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    TDP-43 knock-in mouse model of amyotrophic lateral sclerosis
    272.
    发明授权
    TDP-43 knock-in mouse model of amyotrophic lateral sclerosis 有权

    公开(公告)号：US11582957B2

    公开(公告)日：2023-02-21

    申请号：US16387430

    申请日：2019-04-17

    Applicant: Academia Sinica

    Inventor： Che-Kun James Shen ,  Shih-Ling Huang

    IPC: A01K67/027 ,  A61K49/00 ,  C07K14/47 ,  C12N5/0793 ,  G01N33/564 ,  G01N33/50

    Abstract: The invention relates to a genetically modified mouse comprising a heterozygous mutation of Tardbp (TDP-43) gene in that the Asn at amino acid 390 in TDP-43 is substituted with an amino acid that is different from Asn, wherein the genetically modified mouse exhibits Amyotrophic lateral sclerosis (ALS)-like phenotypes, TDP-43 proteinopathies and/or motor neuron degeneration. The invention also so relates to an isolated spinal cord motor neuron differentiated from an embryonic stem cell (ESC) that is obtained from an offspring of a genetically modified mouse according to the invention. Methods for identifying an agent alleviating and/or suppressing ALS-TDP pathogenesis are also disclosed.

    PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ß-CELL PATHOGENESIS AND TREATING DIABETES
    273.
    发明申请
    PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ß-CELL PATHOGENESIS AND TREATING DIABETES 有权

    公开(公告)号：US20230046445A1

    公开(公告)日：2023-02-16

    申请号：US17780482

    申请日：2020-11-15

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG ,  Keng-Chang TSAI

    IPC: A61K31/216 ,  A61K31/196 ,  A61P3/10

    Abstract: Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

    Microwell device and method of manufacturing the same
    275.
    发明授权
    Microwell device and method of manufacturing the same 有权

    公开(公告)号：US11492581B2

    公开(公告)日：2022-11-08

    申请号：US16838901

    申请日：2020-04-02

    Applicant: Academia Sinica

    Inventor： Keng-Hui Lin ,  Cheng-Kuang Huang

    IPC: C12M1/32 ,  C12M1/00 ,  B01L3/00 ,  C12N5/00

    Abstract: A microwell device and a method of manufacturing the same are provided. The microwell device includes a substrate and a plurality of microwells formed on the substrate. In addition, each of the microwells includes a cavity being recessed on the substrate and an opening, and the diameter of the opening is smaller than the largest inner diameter of the cavity. Furthermore, the microwells are curved.

    METHODS OF TREATING HYPERTRIGLYCERIDEMIA OR HYPERTRIGLYCERIDEMIA-RELATED DISEASES
    276.
    发明申请
    METHODS OF TREATING HYPERTRIGLYCERIDEMIA OR HYPERTRIGLYCERIDEMIA-RELATED DISEASES 有权

    公开(公告)号：US20220339245A1

    公开(公告)日：2022-10-27

    申请号：US17730195

    申请日：2022-04-27

    Applicant: Academia Sinica

    Inventor： Hsin-Fang YANG-YEN

    IPC: A61K38/17 ,  A61P3/06

    Abstract: The present invention is directed to methods of treating hypertriglyceridemia or hypertriglyceridemia-related diseases in a subject by using recombinant PRAP1 polypeptides. According to some embodiments of the present disclosure, the subject is a human, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 1 or 2. According to certain embodiments of the present disclosure, the subject is a mouse, in which the recombinant PRAP1 polypeptide comprises the amino acid sequence 100% identical to SEQ ID NO: 3 or 4.

    Method and Computer for Learning Correspondence Between Malware and Execution Trace of the Malware
    277.
    发明申请
    Method and Computer for Learning Correspondence Between Malware and Execution Trace of the Malware 有权

    公开(公告)号：US20220318387A1

    公开(公告)日：2022-10-06

    申请号：US17709923

    申请日：2022-03-31

    Applicant: ACADEMIA SINICA

    Inventor： Meng-Chang Chen ,  Yi-Ting Huang

    IPC: G06F21/56 ,  G06F21/55 ,  G06N5/02

    Abstract: A method for learning a correspondence between malware behaviors and an execution trace of the malware, comprising: receiving an execution trace which includes one or more sequences of application programming interface (API) calls, wherein each of the API calls is corresponding to one or more resources of a computer system; processing each sequence of the API calls in a process, respectively, for generating a binding group embedding for each of the resources corresponding to the API calls in each of the process; aggregating the binding group embeddings in each of the processes; producing a malware representation according to the aggregated binding group embeddings; and classifying the malware representation corresponding to techniques implemented by the malware.

    NANOCOMPOSITE PARTICLE AND USES THEREOF
    278.
    发明申请
    NANOCOMPOSITE PARTICLE AND USES THEREOF 有权

    公开(公告)号：US20220257524A1

    公开(公告)日：2022-08-18

    申请号：US17628559

    申请日：2020-09-01

    Applicant: Academia Sinica ,  National Yang Ming Chiao Tung University

    Inventor： Michael HSIAO ,  Ming-Hsien CHAN ,  Nelson G. CHEN ,  Ru-Shi LIU

    IPC: A61K9/51 ,  C09K11/02 ,  C09K11/77 ,  A61P35/00 ,  A61K41/00

    Abstract: Disclosed herein is a nanocomposite particle comprising a core-shell-shell nanoparticle, an encapsulated nanorod linked with the core-shell-shell nanoparticle, and a lipid layer encapsulating the core-shell-shell nanoparticle and the encapsulated nanorod. The core-shell nanoparticle comprises a phosphor core, an inner shell layer, an outer shell layer, and a cationic polymer. The encapsulated nanorod comprises a nanorod, and a mesoporous scaffold. According to embodiments of the present disclosure, the encapsulated nanorod is linked with the core-shell-shell nanoparticle via an electrostatic interaction between the cationic polymer and the mesoporous scaffold. Also disclosed are the uses of the nanocomposite in treating diseases, for example, cancers.

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