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公开(公告)号：US11609239B2
公开(公告)日：2023-03-21
申请号：US17094178
申请日：2020-11-10
Applicant: BD KIESTRA B.V.
Inventor： Jetze Botma , Martijn Kleefstra , Tino Walter Van der Zee
Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.
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公开(公告)号：US20220404381A1
公开(公告)日：2022-12-22
申请号：US17836130
申请日：2022-06-09
Applicant: BD KIESTRA B.V.
Inventor： Michael John Wilsher , Simon Jowett , Roy Norman Gladwin , Mark William Horobin , Kenneth Charles Smith , Duncan Stevenson , Timothy Roy Hansen , Johannes Wijnandus Thiecke
Abstract: An improved system and method for the selection and dispensing of reagents onto a target testing medium in an automated laboratory environment. The system utilizes multiple carousels rotatably-mounted upon a central turntable. The position of the central turntable, as well as the rotation of each carousel is controlled by a microprocessor-based control system. Multiple dispensers, each capable of storing and dispensing a particular reagent, are mounted about the circumference of each carousel. This configuration provides much higher reagent density than previously available. The testing medium is positioned at one or more loading stations. The control system directs the central turntable to a position from which a selected one of the carousels can be rotated so as to position a selected dispenser above the testing medium. The selected dispenser is then actuated to release a predetermined reagent onto the testing medium. The system can be configured so that multiple reagents can be dispensed, each from an associated dispenser, onto a single or multiple testing mediums. Each of these actuated dispensers being positioned over the targeted testing medium(s) positioned at one or more loading stations.
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公开(公告)号：US20220325225A1
公开(公告)日：2022-10-13
申请号：US17621008
申请日：2020-06-26
Applicant: BD KIESTRA B.V.
Inventor： Raphael Rodolphe Marcelpoil , Martijn Kleefstra , Franciscus Feijen , Jean-Marc Volle , Mariska Okkema-Van Der Lei , Gerard Mulder , Eelke Johannes Veeninga
Abstract: An apparatus that configures a culture plate for precisely assigning coordinates to a selected colony by assigning fiducials to the culture plate using simple mechanical techniques. The fiducials correspond to the plate center and the center of a barcode label applied to the side of the culture plate by the apparatus. The apparatus then deploys mechanisms to apply coordinates to colonies identified by the user relative to the fiducials. One such mechanism is a webcam pointed at the culture plate that allows a technician to mark the colonies on a display using a computer mouse or equivalent cursor. Another mechanism deploys a laser pointer directed at the colony wherein the apparatus assigns coordinates to the location of the colony onto which the laser pointer is directed. In a third mechanism, the user views the surface of the culture plate through a viewfinder and manually registers coordinates when the view finder cross hairs are over a target colony. The selected colonies are assigned precise coordinates with reference to the two fiducials. Software is provided such that pixels in the image of the culture plate correspond to the coordinates of the culture dish relative to the fiducials.
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公开(公告)号：US20220290089A1
公开(公告)日：2022-09-15
申请号：US17632597
申请日：2020-08-05
Applicant: BD KIESTRA B.V.
Inventor： Brent Ronald Pohl , Franciscus Hermannus Feijen , Robert Edward Armstrong , Ammon David Lentz
Abstract: A multi-port disposable device that can both vent a sealed culture vessel and draw a sample therefrom into a collection vessel. The multi-port disposable device has a first port configured to receive the top portion of a culture vessel and attach thereto. The multi-port disposable device has a second port configured to receive a sample collection vessel. The multi-port disposable device has first and second needles. The first needle has a cannula configured to penetrate a septum or cap of the culture vessel. Optionally, the cannula terminates in a layer of foam that carries a microbial agent such that any vapor that is transmitted from the culture vessel through the cannula when venting the sealed culture vessel is absorbed by the foam. Optionally, the ports of the disposable device are configured as sleeves. The sleeve of the first port receives a portion of the culture vessel and the sleeve of the second port receives the collection vessel. The second needle has a cannula that penetrates both the septum or cap of the culture vessel and the septum or cap of the collection vessel, when the culture vessel and the collection vessel are brought into the device, thereby providing for fluid communication between the culture vessel and the collection vessel. The second cannula provides the flow pathway for delivering sample from the culture vessel to the collection vessel.
