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61 条记录 (耗时 0.093 秒)

    Anti-mpl ligand (thromobpoietin) antibodies
    21.
    发明授权
    Anti-mpl ligand (thromobpoietin) antibodies 失效
    抗-mpl配体（血小板生成素）抗体

    公开(公告)号：US08399250B1

    公开(公告)日：2013-03-19

    申请号：US08430035

    申请日：1995-04-27

    申请人： Dan L. Eaton ,  Frederic J. De Sauvage

    发明人： Dan L. Eaton ,  Frederic J. De Sauvage

    IPC分类号： C12N5/16 ,  C07K16/24

    CPC分类号： C07K14/524

    摘要： Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are used for treatment of thrombocytopenia.

    摘要翻译： 公开了分离的mpl配体，编码mpl配体的分离的DNA和制备mpl配体的重组方法。 显示这些mpl配体影响血液细胞，特别是巨核细胞祖细胞的复制，分化或成熟。 因此，这些化合物用于治疗血小板减少症。

    Method of Diagnosing the presence of a tumor in a mammal by assessing CDO expression level
    22.
    发明申请
    Method of Diagnosing the presence of a tumor in a mammal by assessing CDO expression level 有权
    通过评估CDO表达水平来诊断哺乳动物肿瘤存在的方法

    公开(公告)号：US20120128585A1

    公开(公告)日：2012-05-24

    申请号：US13286695

    申请日：2011-11-01

    申请人： Frederic J. de Sauvage ,  Hua Tian

    发明人： Frederic J. de Sauvage ,  Hua Tian

    IPC分类号： A61K49/00 ,  A61P35/00 ,  C12Q1/68 ,  A61K51/04 ,  A61K39/395 ,  G01N33/53

    CPC分类号： C12N5/069 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/392 ,  C12N2501/41 ,  G01N33/57484

    摘要： The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

    摘要翻译： 本发明提供了使用BOC / CDO刺猬蛋白拮抗剂抑制刺猬蛋白信号传导的方法，以及治疗和诊断与刺猬蛋白信号传导或过度表达刺猬的疾病，包括癌症，细胞增殖性疾病和血管发生，神经障碍，以及 作为受刺猬信号传导影响的其他条件，如毛发生长，神经干细胞分化，软骨形成和成骨，肺表面活性物质生成，肺细胞中层状体的形成。

    Gene disruptions, compositions and methods relating thereto
    27.
    发明授权
    Gene disruptions, compositions and methods relating thereto 失效
    基因破坏，组合物和方法

    公开(公告)号：US07858843B2

    公开(公告)日：2010-12-28

    申请号：US11814361

    申请日：2006-05-18

    申请人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

    发明人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

    IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

    摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

    摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

    Method for using BOC/CDO to modulate hedgehog signaling
    28.
    发明授权
    Method for using BOC/CDO to modulate hedgehog signaling 失效
    使用BOC / CDO调节刺猬信号的方法

    公开(公告)号：US07625759B2

    公开(公告)日：2009-12-01

    申请号：US11625717

    申请日：2007-01-22

    申请人： Frederic J. de Sauvage ,  Hua Tian

    发明人： Frederic J. de Sauvage ,  Hua Tian

    IPC分类号： H01L21/20 ,  A61K38/00

    CPC分类号： C12N5/069 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/392 ,  C12N2501/41 ,  G01N33/57484

    摘要： The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.

    摘要翻译： 本发明提供了使用BOC / CDO刺猬蛋白拮抗剂抑制刺猬蛋白信号传导的方法，以及治疗和诊断与刺猬蛋白信号传导或过度表达刺猬的疾病，包括癌症，细胞增殖性疾病和血管发生，神经障碍，以及 作为受刺猬信号传导影响的其他条件，如毛发生长，神经干细胞分化，软骨形成和成骨，肺表面活性物质生成，肺细胞中层状体的形成。