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公开(公告)号：US20120065173A1
公开(公告)日：2012-03-15
申请号：US13224382
申请日：2011-09-02
Applicant: Markus Berger , Lena Bergström , Jan Dahmén , Anders Eriksson , Balint Gabos , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Stinabritt Nilsson , Camilla Taflin , Darren McKerrecher , Hartmut Rehwinkel
Inventor： Markus Berger , Lena Bergström , Jan Dahmén , Anders Eriksson , Balint Gabos , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Stinabritt Nilsson , Camilla Taflin , Darren McKerrecher , Hartmut Rehwinkel
IPC: A61K31/416 , C07D401/04 , A61K31/4439 , C07D401/12 , A61K31/4709 , C07D405/12 , C07D401/14 , A61K31/444 , C07D403/12 , A61K31/4178 , C07D413/12 , A61K31/422 , A61K31/56 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P37/06 , A61P11/00 , A61P17/00 , A61P17/06 , A61P17/04 , A61P1/16 , A61P1/00 , A61P27/02 , C07D231/56
CPC classification number: C07D231/56
Abstract: Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
Abstract translation: 式（I）化合物或其药学上可接受的盐; 包含它们的组合物，其制备方法及其在药物治疗中的用途（例如调节温血动物中的糖皮质激素受体）。
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公开(公告)号：US20100080786A1
公开(公告)日：2010-04-01
申请号：US12468494
申请日：2009-05-19
Applicant: Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Thomas Hansson , Nafizal Hossain , Henrik Johanssson , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
Inventor： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Thomas Hansson , Nafizal Hossain , Henrik Johanssson , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC: A61K38/55 , C07D403/10 , A61K31/416 , A61K31/4166 , A61K31/496 , A61K31/4427 , C07D401/10 , C07D401/14 , A61P11/06
CPC classification number: C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
Abstract: A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
Abstract translation: 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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![5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents](/abs-image/US/2009/05/28/US20090137564A1/abs.jpg.150x150.jpg)
23.发明申请5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US20090137564A1
公开(公告)日：2009-05-28
申请号：US12275392
申请日：2008-11-21
Applicant: Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorna Hassfeld , Heike Schacke
Inventor： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorna Hassfeld , Heike Schacke
IPC: A61K31/551 , C07D215/227 , A61K31/4704 , C07D303/32
CPC classification number: C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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24.发明申请CYCLIC PHENYL-SUBSTITUTED INDAZOLS, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开环状苯基取代的吲哚，其生产过程及其作为抗炎剂的用途公开(公告)号：US20080227820A1
公开(公告)日：2008-09-18
申请号：US11931090
申请日：2007-10-31
Applicant: Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
Inventor： Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
IPC: A61K31/4439 , A61P29/00 , C07D231/56 , C07D401/04 , A61K31/404 , C07D209/08 , C07D405/02 , A61K31/416
CPC classification number: C07D231/56 , C07D209/08 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14
Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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25.发明申请BENZYL AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 有权苯甲酰胺，其生产工艺及其作为抗炎剂的用途公开(公告)号：US20080032986A1
公开(公告)日：2008-02-07
申请号：US11777411
申请日：2007-07-13
Applicant: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schacke
Inventor： Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schacke
IPC: A61K31/135 , A61K31/4164 , A61K31/47 , A61K31/502 , A61K31/517 , A61P29/00 , C07C215/28 , C07D215/38 , C07D233/84 , C07D237/30 , C07D239/74 , C07D301/00 , C07D401/12 , C07D405/12
CPC classification number: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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Patent Agency Ranking
26.发明授权Benzoxazine and benzothiazine derivatives and the use thereof in medicaments 失效苯并恶嗪和苯并噻嗪衍生物及其在药物中的用途公开(公告)号：US07141566B1
公开(公告)日：2006-11-28
申请号：US10069284
申请日：2000-08-23
Applicant: Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
Inventor： Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
IPC: C07D265/36 , C07D498/04 , A61K31/538 , A61K31/5383
CPC classification number: C07D413/12 , C07D265/34 , C07D265/36
Abstract: The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
Abstract translation: 本发明涉及式（I）化合物，其互变异构体和异构体形式及其盐，除了其在药物中的生产和使用方法之外。
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27.发明申请Benzocycloheptene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开苯并环庚烯衍生物，其制备方法及其作为抗炎剂的用途公开(公告)号：US20060247292A1
公开(公告)日：2006-11-02
申请号：US11384809
申请日：2006-03-21
Applicant: Hartmut Rehwinkel , Duy Nguyen , Markus Berger , Heike Schaecke
Inventor： Hartmut Rehwinkel , Duy Nguyen , Markus Berger , Heike Schaecke
IPC: A61K31/415
CPC classification number: C07D209/34 , C07D215/22 , C07D231/56 , C07D403/04
Abstract: The invention relates to polysubstituted 5H-benzocycloheptene derivatives of formula (I) process for their production, and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式（I）的多取代的5H-苯并环庚烯衍生物的制备方法及其作为抗炎剂的用途。
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公开(公告)号：US07109212B2
公开(公告)日：2006-09-19
申请号：US11059682
申请日：2005-02-17
Applicant: Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Markus Berger , Hartmut Rehwinkel , Konrad Krolikiewicz , Werner Skuballa , Heike Schaecke , Arndt. J. G. Schottelius
Inventor： Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Markus Berger , Hartmut Rehwinkel , Konrad Krolikiewicz , Werner Skuballa , Heike Schaecke , Arndt. J. G. Schottelius
IPC: A61K31/47 , A61K31/472 , C07D217/24 , C07D217/00 , C07D215/38
CPC classification number: C07D405/12 , A61K31/47 , C07D215/40 , C07D217/24
Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
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29.发明申请公开(公告)号：US20050209324A1
公开(公告)日：2005-09-22
申请号：US10961406
申请日：2004-10-12
Applicant: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
Inventor： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC: A61K31/135 , A61K31/195 , A61K31/277
CPC classification number: C07D209/34 , C07D213/74 , C07D215/04 , C07D215/227 , C07D215/38 , C07D215/60 , C07D217/24 , C07D231/56 , C07D237/32 , C07D239/74 , C07D277/64 , C07D307/88 , C07D405/12 , C07D471/04
Abstract: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及四氢萘衍生物，其制备方法及其作为抗炎剂的用途。
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30.发明申请Rearranged pentanols, a process for their production and their use as anti-inflammatory agents 失效重排戊醇，其生产过程及其作为抗炎剂的用途公开(公告)号：US20050131226A1
公开(公告)日：2005-06-16
申请号：US10960757
申请日：2004-10-08
Applicant: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
Inventor： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC: A61P29/00 , C07D209/46 , C07D215/38 , C07D231/56 , C07D237/32 , C07D239/74 , C07D277/68 , C07D311/76 , C07D471/02 , C07D498/02
CPC classification number: C07D209/46 , C07D215/38 , C07D231/56 , C07D237/32 , C07D239/74 , C07D311/76
Abstract: The invention relates to the compounds of formula I, a process for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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