公开(公告)号：US20090313707A1

公开(公告)日：2009-12-17

申请号：US11814361

申请日：2006-05-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330。 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080311107A1

公开(公告)日：2008-12-18

申请号：US11814136

申请日：2007-02-09

申请人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel A. Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Trac Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

发明人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel A. Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Trac Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

IPC分类号： A61K39/395 ,  A61K51/00 ,  C12N5/06 ,  A61P25/00 ,  A61P27/12 ,  C07K16/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20120005766A1

公开(公告)日：2012-01-05

申请号：US13205917

申请日：2011-08-09

申请人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

发明人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

IPC分类号： A61K49/00 ,  C12Q1/68 ,  C40B30/04 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 循环异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US07858843B2

公开(公告)日：2010-12-28

申请号：US11814361

申请日：2006-05-18

申请人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

发明人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080160034A1

公开(公告)日：2008-07-03

申请号：US11572702

申请日：2005-08-23

申请人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

发明人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  C12N5/06 ,  A61P27/02 ,  C07K16/18 ,  G01N33/567

CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO196，PRO217，PRO231，PRO236，PRO245，PRO246，PRO258，PRO287，PRO328，PRO344，PRO357，PRO526，PRO724，PRO731，PRO732，PRO1003，PRO1104，PRO1151，PRO1244，PRO1298中的中断 ，PRO1313，PRO1570，PRO1886，PRO1891，PRO4409，PRO5725，PRO5994，PRO6097，PRO7425，PRO10102，PRO10282，PRO61709或PRO779基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20110097330A1

公开(公告)日：2011-04-28

申请号：US11722967

申请日：2006-02-27

申请人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

发明人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

IPC分类号： A61K49/00 ,  C07K16/18 ,  A61K39/00 ,  A61P25/00 ,  A61P9/00 ,  A61P37/00 ,  A61P27/02 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P27/06 ,  A61P27/12 ,  A61P9/10 ,  A61P19/02 ,  A61P19/10 ,  C12Q1/68 ,  C12N5/071 ,  C12N5/0735 ,  C12Q1/02

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K2039/505 ,  G01N2500/00

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断 ，PRO1114，PRO115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US07931902B2

公开(公告)日：2011-04-26

申请号：US11814549

申请日：2006-07-18

申请人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

发明人： Frederic J. de Sauvage ,  Gretchen Frantz ,  Charles Montgomery ,  Franklin Peale ,  Zheng-Zheng Shi ,  Mary Jean Sparks

IPC分类号： A01K67/00 ,  A61K39/395 ,  A61P43/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090293137A1

公开(公告)日：2009-11-26

申请号：US11814413

申请日：2006-11-16

申请人： Katherin E. Combs ,  Frederic J. de Sauvage ,  Liangfen Fan ,  Ellen Filvaroff ,  Allison A. B. Horner ,  Bryan Irving ,  Jagath Reddy Juntula ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Philips ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Teresa G. Townsend ,  Peter Vogel

发明人： Katherin E. Combs ,  Frederic J. de Sauvage ,  Liangfen Fan ,  Ellen Filvaroff ,  Allison A. B. Horner ,  Bryan Irving ,  Jagath Reddy Juntula ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Philips ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Teresa G. Townsend ,  Peter Vogel

IPC分类号： A01K67/027 ,  C12N5/06 ,  C07K16/18 ,  C12Q1/02 ,  A61K39/395

CPC分类号： C12Q1/6883 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008 ,  C12N15/8509 ,  C12Q2600/158

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO 1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO218，PRO228，PRO271，PRO273，PRO295，PRO302，PRO305，PRO326，PRO386，PRO655，PRO162，PRO788，PRO792，PRO940，PRO941，PRO1004，PRO1012，PRO1016，PRO474， PRO5238，PRO1069，PRO1111，PRO1113，PRO1130，PRO1195，PRO1271，PRO1865，PRO1879，PRO3446，PRO3543，PRO4329，PRO4352，PRO5733，PRO9859，PRO9864，PRO9904，PRO9907，PRO10013，PRO90948，PRO28694，PRO16089，PRO19563，PRO19675，PRO20084， PRO21434，PRO50332，PRO38465或PRO346基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20120272341A1

公开(公告)日：2012-10-25

申请号：US13473322

申请日：2012-05-16

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： G01N33/50 ,  C12Q1/02 ,  G01N33/92 ,  G01N33/483

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080124344A1

公开(公告)日：2008-05-29

申请号：US11814549

申请日：2006-07-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  A61P43/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。