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公开(公告)号：US20220098542A1
公开(公告)日：2022-03-31
申请号：US17468838
申请日：2021-09-08
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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Patent Agency Ranking
26.发明授权公开(公告)号：US10935490B2
公开(公告)日：2021-03-02
申请号：US15513448
申请日：2015-09-29
Applicant: BD Kiestra B.V.
Inventor： Brian Reuben Langhoff , William Alan Fox , Kerry Lynn Smith
Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.
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公开(公告)号：US10921336B2
公开(公告)日：2021-02-16
申请号：US15575665
申请日：2016-05-27
Applicant: BD Kiestra B.V.
Inventor： Timothy Roy Hansen , Rick Holtz , Martijn Kleefstra , Raphael R. Marcelpoil , Rick Pierpont , Brent Ronald Pohl , Alyssa Shedlosky , Scott Shindledecker , Edward Skevington , Kerry Lynn Smith , Timothy M. Wiles
Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample. The apparatus and system optionally provides for downstream processing of samples prepared for antibiotic susceptibility testing (AST). Such apparatus includes further processing after inoculation of an AST panel for the AST test. Such further processing includes capping and transferring inoculated panels to AST instrument.
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公开(公告)号：US10654666B2
公开(公告)日：2020-05-19
申请号：US15572719
申请日：2016-05-13
Applicant: BD KIESTRA B.V.
Inventor： Michael Justin Lizzi , Lukas Blaauw , Timothy Roy Hansen , Freerk H. Van Der Werff , Jurjen Sinnema , Jordan Brown , James Glen Burmaster , Rui Goncalves , Milenko Lukic , Nino Orucevic , Martin John Juritsch
Abstract: A separating system (1) comprises a housing (60) sized to receive a stack of articles having at least one first article (12) stacked on top of a second article (10). The system (1) also includes a lifter (20) movable into a contact position adjacent a surface (13) on the at least one first article (12). The lifter (20) is adapted to apply a lifting force to the surface (13) to lift at least a portion of the first article (12) above the contact position. An extractor (40) moves the second article (10) away from the stack of articles after the at least one first article (12) has been lifted above the contact position by the lifter (20). The housing (60) prevents the at least one first article (12) from moving with the second article (10) when the second article (10) is moved by the extractor (40) and guides the stack of articles downward after the second article (10) is moved away.
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公开(公告)号：US10200625B2
公开(公告)日：2019-02-05
申请号：US15115715
申请日：2015-01-30
Applicant: BD Kiestra B.V.
Inventor： Raphael R. Marcelpoil , Cedrick Orny , Didier Morel
Abstract: An image capture system and method for imaging biological samples disposed in culture media supported by a plate. The system has a calibration module, an image acquisition module and an image presentation module. When the system receives a culture plate for imaging, default values for the culture plate and media are used to begin image acquisition at a given time. The captured image is then used to create a pixel by pixel map of the image. The system inspects the pixel-by-pixel map for saturated pixels and for signal to noise ratio and acquires a new image if the number of saturated pixels is at or above a predetermined threshold or the signal to noise ratio for the pixel is below a predetermined threshold. From this inspection a new value of photon flux and/or exposure time is determined and a new image is captured using the new value and the steps are repeated. Upon a determination that a predetermined threshold signal to noise ratio has been obtained for the non-saturated pixels, or when the predetermined upper threshold for the time interval for image acquisition is elapsed the system provides a final image for the given time.
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公开(公告)号：US20180340205A1
公开(公告)日：2018-11-29
申请号：US16052233
申请日：2018-08-01
Applicant: BD KIESTRA B.V.
Inventor： Trienko Marten Van Der Kaap , Martijn Kleefstra , lngela Marie Sofie Edlund Tjernberg , Jetze Botma
Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of:a) contacting at least one ferromagnetic particle with a solid carrier, followed or preceded by providing the particle with at least part of said sample, andb) applying a magnetic field gradient to allow for magnetically controlled motion of said particle on said surface, such that at least part of the sample is streaked onto the solid carrier. Also provided is an apparatus for carrying out such method in an (semi-)automated fashion.
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