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公开(公告)号：US20180072982A1
公开(公告)日：2018-03-15
申请号：US15560048
申请日：2016-03-30
Applicant: BD KIESTRA B.V. , BD KIESTRA B.V.
Inventor： Martijn Xander BERNTSEN , Jurjen SINNEMA , Martijn Kleefstra
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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公开(公告)号：US12228483B2
公开(公告)日：2025-02-18
申请号：US17235171
申请日：2021-04-20
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Martijn Kleefstra , Roger Petri , Tino Walter Van Der Zee
Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
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公开(公告)号：US11655445B2
公开(公告)日：2023-05-23
申请号：US17468838
申请日：2021-09-08
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
IPC: C12M1/00 , C12M1/36 , C12N1/02 , C12Q1/24 , G01N35/00 , G01N35/10 , C12M1/26 , C12M1/30 , G01N1/02
CPC classification number: C12M47/02 , C12M33/02 , C12M33/04 , C12M41/48 , C12N1/02 , C12Q1/24 , G01N35/0099 , G01N35/10 , G01N35/1011 , G01N2001/028
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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公开(公告)号：US20210199546A1
公开(公告)日：2021-07-01
申请号：US17255299
申请日：2019-06-24
Applicant: BD KIESTRA B.V.
Inventor： Timothy Roy Hansen , Martijn Kleefstra , Michael Bois , Timothy M. Wiles , Charles Chak Cheung Yu
Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
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公开(公告)号：US10557113B2
公开(公告)日：2020-02-11
申请号：US15560048
申请日：2016-03-30
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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Patent Agency Ranking
公开(公告)号：US20170336426A1
公开(公告)日：2017-11-23
申请号：US15663540
申请日：2017-07-28
Applicant: BD KIESTRA B.V
Inventor： Jetze Botma , Martijn Kleefstra , Tino Walter Van der Zee
CPC classification number: G01N35/00029 , C12M23/10 , C12M33/04 , C12M41/48 , C12Q3/00 , G01N35/10 , G01N2001/045 , G01N2035/1032 , H01J49/164
Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.
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7.发明授权Disc dispensing device, tubular container for use in such a disc dispensing device and method of dispensing discs 有权盘分配装置，用于这种盘分配装置的管状容器和分配盘的方法公开(公告)号：US09557343B2
公开(公告)日：2017-01-31
申请号：US14671226
申请日：2015-03-27
Applicant: BD Kiestra B.V.
Inventor： Jetze Botma , Martijn Kleefstra , Trienko Marten Van Der Kaap , Martijn Xander Berntsen , Jan Bart Van Der Vijver
CPC classification number: G01N35/1002 , C12M41/48 , C12M99/00 , C12M99/02
Abstract: Disc dispensing device for dispensing discs impregnated with antibiotics onto a culture dish. The device comprises a stationary support on which a magazine is removably mounted. The magazine holds a plurality of tubular containers each containing a stack of discs to be dispensed. A moving means moves one disc from a bottom end of a tubular container to a pick-up position. From the pick-up position a transfer means picks up said one disc and transfers it to the culture dish where it is dispensed. The removable culture dish is supported by a moveable carriage which is mounted on the stationary support. The carriage is moveable relative to the magazine from a starting position to an operating position and vice versa. Control means control the operation of the device. The plurality of tubular containers is rotatable around a magazine centre under control of the control means.
Abstract translation: 用于将浸渍有抗生素的盘分配到培养皿上的盘分配装置。 该装置包括一个固定支架，一个仓可移动地安装在该固定支架上。 杂志保持多个管状容器，每个管状容器包含要分配的一叠盘。 移动装置将一个盘从管状容器的底端移动到拾取位置。 从拾取位置，转印装置拾取所述一个盘并将其转移到其分配的培养皿中。 可移动培养皿由安装在固定支架上的可移动托架支撑。 托架可相对于料仓从起始位置移动到操作位置，反之亦然。 控制装置控制设备的运行。 多个管状容器在控制装置的控制下可围绕盒子中心旋转。
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公开(公告)号：US12258553B2
公开(公告)日：2025-03-25
申请号：US18133561
申请日：2023-04-12
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
IPC: C12N1/02 , C12M1/00 , C12M1/26 , C12M1/30 , C12M1/36 , C12Q1/24 , G01N35/00 , G01N35/10 , G01N1/02
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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公开(公告)号：US11609239B2
公开(公告)日：2023-03-21
申请号：US17094178
申请日：2020-11-10
Applicant: BD KIESTRA B.V.
Inventor： Jetze Botma , Martijn Kleefstra , Tino Walter Van der Zee
Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.
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公开(公告)号：US20220325225A1
公开(公告)日：2022-10-13
申请号：US17621008
申请日：2020-06-26
Applicant: BD KIESTRA B.V.
Inventor： Raphael Rodolphe Marcelpoil , Martijn Kleefstra , Franciscus Feijen , Jean-Marc Volle , Mariska Okkema-Van Der Lei , Gerard Mulder , Eelke Johannes Veeninga
Abstract: An apparatus that configures a culture plate for precisely assigning coordinates to a selected colony by assigning fiducials to the culture plate using simple mechanical techniques. The fiducials correspond to the plate center and the center of a barcode label applied to the side of the culture plate by the apparatus. The apparatus then deploys mechanisms to apply coordinates to colonies identified by the user relative to the fiducials. One such mechanism is a webcam pointed at the culture plate that allows a technician to mark the colonies on a display using a computer mouse or equivalent cursor. Another mechanism deploys a laser pointer directed at the colony wherein the apparatus assigns coordinates to the location of the colony onto which the laser pointer is directed. In a third mechanism, the user views the surface of the culture plate through a viewfinder and manually registers coordinates when the view finder cross hairs are over a target colony. The selected colonies are assigned precise coordinates with reference to the two fiducials. Software is provided such that pixels in the image of the culture plate correspond to the coordinates of the culture dish relative to the fiducials.
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