a target gene using a clustered regularly interspaced short palindromic repeats interference (CRISPRi) system and uses thereof. According to the present disclosure, it is expected that the method may be used in wide fields as a tool for genome-scale gene function profiling and studying organisms poorly developed in genetic technology, including pathogens or industrially useful strains or cell lines, and as a platform for electronic regulatory network engineering of genes.
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