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公开(公告)号：US20100022973A1
公开(公告)日：2010-01-28
申请号：US11916033
申请日：2006-06-01
IPC分类号： A61M1/00
CPC分类号： A61B10/007 , A61B10/0038 , A61B10/0045 , A61B10/0051 , B01L3/505 , G01N2001/028
摘要： [Problems] An object of the present invention is to develop a sheet-shaped base material or a container having a structure which is designed in such a manner that snot or phlegm is collected as a biological excretory substance and said biological excretory substance is able to be easily applied to a test in medical therapy and also to develop a system where the biological excretory substance is collected using the same.[Solving Means] A biological excretory substance is collected using a bag-shaped container constituted from a sheet-shaped base material comprising a soft porous material only, a soft nonporous material only or a compounded material of a soft nonporous material and a soft porous material and then it is retained in the container.
摘要翻译： 发明内容本发明的目的是开发一种片状基材或容器，其结构设计成使得嗅或痰被收集为生物排泄物质，并且所述生物排泄物能够 容易地应用于药物治疗试验，并开发利用其进行生物排泄物收集的系统。 [解决方案]使用由仅包含软多孔材料的片状基材，仅软质无孔材料或软质无孔材料的复合材料和软质多孔材料构成的袋形容器收集生物排泄物质 然后将其保留在容器中。
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公开(公告)号：US07235369B2
公开(公告)日：2007-06-26
申请号：US10608025
申请日：2003-06-30
申请人： Hirokazu Ohbayashi , Yuriko Kitano
发明人： Hirokazu Ohbayashi , Yuriko Kitano
IPC分类号： G01N33/53
CPC分类号： G01N33/535 , Y10S435/96 , Y10S435/964
摘要： A complex of enzyme, protein and carrier comprising two or more molecules of an enzyme conjugated through an amino group or other group to a carrier such as polylysine, and a protein (for example, antibody) with a specific binding potency to other substance(s) (for example, antigen) conjugated to at least one of said two or more molecules of the enzyme. This complex enables accurate assay of a trace amounts of a substance at a high sensitivity.
摘要翻译： 包含通过氨基或其它基团共轭的两个或更多分子的酶，载体如聚赖氨酸的蛋白质和载体的复合物，以及与其它物质具有特异性结合力的蛋白质（例如抗体） ）（例如，抗原），其与酶的所述两个或更多个分子中的至少一个缀合。 该复合物能够以高灵敏度精确测定痕量的物质。
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公开(公告)号：US11156602B2
公开(公告)日：2021-10-26
申请号：US16399050
申请日：2019-04-30
发明人： Hirokazu Ohbayashi , Kayoko Fujita
IPC分类号： G01N33/58 , G01N33/53 , C12Q1/68 , G01N33/532 , G01N33/535 , G01N33/536 , C12Q1/28 , C12Q1/42
摘要： The present invention relates to a combination product for detecting a target marker simply and with high sensitivity. More specifically, the present invention relates to a combination product for detecting a target marker in a biological sample in combination with a target marker binding molecule which is capable of binding specifically to the target marker in the biological sample, the combination comprising, at least: (a) a first binding agent comprising a first binding molecule which is capable of directly or indirectly binding specifically to the target marker binding molecule, and a labeling substance; (b) a linker molecule which is capable of binding specifically to the first binding agent; and (c) a second binding agent which is capable of binding specifically to the linker molecule, and comprises a second binding molecule and a labeling substance.
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公开(公告)号：US10684200B2
公开(公告)日：2020-06-16
申请号：US16139569
申请日：2018-09-24
摘要： An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied.
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公开(公告)号：US20200149999A1
公开(公告)日：2020-05-14
申请号：US16609074
申请日：2018-04-27
发明人： Shinobu MASUDA , Ryohei SUZUKI , Yuriko KITANO
摘要： The present invention is to provide a tissue slice selection method and an embedded block-preparing cassette which are capable of suppressing occurrence of errors in inspection results. The present invention makes it possible to suppress the occurrence of errors in inspection results by including: an embedded block-preparing process of preparing an embedded block by embedding both a biological tissue fragment and a standard substance in the same embedding agent; an embedded tissue slice preparing step of slicing the embedded block to prepare a sheet-like embedded tissue slice having a tissue slice and standard substance slices appearing on a surface thereof; and a tissue slice selecting step of selecting the tissue slice to be inspected, based on a light signal from the standard substance slice.
