公开(公告)号：US06255477B1

公开(公告)日：2001-07-03

申请号：US08952969

申请日：1998-03-11

申请人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

发明人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

IPC分类号： C12N1500

CPC分类号： C03C3/111 ,  B03C1/01 ,  B82Y25/00 ,  C03C3/078 ,  C03C3/083 ,  C03C3/085 ,  C03C3/087 ,  C03C3/089 ,  C03C3/091 ,  C03C3/102 ,  C03C3/105 ,  C03C3/108 ,  C07H21/00 ,  C12N15/1013 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6834 ,  H01F1/0063 ,  H01F1/112 ,  H01F1/36 ,  Y10S428/90 ,  Y10S435/814 ,  Y10T428/2996

摘要： Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3. In using the magnetic glass particles to separate a biological material, the particles are contacted with a fluid containing the biological material such that the biological material binds to the glass surface, and the bound biological material is separated from the fluid such as by using a magnetic field. Before applying a magnetic field, the magnetic particles may sediment when contacted with the biological material.

摘要翻译： 制备磁性玻璃颗粒，其包含涂覆有具有基本无孔玻璃表面的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm，并且玻璃表面的任何孔具有小于10nm的直径。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。 在使用磁性玻璃颗粒分离生物材料时，颗粒与包含生物材料的流体接触，使得生物材料结合到玻璃表面，并且结合的生物材料与流体分离，例如通过使用磁性 领域。 在施加磁场之前，当与生物材料接触时，磁性颗粒可能沉淀。

公开(公告)号：US08945022B2

公开(公告)日：2015-02-03

申请号：US12577570

申请日：2009-10-12

申请人： Ahmet Konya ,  Klaus Schoettle ,  Herbert Harttig

发明人： Ahmet Konya ,  Klaus Schoettle ,  Herbert Harttig

IPC分类号： A61B5/15 ,  A61B5/151 ,  A61B5/155 ,  A61B5/157 ,  A61B5/145

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15113 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/157 ,  A61B2562/0295

摘要： A puncturing system for obtaining a sample of body fluid comprises a magazine that comprises a lancet carrier that carries several lancets, a puncturing device comprising a compartment for the magazine, an incremental advancing mechanism for moving the lancets successively to a puncturing position, and a puncturing drive for accelerating one of the lancets that is positioned in the puncturing position in a puncturing motion. The magazine comprises a coupling facility with a receptacle for the lancet carrier. The receptacle is mobile with respect to a magazine housing The lancets that are carried by the lancet carrier can be moved relative to the receptacle by actuating the incremental advancing mechanism The receptacle is adapted to couple the puncturing drive to one of the lancets positioned in the puncturing position for transmitting a driving force generated by the puncturing drive during a puncture to the lancet positioned in the puncturing position.

摘要翻译： 一种用于获取体液样本的穿刺系统，包括一个盒子，该盒子包括一个承载多个刺血针的刺血针架，一个穿刺装置，包括一个用于刀库的隔间，一个用于将刺血针相继移动到穿刺位置的增量推进机构， 用于加速穿刺运动中位于穿刺位置的一个刺血针的驱动装置。 该杂志包括具有用于刺血针架的插座的联接设备。 容器相对于药盒外壳是可移动的。由柳叶刀托架承载的刺血针可以通过致动增量推进机构而相对于容器移动。该插座适于将穿刺驱动器连接到位于穿刺中的一个刺血针 在穿刺期间将由穿刺驱动产生的驱动力传递到位于穿刺位置的刺血针的位置。

公开(公告)号：US08753289B2

公开(公告)日：2014-06-17

申请号：US12619420

申请日：2009-11-16

申请人： Ahmet Konya ,  Herbert Harttig

发明人： Ahmet Konya ,  Herbert Harttig

IPC分类号： A61B5/00 ,  A61B17/14 ,  A61B17/32

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/15146

摘要： A pricking system includes lancets for producing a prick wound, sampling devices for collecting a sample of a body fluid from the prick wound, a housing having an opening for application of a body part in which the prick wound is to be produced, a drive arranged in the housing for moving one of the lancets to produce the prick wound and to then move one of the sampling devices to the prick wound so produced, a coupling part for coupling to the drive one of the lancets for a pricking movement and then coupling to the drive one of the sampling devices for a sampling movement, the coupling part being moved, during the pricking movement and the sampling movement, respectively, from a starting position into an end position by an advancing movement, and from the end position back into the starting position by a reversing movement, respectively, and a motion control which, during the sampling movement, causes the coupling part to reach an end position that differs from the end position reached by the coupling part during the pricking movement, wherein the end position reached by the coupling part in the sampling movement is laterally displaced relative to the end position reached by the coupling part in the prickling movement.

