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21.发明申请MODIFIED POLYNUCLEOTIDES ENCODING COPPER METABOLISM (MURR1) DOMAIN CONTAINING 1 有权编码铜的代谢（MURR1）修饰的多核苷酸1公开(公告)号：US20140105965A1
公开(公告)日：2014-04-17
申请号：US14104568
申请日：2013-12-12
IPC分类号： C12N15/85
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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22.发明申请Compositions And Methods for Inhibiting Expression Of A Gene From the Ebola Virus 有权用于抑制来自埃博拉病毒的基因表达的组合物和方法公开(公告)号：US20130225654A1
公开(公告)日：2013-08-29
申请号：US13627508
申请日：2012-09-26
申请人： Sina Bavari , Kelly Lyn Warfield , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Antonin de Fougerolles
发明人： Sina Bavari , Kelly Lyn Warfield , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Antonin de Fougerolles
IPC分类号： C07H21/02
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及用于抑制埃博拉病毒基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US20130184326A1
公开(公告)日：2013-07-18
申请号：US13619657
申请日：2012-09-14
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
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公开(公告)号：US08344131B2
公开(公告)日：2013-01-01
申请号：US13355930
申请日：2012-01-23
申请人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
发明人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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25.发明授权公开(公告)号：US08334273B2
公开(公告)日：2012-12-18
申请号：US12970673
申请日：2010-12-16
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
摘要翻译： 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US20120087925A1
公开(公告)日：2012-04-12
申请号：US13296778
申请日：2011-11-15
IPC分类号： A61K39/395 , A61P19/02
CPC分类号： C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
摘要翻译： 公开了治疗炎症性疾病的方法，特别是治疗关节炎。 该方法包括施用能够结合VLA-1表位的功能阻断抗体。
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27.发明申请公开(公告)号：US20120016009A1
公开(公告)日：2012-01-19
申请号：US13245730
申请日：2011-09-26
IPC分类号： A61K31/713 , A61P9/10 , A61P3/06
CPC分类号： C12N15/87 , A61K48/00 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2320/35 , C12N2310/3521 , C12N2310/3533
摘要： This invention relates to optimized methods for treating diseases caused by PCSK9 gene expression.
摘要翻译： 本发明涉及治疗由PCSK9基因表达引起的疾病的优化方法。
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公开(公告)号：US20110263681A1
公开(公告)日：2011-10-27
申请号：US13090580
申请日：2011-04-20
申请人： Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
发明人： Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
摘要翻译： 本公开涉及可用于使用治疗有效量治疗β-ENAC相关疾病如囊性纤维化，1型假性醛固酮增多症（1例（PHA1），跛行综合征，高血压，碱中毒，低钾血症和肥胖相关性高血压）的方法中的RNAi剂 的RNAi试剂到β-ENaC。
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29.发明授权Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide 有权使用寡核苷酸刺激免疫应答并抑制基因表达的方法公开(公告)号：US08003619B2
公开(公告)日：2011-08-23
申请号：US11298850
申请日：2005-12-09
IPC分类号： C12N15/11
CPC分类号： C12N15/117 , A61K39/00 , A61K39/39 , A61K2039/53 , C12N15/1138 , C12N2310/14 , C12N2310/17 , C12N2310/3231
摘要： This invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.
摘要翻译： 本发明提供了通过刺激IFN产生来调节免疫应答的寡核苷酸试剂以及使用这些试剂用于哺乳动物的治疗处理的方法。
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30.发明申请Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus 有权抑制埃博拉病毒基因表达的组合物和方法公开(公告)号：US20110060031A1
公开(公告)日：2011-03-10
申请号：US12789414
申请日：2010-05-27
申请人： Sina Bavari , Kelly Lyn Warfield , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Antonin de Fougerolles
发明人： Sina Bavari , Kelly Lyn Warfield , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Antonin de Fougerolles
IPC分类号： A61K31/713 , C07H21/02 , C12N5/07 , C12N5/00 , A61P31/14
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及用于抑制埃博拉病毒基因表达的双链核糖核酸（dsRNA）。
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