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公开(公告)号：US08636675B2
公开(公告)日：2014-01-28
申请号：US12901290
申请日：2010-10-08
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。
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公开(公告)号：US08394117B2
公开(公告)日：2013-03-12
申请号：US12040905
申请日：2008-03-02
申请人： Heinz-Michael Hein , Irio Calasso , Hans List
发明人： Heinz-Michael Hein , Irio Calasso , Hans List
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150068 , A61B5/150152 , A61B5/150175 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15123 , A61B5/1519 , A61B5/15194 , Y10T83/0481
摘要： The invention relates to a method for creating a puncture wound for obtaining a sample of a body fluid from a body part in which a skin opening is created at a puncture site in the epidermis in a skin-opening step. Then, in a sample collection step a sample collection puncture is executed by using a puncture element with which the skin opening is deepened with the puncture element, thereby creating a puncture wound for obtaining the sample. The invention also relates to a handheld apparatus for implementing this method.
摘要翻译： 本发明涉及一种创造穿刺伤口的方法，该穿刺伤口从皮肤开放步骤中在表皮的穿刺位置处产生皮肤开口的身体部位获得体液样品。 然后，在取样步骤中，通过使用与穿刺元件加深皮肤开口的穿刺元件进行样本采集穿刺，由此形成用于获取样本的穿刺伤口。 本发明还涉及一种用于实现该方法的手持设备。
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公开(公告)号：US08313652B2
公开(公告)日：2012-11-20
申请号：US12617530
申请日：2009-11-12
IPC分类号： B03C1/01
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , Y10T436/111666
摘要： The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.
摘要翻译： 本发明包括容器和使用离心力分离一个或多个与磁性颗粒结合的组分的方法。
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公开(公告)号：US07833172B2
公开(公告)日：2010-11-16
申请号：US11868505
申请日：2007-10-07
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。
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25.发明授权Method and device for determining a light transport parameter in a biological matrix 有权用于确定生物矩阵中的光传输参数的方法和装置公开(公告)号：US07315752B2
公开(公告)日：2008-01-01
申请号：US10499109
申请日：2002-12-07
申请人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
发明人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A method for the selective determination of the scattering index μs of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (ρ) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of μs, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element. In at least two detection measurements, the measuring distance (ρ) between the respective light irradiation site (10) and the respective detection site (33-40) corresponds to no more than five times the mean free path length of the light propagating in the biological matrix.
摘要翻译： 用于通过检测测量法选择性地确定散射生物基质的散射指数的方法，特别是用于非侵入性地测定皮肤中葡萄糖浓度的目的， 其中以原色光（9）的形式的光照射到生物基质（5）中，并且在位于不同测量点处的检测位置（33-40）处出射的次级光（12）的强度测量值 在检测测量期间测量来自相应的光照射部位（10）的距离（rho）。 为了提高测定的质量和选择性，使用接触光引导元件以5°和85°之间的角度倾斜地照射一次光。 在至少两次检测测量中，相应的光照射部位（10）和各个检测部位（33-40）之间的测量距离（rho）对应于不超过在 生物基质。
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26.发明申请Method and device for determining a light transport parameter in a biological matrix 有权用于确定生物矩阵中的光传输参数的方法和装置公开(公告)号：US20050002031A1
公开(公告)日：2005-01-06
申请号：US10499109
申请日：2002-12-07
申请人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
发明人： Uwe Kraemer , Heinz-Michael Hein , Marcus Hermann
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： A method for the selective determination of the scattering index μs of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (ρ) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of μs, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element. In at least two detection measurements, the measuring distance (ρ) between the respective light irradiation site (10) and the respective detection site (33-40) corresponds to no more than five times the mean free path length of the light propagating in the biological matrix.
摘要翻译： 一种用于选择性地确定散射生物基质的散射指数的方法，特别是通过检测测量来非侵入性地测定皮肤中葡萄糖浓度的目的，其中每种形式的光都是 的初级光（9）照射到生物基质（5）中，并且从位于与各个光的不同测量距离（rho）处的检测位置（33-40）处出射的次级光（12）的强度测量值 在检测测量期间测量照射部位（10）。 为了提高测定的质量和选择性，使用接触光引导元件以5°和85°之间的角度倾斜地照射一次光。 在至少两次检测测量中，相应的光照射部位（10）和各个检测部位（33-40）之间的测量距离（rho）对应于不超过在 生物基质。
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27.发明授权公开(公告)号：US07369952B2
公开(公告)日：2008-05-06
申请号：US10552248
申请日：2004-04-06
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译： 本发明涉及用于诊断人和动物样品疾病的分析方法。 本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。 所述发明还能够以早期的方式鉴定疾病并进行治疗控制。 本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。 然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。
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公开(公告)号：US20060195296A1
公开(公告)日：2006-08-31
申请号：US10552248
申请日：2004-04-06
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译： 本发明涉及用于诊断人和动物样品疾病的分析方法。 本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。 所述发明还能够以早期的方式鉴定疾病并进行治疗控制。 本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。 然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。
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