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公开(公告)号：US20190324020A1
公开(公告)日：2019-10-24
申请号：US16399050
申请日：2019-04-30
发明人： Hirokazu OHBAYASHI , Kayoko FUJITA
IPC分类号： G01N33/53 , G01N33/58 , G01N33/535 , G01N33/532 , G01N33/536 , C12Q1/68
摘要： The present invention relates to a combination product for detecting a target marker simply and with high sensitivity. More specifically, the present invention relates to a combination product for detecting a target marker in a biological sample in combination with a target marker binding molecule which is capable of binding specifically to the target marker in the biological sample, the combination comprising, at least: (a) a first binding agent comprising a first binding molecule which is capable of directly or indirectly binding specifically to the target marker binding molecule, and a labeling substance; (b) a linker molecule which is capable of binding specifically to the first binding agent; and (c) a second binding agent which is capable of binding specifically to the linker molecule, and comprises a second binding molecule and a labeling substance.
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公开(公告)号：US20190025164A1
公开(公告)日：2019-01-24
申请号：US16139569
申请日：2018-09-24
摘要： An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied.
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公开(公告)号：US20170292899A1
公开(公告)日：2017-10-12
申请号：US15511481
申请日：2015-09-18
CPC分类号： G01N1/312 , G01N1/28 , G01N1/30 , G01N33/48 , G01N35/00029 , G01N35/00722 , G01N35/0095 , G01N2035/00138 , G01N2035/00356
摘要： Provided are an automatic tissue staining device and an automatic tissue staining method capable of advancing treatments according to precise treatment times without a hitch. The automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples on the one or more glass slides situated in the first region, suspends a start of a treatment for the samples on the one or more glass slides situated in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples on the one or more glass slides situated in the first region when the horizontal direction movement unit is not occupied.
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公开(公告)号：US20160003718A1
公开(公告)日：2016-01-07
申请号：US14759612
申请日：2014-01-08
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , B01L3/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/0621 , B01L2200/0684 , B01L2300/047 , B01L2300/048 , B01L2300/0822 , B01L2300/0877 , B01L2400/0406 , G01N1/30 , G01N35/1002
摘要： A liquid filling aid that is placed on a plate-shaped member and defines a reaction chamber to be filled with a liquid, the aid includes a main body, a storage section that is formed in the main body and stores the liquid, a reaction section that is a recess formed at a bottom of the main body, a communication aperture for fluid communication between the storage section and the reaction section, and an air vent for communication between the reaction section and outside air, wherein the reaction section and an upper surface of the plate-shaped member define the reaction chamber and a liquid filling method including a step of placing the liquid filling aid on the plate-shaped member, and a step of discharging the liquid in an amount equal to or larger than the volume of the reaction chamber for supply to the storage section.
摘要翻译： 一种液体填充辅助剂，其被放置在板状构件上并限定要填充液体的反应室，所述助剂包括主体，形成在主体中并存储液体的储存部分，反应部分 是形成在主体的底部的凹部，用于存储部和反应部之间的流体连通的连通孔，以及用于反应部和外部空气之间连通的排气口，其中反应部和上表面 所述板状构件限定所述反应室，以及液体填充方法，包括将所述液体填充辅助剂放置在所述板状构件上的步骤，以及以等于或大于所述板状构件的体积的量排出所述液体的步骤 反应室供给储存部分。
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30.发明授权Proanthocyanidin of cashew apple, composition containing proanthocyanidin, and application thereof 有权腰果苹果花青素，含有原花色素的组合物及其应用公开(公告)号：US08575368B2
公开(公告)日：2013-11-05
申请号：US13142238
申请日：2009-06-25
申请人： Kenichi Nagamine
发明人： Kenichi Nagamine
IPC分类号： C07D311/76 , A61K31/353
CPC分类号： C12N9/99 , A23L33/105 , A23L33/195 , A23V2002/00 , A61K31/353 , A61K36/22 , C07D311/62 , A23V2250/21166 , A23V2250/21 , A23V2250/5086
摘要： This invention provides useful applications of cashew apple. This invention also provides a naturally occurring active ingredient having useful activities, such as alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes. The invention also provides a composition containing cashew apple-derived proanthocyanidin having excellent alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes, which is prepared by allowing a plant fiber-degrading enzyme (e.g., pectinase) to react with a cashew apple and concentrating the resultant with the use of an ultrafiltration membrane. Further, the invention provides a proanthocyanidin compound having a novel structure.
摘要翻译： 本发明提供腰果苹果的有用应用。 本发明还提供具有有用活性的天然存在的活性成分，例如α-淀粉酶抑制活性，脂肪酶抑制活性和对痤疮丙酸杆菌的抗菌活性。 本发明还提供一种含有腰果苹果衍生的原花青素的组合物，其具有优异的α-淀粉酶抑制活性，脂肪酶抑制活性和对痤疮丙酸杆菌的抗菌活性，其通过使植物纤维降解酶（例如果胶酶）与 腰果苹果，并使用超滤膜浓缩所得物。 此外，本发明提供具有新颖结构的原花青素化合物。
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