Abstract:
Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula, (I).
Abstract:
A graft fixation device (1) comprising a sheath (2) having a body (9) that defines an inner longitudinal bore (8) and a member (3) for receipt within said bore (8), wherein said sheath (2) comprises at least one projection (15) moveably connected to said sheath body (9) and said at least one projection (15) is arranged so as to be displaceable radially outwardly of said sheath body (9) upon receipt of said member (3) within said bore (8).
Abstract:
This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
Abstract:
This invention relates to novel compositions comprising regioselectively substituted cellulose esters. One aspect of the invention relates to processes for preparing regioselectively substituted cellulose esters from cellulose dissolved in ionic liquids. Another aspect of the invention relates to the utility of regioselectively substituted cellulose esters in applications such as protective and compensation films for liquid crystalline displays.
Abstract:
A connector and a power transformer structure comprising the same are provided. The power transformer structure comprises a connector and an integrated transformer. The connector comprises a plurality of connection units, and the integrated transformer comprises a plurality of transformation units. The transformation units are sequentially stacked and electronically connected to the corresponding connection units in contact connection to reduce the current conduction consumption and contact resistance.
Abstract:
Word correlations are estimated using a content-based method, which uses visual features of image representations of the words. The image representations of the subject words may be generated by retrieving images from data sources (such as the Internet) using image search with the subject words as query words. One aspect of the techniques is based on calculating the visual distance or visual similarity between the sets of retrieved images corresponding to each query word. The other is based on calculating the visual consistence among the set of the retrieved images corresponding to a conjunctive query word. The combination of the content-based method and a text-based method may produce even better result.
Abstract:
The present disclosure provides a Non-Volatile Memory (NVM) cell and programming method thereof. The cell can denote at least two logic levels. The cell has a read-transistor with a floating gate, and Band-To-Band-Tunneling device (BTBT device) sharing the floating gate with the read-transistor. The BTBT device is configured as an injection device for injecting a first charge onto the floating gate when the BTBT device is biased with a first gate bias voltage such that the BTBT device is in accumulation, to set at least one of the logic levels. A first electrode is coupled to bias the BTBT device with a first bias voltage that is higher than the first threshold voltage. The first bias voltage is controlled such that the BTBT device is in accumulation during a write operation. The injected amount of charge on the floating gate is determined by the first bias voltage.
Abstract:
A selectively absorptive, mulitlayer wire-grid polarizer for polarizing incident light includes a stack of thin film layers disposed over a substrate, including a wire-grid array of elongated metal elements having a period less than half the wavelength of the light. One of the layers can include a thin film layer with a refractive index greater than a refractive index of the substrate. One of the thin film layers can include a dielectric array of non-metal elements. One of the layers includes a material that is optically absorptive to the incident light.
Abstract:
Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected from the group consisting of rectal, vaginal, urethral, sublingual and buccal, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein or peptide that comprises an epitope against which mucosal immunity is desired. The methods may be used to immunize and individual against a pathogen infection, hyperproliferative diseases or autoimmune diseases using nucleic acid molecules which encode proteins and peptides that share an epitope with a pathogen antigen or protein associated with cells involved in hyperproliferative diseases or autoimmune diseases, respectively,