摘要翻译： 穿刺系统包括用于产生刺伤的刺血针，用于从刺伤缠绕收集体液样本的取样装置，具有用于施加要产生刺伤的身体部位的开口的壳体，布置成 在用于移动其中一个刺血针以产生刺伤并且然后将其中一个取样装置移动到如此产生的刺伤的壳体中的一个联接部分，用于联接到驱动器之一的刺血针用于穿刺运动，然后耦合到 用于采样运动的采样装置中的一个驱动器，耦合部分在穿刺运动和采样运动期间分别从进位运动的起始位置移动到结束位置，并且从终端位置返回到 分别通过反转运动的起始位置和运动控制，在运动控制期间，在取样运动期间，使联接部件到达不同于最终位置的终点位置 d，其中在取样运动中由联接部件到达的端部位置相对于穿刺运动中的联接部件所达到的端部位置横向移位。

公开(公告)号：US08586376B2

公开(公告)日：2013-11-19

申请号：US13332076

申请日：2011-12-20

申请人： Herbert Harttig ,  Bernd Hiller ,  Wolfgang Schwoebel ,  Alexander Kasejew

发明人： Herbert Harttig ,  Bernd Hiller ,  Wolfgang Schwoebel ,  Alexander Kasejew

IPC分类号： G01N21/75

CPC分类号： G01N33/521 ,  B01D69/02 ,  B01D69/06 ,  B01D69/10 ,  B01D69/105 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/42 ,  B01D2325/02 ,  B01D2325/36 ,  Y10T83/0267 ,  Y10T83/0296

摘要： Methods of producing an analysis spreading layer for absorbing a liquid to be analyzed, by: supplying a porous membrane having a bottom, a top and a thickness D, the size of the pores of the membrane increasing over its thickness D; cutting the membrane at a predefined distance, the spreading layer being a sublayer with a thickness d less than the starting thickness D, the pores of the spreading layer having a fluid connection to one another in such a manner that it is permeable to a liquid. The membrane surface is formed by removing a sublayer of the membrane being the liquid outlet side of the spreading layer. The mean size of the pores on the liquid outlet side is at least 1 μm.

摘要翻译： 制造用于吸收待分析液体的分析扩散层的方法，通过以下步骤：提供具有底部，顶部和厚度D的多孔膜，膜的孔的尺寸增加其厚度D; 以预定的距离切割膜，扩散层是厚度d小于起始厚度D的子层，扩散层的孔以可渗透液体的方式彼此流体连接。 通过除去作为扩散层的液体出口侧的膜的子层来形成膜表面。 液体出口侧的孔的平均尺寸至少为1um。

公开(公告)号：US08496602B2

公开(公告)日：2013-07-30

申请号：US12753454

申请日：2010-04-02

申请人： Herbert Harttig ,  Jürgen Braun

发明人： Herbert Harttig ,  Jürgen Braun

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： A61B5/15128 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150183 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B2562/0295

摘要： An automatic apparatus for obtaining and analyzing a blood sample contains a supply of lancets and test strips, which are located alternately on a carrier band. A lancet or alternatively a test strip may be clamped on a holder, which is mounted so it is movable. The movement controller of the holder comprises a three-dimensional control curve and a guide element, which engages at different depths in the control curve as a function of its relative position. The control curve comprises two guide paths, which run on different parallel planes. The contour of the first guide path determines the movement path of the lancet and the contour of the second guide path determines the movement path of the test strip. The test strip executes a transverse offset perpendicular to the puncture axis of the lancet.

公开(公告)号：US08448866B2

公开(公告)日：2013-05-28

申请号：US12197806

申请日：2008-08-25

申请人： Herbert Harttig ,  Hans List ,  Bernd Roesicke ,  Gerrit Kocherscheidt ,  Bruno Thoes ,  Jean-Michel Asfour

发明人： Herbert Harttig ,  Hans List ,  Bernd Roesicke ,  Gerrit Kocherscheidt ,  Bruno Thoes ,  Jean-Michel Asfour

IPC分类号： G06K7/10

CPC分类号： G06K19/06037 ,  G01N35/00732 ,  G06K7/1417 ,  G06K7/1443 ,  G06K7/1473 ,  G06K19/06046

摘要： An arrangement is provided for reading information from a disposable with an information carrier which comprises a code formed by graphic symbols for the machine-readable provision of information and an optical reading device for the code which has a light source and a sensor. Generally according to the embodiments of the present invention, the information carrier comprises a code applied to a transparent or translucent substrate which can be read under stationary transillumination by means of the light source as a shadow image projected onto the sensor.

摘要翻译： 提供了一种用于从具有信息载体的一次性的信息读取信息的装置，该信息载体包括由用于机器可读提供信息的图形符号形成的代码和用于具有光源和传感器的代码的光学读取装置。 通常根据本发明的实施例，信息载体包括应用于透明或半透明衬底的代码，其可以通过作为投影到传感器上的影像的光源在静态透照下进行读取。

公开(公告)号：US08444574B2

公开(公告)日：2013-05-21

申请号：US12396838

申请日：2009-03-03

申请人： Hans List ,  Irio G. Calasso ,  Joachim Hoenes ,  Hans-Peter Haar ,  Uwe Kraemer ,  Herbert Harttig ,  Volker Zimmer

