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公开(公告)号：US09279737B2
公开(公告)日：2016-03-08
申请号：US13974932
申请日：2013-08-23
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
IPC: G01M3/32
CPC classification number: G01M3/3218 , G01M3/3263
Abstract: A portable flexible container integrity test device for conducting integrity testing of flexible containers is disclosed. The test device is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The test device includes a programmable logic controller (PLC), a pressure transducer in electronic communication with the PLC, a power source configured to provide electrical power to the PLC, a blower in electronic communication with the PLC, a gas delivery pathway in selective fluid communication with the blower, and a human/machine interface in electronic communication with the PLC. The device is portable and configured to fluidly connect to a flexible container via the gas delivery pathway.
Abstract translation: 公开了用于进行柔性容器的完整性测试的便携式柔性容器完整性测试装置。 测试装置特别适用于以保持容器的无菌性质的方式测试无菌柔性膜袋，并且通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。 测试装置包括可编程逻辑控制器（PLC），与PLC电子通信的压力传感器，被配置为向PLC提供电力的电源，与PLC电子通信的鼓风机，选择性流体中的气体输送路径 与鼓风机的通信，以及与PLC电子通信的人机界面。 该装置是便携式的并且构造成经由气体输送路径流体地连接到柔性容器。
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公开(公告)号：US20160001242A1
公开(公告)日：2016-01-07
申请号：US14321120
申请日：2014-07-01
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf PAVLIK
IPC: B01F13/02
CPC classification number: B01F13/0238 , B01F3/04248 , B01F11/0082 , B01F15/0085 , C12M23/14 , C12M29/06
Abstract: A plunge-mixing bag arrangement includes a flexible mixing bag defining a mixing region, and a shaft extending from outside of the flexible mixing bag into the mixing region, the shaft comprising a sparger within the mixing region. The sparger comprises an interior channel and ports extending from the interior channel. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports. A plunge-mixing system includes a mechanism for raising and lowering the shaft.
Abstract translation: 插入式混合袋装置包括限定混合区域的柔性混合袋和从柔性混合袋的外部延伸到混合区域中的轴，该轴在混合区域内包括喷雾器。 喷射器包括内部通道和从内部通道延伸的端口。 轴能够在袋内轴向运动，以破裂通过端口从内部通道释放的气泡。 插入式混合系统包括用于升高和降低轴的机构。
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公开(公告)号：US09079690B1
公开(公告)日：2015-07-14
申请号：US14315936
申请日：2014-06-26
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
CPC classification number: A61J1/16 , A01N1/0263 , A01N1/0268 , A61J1/10 , A61J1/1475 , B65D31/06 , F25D31/00
Abstract: A freezer bag, a storage system, and a method of freezing are provided. The freezer bag includes a pliable housing including at least one panel and a seam, the at least one panel and the seam defining a cavity within the pliable housing, a port extending from the pliable housing, and a tufting coupling opposing sides of the pliable housing, the tufting dividing the cavity into a plurality of regions.
Abstract translation: 提供冷冻袋，储存系统和冷冻方法。 冷冻袋包括柔韧的壳体，其包括至少一个面板和接缝，所述至少一个面板和接缝限定柔性外壳内的空腔，从柔性外壳延伸的端口，以及与柔性外壳 ，簇绒将空腔分成多个区域。
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24.发明授权公开(公告)号：US08979357B1
公开(公告)日：2015-03-17
申请号：US14338607
申请日：2014-07-23
Applicant: Advanced Scientifics, Inc.
Inventor： Rudolf Pavlik
IPC: B01F13/00
CPC classification number: B01F13/00 , B01F7/162 , B01F7/1695 , B01F13/0032 , B01F15/00837 , B01F15/0085 , B01F2215/0032 , B01F2215/0073 , B65D77/06
Abstract: A mixing system and mixing arrangement are provided. The mixing system includes a rigid container including an integral support plate; a mixing assembly supported on the integral support plate, the mixing assembly including a pliable enclosure containing a fluid and a mixing device, a portion of the mixing device extending from the pliable enclosure and adapted to be detachably coupled to a drive mechanism; and a first plate detachably secured to the rigid container. The pliable enclosure is in compression between the first plate and the integral support plate. The mixing arrangement includes a docking station including a drive cradle and a drive mechanism, a rigid container removably positioned within the drive cradle, a mixing assembly positioned within the rigid container, and a first plate configured to be detachably secured to the rigid container.
