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    System for the analysis of liquid samples
    1.
    发明授权
    System for the analysis of liquid samples 有权
    液体样品分析系统

    公开(公告)号：US08940249B2

    公开(公告)日：2015-01-27

    申请号：US12850934

    申请日：2010-08-05

    申请人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    发明人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    IPC分类号： G01N35/08 ,  G01N35/10 ,  G01N35/00

    CPC分类号： G01N35/1095 ,  B01L2200/027 ,  G01N35/085 ,  G01N2035/00158 ,  G01N2035/1034

    摘要： A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

    摘要翻译： 公开了一种用于自动分析液体样品的系统，该液体样品具有一个或多个处理单元，用于样品与一种或多种试剂之间的反应，从而获得反应产物。 还公开了一种用于将样本提供给一个或多个处理单元的采样单元; 配备有多个试剂容器的试剂单元，所述试剂容器含有一种或多种用于与样品混合的试剂; 用于分配流体的分配单元，所述流体包括具有多个分配管线的一种或多种试剂，其中至少一些连接到所述试剂容器和所述一个或多个处理单元; 以及用于基于反应产物分析样品的至少一个分析单元，其中分析单元可以包括用于检测反应产物的至少一个检测器。

    Method and aparatus for determining an analyte in a biological sample
    5.
    发明授权
    Method and aparatus for determining an analyte in a biological sample 失效
    用于测定生物样品中分析物的方法和装置

    公开(公告)号：US5770454A

    公开(公告)日：1998-06-23

    申请号：US737135

    申请日：1996-11-07

    申请人： Matthias Essenpreis ,  Dirk Boecker ,  Heinz-Michael Hein ,  Hans-Peter Haar

    发明人： Matthias Essenpreis ,  Dirk Boecker ,  Heinz-Michael Hein ,  Hans-Peter Haar

    IPC分类号： A61B5/00 ,  G01N21/49 ,  G01N21/00

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/49 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043

    摘要： A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two detection measurements, with each detection measurement including the step of irradiating light at an irradiation site as primary light into the biological sample through a boundary surface. The light is propagated along a light path, and light is detected as it emerges from the biological sample as secondary light through a detection site. The irradiation site and detection site are separated by a measuring distance. At least two detection measurements are performed with at least two different measurement light paths between the irradiation site and the detection site. Each of the detection measurements is a frequency-domain spectroscopic measurement which is performed at at least two different wavelengths of light, and includes a comparison of a phase shift of the secondary light with the primary light as a first measurement variable, and an intensity of the secondary light as a second measurement variable. The method also includes the steps of determining the analyte concentration based upon the first and second measurement variables.

    摘要翻译： PCT No.PCT / DE95 / 00593 Sec。 371日期：1996年11月7日 102（e）日期1996年11月7日PCT提交1995年5月3日PCT公布。 公开号WO95 / 32416 PCT 日期：1995年11月30日用于分析生物样品中分析物浓度的方法和装置包括执行至少两次检测测量的一系列硬件元件和方法步骤，每个检测测量包括将光照射到 照射部位作为通过边界表面进入生物样品的初级光。 光沿光路传播，当从生物样品出现时，通过检测部位作为二次光检测出光。 照射部位和检测部位通过测量距离分开。 在照射部位和检测部位之间至少有两个不同的测量光路进行至少两次检测测量。 每个检测测量是在至少两个不同波长的光下执行的频域光谱测量，并且包括将次级光与初级光的相移作为第一测量变量的比较，以及 次光作为第二测量变量。 该方法还包括基于第一和第二测量变量确定分析物浓度的步骤。

    System For The Analysis Of Liquid Samples
    6.
    发明申请
    System For The Analysis Of Liquid Samples 有权
    液体样品分析系统

    公开(公告)号：US20110189052A1

    公开(公告)日：2011-08-04

    申请号：US12850934

    申请日：2010-08-05

    申请人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    发明人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    IPC分类号： G01N33/00

    CPC分类号： G01N35/1095 ,  B01L2200/027 ,  G01N35/085 ,  G01N2035/00158 ,  G01N2035/1034

    摘要： A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

    摘要翻译： 公开了一种用于自动分析液体样品的系统，该液体样品具有一个或多个处理单元，用于样品与一种或多种试剂之间的反应，从而获得反应产物。 还公开了一种用于将样本提供给一个或多个处理单元的采样单元; 配备有多个试剂容器的试剂单元，所述试剂容器含有一种或多种用于与样品混合的试剂; 用于分配流体的分配单元，所述流体包括具有多个分配管线的一种或多种试剂，其中至少一些连接到所述试剂容器和所述一个或多个处理单元; 以及用于基于反应产物分析样品的至少一个分析单元，其中分析单元可以包括用于检测反应产物的至少一个检测器。

    Method for the determination of a light transport parameter in a biological matrix
    7.
    发明授权
    Method for the determination of a light transport parameter in a biological matrix 失效
    用于确定生物基质中光传输参数的方法

    公开(公告)号：US07565249B2

    公开(公告)日：2009-07-21

    申请号：US10471113

    申请日：2002-02-23

    申请人： Uwe Kraemer ,  Heinz-Michael Hein ,  Dietmar Volz

    发明人： Uwe Kraemer ,  Heinz-Michael Hein ,  Dietmar Volz

    IPC分类号： G06F19/00 ,  G11C17/00 ,  G01N33/66

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2562/0242 ,  Y10T436/144444

    摘要： A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (5), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values. For the selective determination of the scattering coefficient, the evaluation algorithm includes a step in which a time derivative value ΔtI(r) describing the change of the measurement intensity value versus time is calculated from intensity measurement values obtained at a minimum of two different points of time.

    摘要翻译： 提出了一种用于选择性确定生物基质（5）中的光散射特征的光传输参数的方法，特别是为了非侵入性地确定生物基质中的葡萄糖浓度。 该方法包括提供多个检测测量，其中将光作为初级光照射到生物矩阵中并测量出位于与照射部位不同的测量距离的多个检测位置的二次光的强度值。 在评估步骤中，通过评估算法从测量的强度值导出光传输参数。 为了选择性地确定散射系数，评估算法包括一个步骤，其中描述测量强度值与时间的变化的时间导数值DeltatI（r）是从在两个不同点的最小两点获得的强度测量值计算的 时间。