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    SYSTEM AND METHOD FOR ENHANCE THE USER EXPERIENCE OF APPLICATIONS FOR PROXIMITY-BASED PEER-TO-PEER MOBILE COMPUTING
    23.
    发明申请
    SYSTEM AND METHOD FOR ENHANCE THE USER EXPERIENCE OF APPLICATIONS FOR PROXIMITY-BASED PEER-TO-PEER MOBILE COMPUTING 审中-公开
    系统和方法，用于提高用户对基于对等的对等移动计算的应用体验

    公开(公告)号：US20170064753A1

    公开(公告)日：2017-03-02

    申请号：US15119602

    申请日：2014-03-26

    Applicant: Haijun ZHAO ,  Brian SPENCER ,  QUALCOMM Incorporated

    Inventor： Haijun ZHAO ,  Brian SPENCER

    IPC: H04W76/02 ,  H04W8/24 ,  H04W8/18 ,  H04W4/00

    Abstract: The disclosure is related to searching for a second device to provide a service that a first device is attempting to establish. The first device sends a search profile and a capabilities profile to the second device using near field communication (NFC), the search profile including criteria describing the service the first device is attempting to establish, the capabilities profile including connection capabilities of the first device, receives a score from the second device, the score indicating a closeness of a match between the search profile and the capabilities profile and one or more services and capabilities of the second device, and determines whether to connect with the second device to establish the service based on the received score.

    Abstract translation: 本公开涉及搜索第二设备以提供第一设备尝试建立的服务。 第一设备使用近场通信（NFC）向第二设备发送搜索简档和能力简档，搜索简档包括描述第一设备尝试建立的服务的标准，包括第一设备的连接能力的能力简档， 从所述第二设备接收分数，所述得分表示所述搜索简档和所述能力简档之间的匹配的接近度以及所述第二设备的一个或多个服务和能力，并且确定是否与所述第二设备连接以建立所述服务 在收到的分数。

    COMPOSITIONS AND METHODS FOR TARGETING A POLYPEPTIDE TO THE CENTRAL NERVOUS SYSTEM
    25.
    发明申请
    COMPOSITIONS AND METHODS FOR TARGETING A POLYPEPTIDE TO THE CENTRAL NERVOUS SYSTEM 审中-公开
    将多肽分配给中央神经系统的组合物和方法

    公开(公告)号：US20100015117A1

    公开(公告)日：2010-01-21

    申请号：US12499641

    申请日：2009-07-08

    Applicant: Inder M. Verma ,  Brian Spencer

    Inventor： Inder M. Verma ,  Brian Spencer

    IPC: A61K38/43 ,  A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  A61K31/7088 ,  A61P25/00

    CPC classification number: C12N15/62 ,  A61K38/02 ,  A61K38/28 ,  A61K38/30 ,  A61K47/64 ,  C07K2319/74

    Abstract: The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, α2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells.

    Abstract translation: 本发明提供了具有BBB受体结合结构域和有效载荷多肽结构域的嵌合CNS靶向多肽。 嵌合CNS靶向多肽可以具有由ApoB，ApoE，抑肽酶，脂蛋白脂肪酶，PAI-1，假单胞菌外毒素A，转铁蛋白，α2-巨球蛋白，胰岛素样生长因子，胰岛素的受体结合结构域组成的BBB受体结合结构域 ，或其功能片段。 还提供了编码嵌合CNS靶向多肽的核酸。 还提供了将多肽递送至个体的CNS的方法。 该方法包括向个体施用有效量的嵌合CNS靶向多肽，所述嵌合CNS靶向多肽包含BBB受体结合结构域和有效载荷多肽结构域。 该方法还可以将多肽递送至CNS细胞的溶酶体。

    Compositions and methods for targeting a polypeptide to the central nervous system
    26.
    发明申请
    Compositions and methods for targeting a polypeptide to the central nervous system 审中-公开
    将多肽靶向中枢神经系统的组合物和方法

    公开(公告)号：US20060198833A1

    公开(公告)日：2006-09-07

    申请号：US11401604

    申请日：2006-04-10

    Applicant: Inder Verma ,  Brian Spencer

    Inventor： Inder Verma ,  Brian Spencer

    IPC: A61K38/47

    CPC classification number: C12N15/62 ,  A61K38/02 ,  A61K38/28 ,  A61K38/30 ,  A61K47/64 ,  C07K2319/74

    Abstract: The invention provides a chimeric CNS targeting polypeptide having a BBB-receptor binding domain and a payload polypeptide domain. The chimeric CNS targeting polypeptide can have a BBB-receptor binding domain consisting of a receptor binding domain from ApoB, ApoE, aprotinin, lipoprotein lipase, PAI-1, pseudomonas exotoxin A, transferrin, α2-macroglobulin, insulin-like growth factor, insulin, or a functional fragment thereof. Nucleic acids encoding a chimeric CNS targeting polypeptide are also provided. Further provided is a method of delivering a polypeptide to the CNS of an individual. The method consists of administering to the individual an effective amount of a chimeric CNS targeting polypeptide, said chimeric CNS targeting polypeptide comprising a BBB-receptor binding domain and a payload polypeptide domain. The method also can deliver a polypeptide to the lysosomes of CNS cells.

    Abstract translation: 本发明提供了具有BBB受体结合结构域和有效载荷多肽结构域的嵌合CNS靶向多肽。 嵌合CNS靶向多肽可以具有由ApoB，ApoE，抑肽酶，脂蛋白脂肪酶，PAI-1，假单胞菌外毒素A，转铁蛋白，α2-巨球蛋白，胰岛素样生长因子，胰岛素的受体结合结构域组成的BBB受体结合结构域 ，或其功能片段。 还提供了编码嵌合CNS靶向多肽的核酸。 还提供了将多肽递送至个体的CNS的方法。 该方法包括向个体施用有效量的嵌合CNS靶向多肽，所述嵌合CNS靶向多肽包含BBB受体结合结构域和有效载荷多肽结构域。 该方法还可以将多肽递送至CNS细胞的溶酶体。

    System for generating alarms based on alarm patterns
    29.
    发明授权
    System for generating alarms based on alarm patterns 有权
    基于报警模式生成报警的系统

    公开(公告)号：US09095316B2

    公开(公告)日：2015-08-04

    申请号：US13450942

    申请日：2012-04-19

    Applicant: James P. Welch ,  Brian Spencer Long

    Inventor： James P. Welch ,  Brian Spencer Long

    IPC: G08B23/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/1455 ,  G08B21/04 ,  A61B5/0245

    CPC classification number: A61B5/746 ,  A61B5/0205 ,  A61B5/02455 ,  A61B5/14551 ,  G08B21/0453 ,  G16H40/63 ,  G16H40/67

    Abstract: An alarm system can include one or more processors. Such processors can receive physiological parameter data associated with a patient. The one or more processors can also select an alarm pattern based at least in part on an indicator of an attribute of the patient. The alarm pattern can include a plurality of different thresholds and corresponding periods of time. Further, the one or more processors can generate an alarm when a value associated with the physiological parameter data satisfies at least one threshold of the plurality of thresholds for the period of time corresponding to the at least one threshold.

    Abstract translation: 报警系统可以包括一个或多个处理器。 这样的处理器可以接收与患者相关联的生理参数数据。 所述一个或多个处理器还可以至少部分地基于患者的属性的指示符来选择警报模式。 警报模式可以包括多个不同的阈值和相应的时间段。 此外，当与生理参数数据相关联的值满足对应于至少一个阈值的时间段中的多个阈值的至少一个阈值时，一个或多个处理器可以产生警报。

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