Abstract translation: 提供混合系统和混合装置。 该混合系统包括一个包含整体支撑板的刚性容器; 支撑在整体支撑板上的混合组件，所述混合组件包括容纳流体和混合装置的柔性外壳，所述混合装置的一部分从柔性外壳延伸并适于可拆卸地联接到驱动机构; 以及可拆卸地固定到刚性容器的第一板。 柔性外壳在第一板和整体支撑板之间处于压缩状态。 混合装置包括对接站，该对接站包括驱动支架和驱动机构，可拆卸地定位在驱动支架内的刚性容器，位于刚性容器内的混合组件以及被配置为可拆卸地固定到刚性容器的第一板。
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公开(公告)号：US20140083169A1
公开(公告)日：2014-03-27
申请号：US13974771
申请日：2013-08-23
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf PAVLIK
IPC: G01M3/32
CPC classification number: G01M3/3218 , G01M3/3263
Abstract: A portable test device and related method are disclosed for conducting integrity testing of flexible containers. The test is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The decay in pressure is measured over a predetermined period of time; if pressure loss does not exceed a predetermined threshold the integrity of the bag is confirmed and it can be filled without further manipulation of the container that may result in introducing flaws.
Abstract translation: 公开了用于进行柔性容器的完整性测试的便携式测试装置和相关方法。 该测试对于以保持容器的无菌性质的方式测试无菌柔性膜袋特别有用，并通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。 在预定的时间段内测量压力衰减; 如果压力损失不超过预定阈值，则确认袋的完整性，并且可以在不进一步操纵可能导致缺陷的容器的情况下填充袋。
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Patent Agency Ranking
公开(公告)号：US20220054996A1
公开(公告)日：2022-02-24
申请号：US17521201
申请日：2021-11-08
Applicant: Advanced Scientifics, Inc.
Inventor： Rudolf Pavlik
Abstract: A mixing system includes a container having an encircling sidewall bounding a chamber and extending between an upper end and an opposing lower end; a support plate disposed within the chamber and secured to the encircling sidewall; an inner wall secured to the support plate and projecting within the chamber toward the upper end, an open space being formed between the inner wall and the encircling sidewall; and a first aperture extending through the encircling sidewall so as to communicate with the open space. A mixing assembly is positioned within the container and is supported on the support plate, the mixing assembly including a pliable enclosure and a mixing device.
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公开(公告)号：US10463571B2
公开(公告)日：2019-11-05
申请号：US16162125
申请日：2018-10-16
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
Abstract: A bag assembly includes a first panel secured to a second panel by a seam so that a cavity is formed between the first panel and the second panel, the seam encircling the cavity. A first seal couples together the first panel and the second panel at a location spaced apart from the seam so that the cavity encircles the first seal. In one embodiment, the first seal can be circular. A first port communicates with the cavity.
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公开(公告)号：US10350562B2
公开(公告)日：2019-07-16
申请号：US15652487
申请日：2017-07-18
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
Abstract: A mixing system includes a tank assembly and a container positioned within the tank assembly, the container bounding a compartment. A mixer is disposed within the compartment of the container. A shaft has a first end secured to the mixer and an opposing second end disposed outside of the container. An actuation mechanism is coupled with the second end of the shaft outside of the container and reciprocally moves the shaft and the mixer a stroke length, the stroke length being adjusted based on a pre-programmed protocol or signals from a sensor.
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公开(公告)号：US10111809B2
公开(公告)日：2018-10-30
申请号：US14875442
申请日：2015-10-05
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
Abstract: A method for forming an aseptic connection includes inserting an end of a sealed fill connector into a receptacle of an aseptic connector assembly; moving a pivot portion of the aseptic connector assembly relative to a body portion of the aseptic connector assembly so as to sever a portion of the fill connector, the pivot portion being at least partially disposed within the body portion; and advancing a conduit portion of the aseptic connector assembly into the fill connector so as to form an aseptic connection therebetween, the conduit portion being at least partially disposed within the pivot portion or the body portion of the aseptic connector assembly after advancing.
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公开(公告)号：US09737863B2
公开(公告)日：2017-08-22
申请号：US14794641
申请日：2015-07-08
Applicant: ADVANCED SCIENTIFICS, INC.
Inventor： Rudolf Pavlik
CPC classification number: B01F15/0085 , B01F3/1221 , B01F11/0048 , B01F11/0082 , B01F15/00129 , B01F15/00155 , B01F15/00207 , B01F15/00253 , B01F15/00259 , B01F15/00402 , B01F15/00467 , B01F15/00538 , B01F2215/0073 , C12M23/14
Abstract: A mixing system and mixing method are provided. The mixing system includes a tank assembly, a container positioned within the tank assembly, a mixer disposed within a compartment of the container, a linear motor, and a shaft having a first end secured to the mixer and an opposing second end secured to the linear motor. The linear motor provides a variable stroke length for the shaft. The mixing method includes providing a tank assembly having a linear motor, positioning a mixing assembly including a mixing bag in the tank assembly, combining two or more components in a compartment of the mixing bag, attaching a mixing shaft extending from a mixer disposed within the mixing bag to the linear motor, and raising and lowering the mixing shaft to mix the two or more components. A stroke length of the mixing shaft during the raising and lowering is varied.
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