公开(公告)号：US20200185219A1

公开(公告)日：2020-06-11

申请号：US16349918

申请日：2017-11-29

Applicant: STC.UNM

Inventor： Tito Busani ,  Steven R.J. Brueck ,  Daniel Feezell ,  Mahmoud Behzadirad

IPC: H01L21/02 ,  G01Q60/38 ,  G01Q70/12

Abstract: Nanowires that may be utilized in microscopy, for example atomic force microscopy (AFM), as part of an AFM probe, as well as for other uses, are disclosed. The nanowires may be formed from a Group III nitride such as an epitaxial layer that may be or include gallium nitride, indium nitride, aluminum nitride, and an alloy of these materials. During use of the AFM probe to measure a topography of a test sample surface, the nanowire can activated and caused to lase and emit a light, thereby illuminating the surface with the light. In an implementation, the light can be collected by the AFM probe itself, for example through an optical fiber to which the nanowire is attached.

公开(公告)号：US10570381B2

公开(公告)日：2020-02-25

申请号：US16116117

申请日：2018-08-29

Applicant: Surojit Paul

Inventor： Surojit Paul

IPC: C07K14/47 ,  C07K19/00 ,  A61K38/17 ,  A61P25/00 ,  C12N9/16 ,  A61K38/46 ,  A61K38/00

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and/or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

公开(公告)号：US10561648B2

公开(公告)日：2020-02-18

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61K35/644 ,  A61K38/14 ,  C07K14/705 ,  A61K31/4741 ,  A61P31/04

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition —and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US10558269B2

公开(公告)日：2020-02-11

申请号：US16336065

申请日：2017-09-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Francesco Chinello ,  Daisuke Shibata ,  Domenico Prattichizzo

Inventor： Marco Santello ,  Francesco Chinello ,  Daisuke Shibata ,  Domenico Prattichizzo

IPC: G06F3/01 ,  F16H19/04

Abstract: A device for providing cutaneous sensations to a fingertip includes a lower base, an upper platform positioned over and mechanically connected to the lower base, and a shear plate positioned between the lower base and the upper platform and mechanically connected to the lower base. When a fingertip is positioned between the upper platform and the lower base, the upper platform is selectively vertically translatable relative to the lower base to provide a compressive force, and the shear plate is selectively laterally translatable relative to the lower base to provide a shear force. Accordingly, a wearable fingertip device having two degrees-of-freedom (DoF) to provide consecutive and/or concurrent compressive force and/or shear force to a fingertip is provided. The wearable fingertip device can be used in various scenarios; is portable, easily wearable, and easily manufacturable; and has low overall operating power requirements.

公开(公告)号：US10555519B2

公开(公告)日：2020-02-11

申请号：US15567106

申请日：2016-04-18

Applicant: Scott Matthews ,  Ravi Durvasula ,  Ivy Foo-Hurwitz

Inventor： Scott Matthews ,  Ravi Durvasula ,  Ivy Foo-Hurwitz

IPC: A01N25/28 ,  A01N65/00

Abstract: An larvicide comprising an essential oil encapsulated within a non-viable yeast cell. The larvicide is particularly effective against mosquito larvae, non-toxic to humans and other non-target species, inexpensive to make, and non-toxic during manufacture, transport, and storage.

公开(公告)号：US10548942B2

公开(公告)日：2020-02-04

申请号：US15962067

申请日：2018-04-25

Applicant: STC.UNM

Inventor： Jeff Wade Hill

IPC: A61K38/06 ,  C07K5/097 ,  A61K38/00 ,  C07K14/715 ,  A61K45/06

Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.

公开(公告)号：US10533991B2

公开(公告)日：2020-01-14

申请号：US15125896

申请日：2015-03-13

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L. Donabedian ,  Kiran Bhaskar

IPC: G01N33/52 ,  C08G61/02 ,  C12N1/20 ,  C12Q1/44 ,  C12Q1/46

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US20200002543A1

公开(公告)日：2020-01-02

申请号：US16565359

申请日：2019-09-09

Applicant: STC.UNM

Inventor： Richard Alan Kemp ,  Mahmoud Reda Taha

IPC: C09C1/48 ,  C08F120/44 ,  D01F1/10 ,  D01F9/22 ,  D01F9/127

Abstract: A method and precursor for making carbon fibers and the like comprising carbon black modified with at least one cyclic compound promoter. A source of the carbon black may be recycled materials such as recycled tires or recycled plastics. The carbon black is modified by attaching at least one cyclic compound promoter to the outer periphery of the carbon black.

公开(公告)号：US10511172B2

公开(公告)日：2019-12-17

申请号：US16186812

申请日：2018-11-12

Applicant: STC.UNM

Inventor： Andrea A. Mammoli ,  Yasser Yasaei

IPC: H02J3/38 ,  H02J7/00

Abstract: The present invention is an apparatus and method for using aggregated loads from a plurality of distributed energy resources to perform a function at a power distribution feeder. The invention includes a plurality of distributed energy resources, wherein at least one distributed energy resource includes a renewable energy resource, a communication network, a control device, a power distribution feeder coupled to the control device, and an energy storage system coupled to the power distribution feeder. The control device sends a signal to the plurality of distributed energy resources via the communication network. The signal is a request to switch a status of one or more of the distributed energy resources if one or more distributed energy resources is within a predetermined condition. Loads from the one or more of the distributed energy resources that switched status are aggregated to perform a function at the power distribution feeder.

公开(公告)号：US10464985B2

公开(公告)日：2019-11-05

申请号：US16039858

申请日：2018-07-19

Applicant: STC.UNM

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K51/00 ,  A61M36/14 ,  C07K14/68 ,  A61K51/08 ,  A61K45/06 ,  C07K7/54 ,  A61K38/00

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.