公开(公告)号：US10591491B1

公开(公告)日：2020-03-17

申请号：US16262168

申请日：2019-01-30

Applicant: STC.UNM

Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

IPC: G01N33/68

Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

公开(公告)号：US20200058500A1

公开(公告)日：2020-02-20

申请号：US16662236

申请日：2019-10-24

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R.J. Brueck

IPC: H01L21/02 ,  B81C1/00 ,  B82Y10/00 ,  H01L21/311 ,  H01L21/306 ,  H01L21/285 ,  H01L29/06 ,  H01L29/786 ,  H01L27/092 ,  H01L29/66 ,  H01L29/423 ,  H01L21/8238

Abstract: Provided is a method for growing a nanowire, including: providing a substrate with a base portion having a first surface and at least one support structure extending above or below the first surface; forming a dielectric coating on the at least one support structure; forming a photoresist coating over the substrate; forming a metal coating over at least a portion of the dielectric coating; removing a portion of the dielectric coating to expose a surface of the at least one support structure; removing a portion of the at least one support structure to form a nanowire growth surface; growing at least one nanowire on the nanowire growth surface of a corresponding one of the at least one support structure, wherein the nanowire comprises a root end attached to the growth surface and an opposing, free end extending from the root end; and elastically bending the at least one nanowire.

公开(公告)号：US10548994B1

公开(公告)日：2020-02-04

申请号：US14196343

申请日：2014-03-04

Applicant: STC.UNM

Inventor： Erin Damita Milligan ,  Jeffrey P. Norenberg

IPC: A61K31/4166 ,  A61K51/04 ,  A61K31/4174 ,  A61K38/18 ,  A61K38/20 ,  A61K38/34

Abstract: In one embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia by administering a therapeutically-effective amount of at least one LFA1 antagonist to the subject. In a preferred embodiment, the invention provides a method of treating a subject suffering from chronic neuropathic pain and/or allodynia, the method comprising administering intrathecally to the subject a therapeutically-effective amount of microparticles comprising PLGA-encapsulated pDNA-IL-10, optionally in combination with a therapeutically-effective amount of intrathecally-administered CpG oligodeoxynucleotide (CpG ODN) and/or at least one LFA1 antagonist.

公开(公告)号：US20200009143A1

公开(公告)日：2020-01-09

申请号：US16310615

申请日：2017-07-24

Applicant: STC.UNM

Inventor： Graham Timmins ,  Ke Jian Jim Liu ,  Xixi Zhou

IPC: A61K31/5025

Abstract: The present invention is directed to the discovery that pyrazinamide, a potent anti-tuberculosis agent acts through an entirely unexpected mechanism-through inhibition of the host enzyme poly ADP ribose polymerase (“PARP”). Thus, the present invention is directed to methods of treating: mycobacterial infections (Mycobacterium), especially M. tuberculosis using a PARP inhibitor, optionally in combination with at least one additional agent useful in the treatment of a mycobacterial infection, especially tuberculosis. Pharmaceutical compositions, especially including a pharmaceutical composition in oral or inhalation dosage form, comprising a inhibitor, optionally in combination with an additional anti-mycobacterial agent, especially an additional anti-tuberculosis agent represent additional embodiments of the present invention.

公开(公告)号：US10512651B2

公开(公告)日：2019-12-24

申请号：US15506421

申请日：2015-08-21

Applicant: STC.UNM

Inventor： Ellen Janine Beswick

IPC: A61K31/554 ,  A61K38/00 ,  A61K31/553 ,  A61K31/167 ,  A61K45/06 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/551 ,  A61P35/00 ,  A61K31/165

Abstract: The present invention relates to the discovery that MK2 is highly expressed in cancer tissue and the inhibition of MK2 using an MK2 inhibitor represents a viable approach to the treatment of cancer, including drug resistant cancers, metastatic cancers and recurrent cancers. MK2 inhibitors as described herein may be used alone or in combination with an at least one additional anti-cancer agent for the treatment of cancer.

公开(公告)号：US20190351013A1

公开(公告)日：2019-11-21

申请号：US16482009

申请日：2018-01-31

Applicant: STC.UNM

Inventor： Zurab Surviladze ,  Michelle A. Ozbun ,  Andrew Cowan

IPC: A61K38/16 ,  A61K38/08 ,  A61K38/10 ,  A61K9/00 ,  A61K47/36

Abstract: An arginine-rich polypeptide composition includes an arginine-rich polypeptide and a pharmaceutically acceptable carrier. Generally, the arginine-rich polypeptide has at least nine arginine residues that represent at least 10% of the amino acid residues in the polypeptide. The arginine-rich polypeptide may be used in a method of inhibiting a human papilloma virus (HPV) from binding to a cell, a method of inhibiting intracellular processing of human papilloma virus (HPV) by a cell, or a method of treating a subject having, or at risk of having, a human papilloma virus (HPV) infection.

公开(公告)号：US10483415B2

公开(公告)日：2019-11-19

申请号：US15904296

申请日：2018-02-23

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Brittany R. Hoard ,  Sang M. Han ,  Swapnadip Ghosh

IPC: G02B1/00 ,  H01L31/0236 ,  H01L31/18 ,  H01L31/0747 ,  H01L31/20 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25

Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

公开(公告)号：US10483105B2

公开(公告)日：2019-11-19

申请号：US15573772

申请日：2016-05-13

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/02 ,  B81C1/00 ,  B82Y10/00 ,  H01L21/8238 ,  H01L29/423 ,  H01L29/66 ,  H01L27/092 ,  H01L29/786 ,  H01L29/06 ,  H01L21/285 ,  H01L21/306 ,  H01L21/311 ,  B82Y40/00

Abstract: Provided is a method for growing a nanowire, including: providing a substrate with a base portion having a first surface and at least one support structure extending above or below the first surface; forming a dielectric coating on the at least one support structure; forming a photoresist coating over the substrate; forming a metal coating over at least a portion of the dielectric coating; removing a portion of the dielectric coating to expose a surface of the at least one support structure; removing a portion of the at least one support structure to form a nanowire growth surface; growing at least one nanowire on the nanowire growth surface of a corresponding one of the at least one support structure, wherein the nanowire comprises a root end attached to the growth surface and an opposing, free end extending from the root end; and elastically bending the at least one nanowire.

公开(公告)号：US10474927B2

公开(公告)日：2019-11-12

申请号：US15757261

申请日：2016-09-02

Applicant: STC.UNM ,  Yin Yang

Inventor： Yin Yang

IPC: G06K9/62 ,  G06T13/20 ,  G06T17/20 ,  G06F17/16

Abstract: Technologies are disclosed for precomputation of reduced deformable models. In such precomputation, a Krylov subspace iteration may be used to construct a series of inertia modes for an input mesh. The inertia modes may be condensed into a mode matrix. A set of cubature points may be sampled from the input mesh, and cubature weights of the set of cubature points may be calculated for each of the inertia modes in the mode matrix. A training dataset may be generated by iteratively adding training samples to the training dataset until a training error metric converges, wherein each training sample is generated from an inertia mode in the mode matrix and corresponding cubature weights. The reduced deformable model may be generated, including inertia modes in the training dataset and corresponding cubature weights.

公开(公告)号：US20190282716A1

公开(公告)日：2019-09-19

申请号：US16267477

申请日：2019-02-05

Applicant: STC.UNM

Inventor： YUBIN MIAO ,  HAIXUN GUO

IPC: A61K51/08 ,  G01N33/60 ,  G01N33/574 ,  C07K14/685 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.