发明人： Hans List ,  Irio G. Calasso ,  Joachim Hoenes ,  Hans-Peter Haar ,  Uwe Kraemer ,  Herbert Harttig ,  Volker Zimmer

IPC分类号： A61B5/00 ,  A61B17/32 ,  A61B17/14 ,  B65D81/00

CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150175 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15132

摘要： Lancing system comprising a needle and a lancing device The lancing device comprises a housing with a housing opening that is surrounded by a housing skin contact surface. A lancing depth reference element with a reference skin contact surface is adapted in such a manner that the reference skin contact surface at a reversal point of the lancing movement is in contact with the skin. The lancing depth is determined by the distance between the reference skin contact surface and the tip of the needle element at the reversal point of the lancing movement. The lancing depth reference element is in a stationary defined position relative to the reversal point of the lancing movement. The lancing depth reference element is adapted to stabilize the skin when pressed against the reference skin contact surface with respect to a skin deformation which occurs upon lancing of the skin.

摘要翻译： 包括针和穿刺装置的牵引系统。该穿刺装置包括壳体，该外壳具有由壳体皮肤接触表面包围的壳体开口。 具有参考皮肤接触表面的穿刺深度参考元件以使得在穿刺运动的反转点处的参考皮肤接触表面与皮肤接触的方式被适配。 穿刺深度由穿刺运动的反转点处的参考皮肤接触表面和针元件的尖端之间的距离确定。 穿刺深度参考元件相对于穿刺运动的反转点处于静止的限定位置。 穿刺深度参考元件适于当相对于在皮肤穿刺时发生的皮肤变形而压靠参照皮肤接触表面时稳定皮肤。

公开(公告)号：US08404478B2

公开(公告)日：2013-03-26

申请号：US13205886

申请日：2011-08-09

申请人： Herbert Harttig ,  Josef Roeper ,  Otto Fuerst ,  Thomas Jaeck ,  Ralf Dagenbach ,  Juergen Braun ,  Ronald Moench ,  Hans List ,  Beate Koschorreck

发明人： Herbert Harttig ,  Josef Roeper ,  Otto Fuerst ,  Thomas Jaeck ,  Ralf Dagenbach ,  Juergen Braun ,  Ronald Moench ,  Hans List ,  Beate Koschorreck

IPC分类号： C12M1/34 ,  C12M3/00 ,  G01N21/62 ,  G01N33/558

CPC分类号： G01N33/48764 ,  B01L3/5023 ,  B01L2200/12 ,  B01L2300/0825 ,  B01L2300/0887 ,  G01N21/898

摘要： A diagnostic test tape for liquid samples is provided comprising a flexible transport tape and a plurality of test fields applied to the transport tape that are distributed in the longitudinal direction of the tape, where said test fields comprise a detection layer and a spreading net spanning the detection layer for a planar uptake of liquid sample, wherein the spreading net is formed from a lattice-like fabric comprising fabric threads that cross at right angles. In order to prevent the fabric from arching up under tape tension it is proposed that the fabric is oriented obliquely to the transport tape such that all fabric threads run obliquely to the longitudinal direction of the tape.

摘要翻译： 提供了用于液体样品的诊断测试带，其包括柔性输送带和应用于输送带的多个测试区域，所述测试区域沿着带的纵向方向分布，其中所述测试区域包括检测层和跨越 用于液体样品的平面摄取的检测层，其中所述铺展网由包括以直角交叉的织物线的格子状织物形成。 为了防止织物在带张力下弯曲，建议织物相对于输送带倾斜地定向，使得所有织物线沿着带的纵向倾斜地延伸。

公开(公告)号：US08221333B2

公开(公告)日：2012-07-17

申请号：US12726752

申请日：2010-03-18

申请人： Herbert Harttig

发明人： Herbert Harttig

IPC分类号： A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  G01N35/00

CPC分类号： A61B5/15146 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/157 ,  Y10T436/110833

摘要： A puncturing system includes a support tape (1) that supports a plurality of lancets (2), a first reel (3) onto which the support tape (1) with unused lancets (2) is wound, a second reel (4) on which portions of the support tape with used lancets (2) are to be wound, a winding mechanism which, by turning the second reel (4), brings the lancets (2) supported by the support tape (1) to a position of use one after another and thus unwinds the support tape (1) from the first reel (3) and winds it onto the second reel (4), and a puncturing drive mechanism (7) with which lancets (2) located in the position of use are accelerated in order to puncture the skin. The support tape (1) between the first and second reels (3, 4) is twisted only in one direction of rotation by at least a quarter turn, preferably by at least a half turn.

摘要翻译： 一种穿刺系统，包括支撑多个刺血针（2）的支撑带（1），其上缠绕有未使用的柳叶刀（2）的支撑带（1）的第一卷轴（3），第二卷轴 具有用于使用的刺血针（2）的支撑带的哪个部分被卷绕，通过转动第二卷轴（4）将由支撑带（1）支撑的刺血针（2）带到使用位置的卷绕机构 从而使第一卷轴（3）上的支撑带（1）展开并将其卷绕到第二卷轴（4）上，以及穿刺驱动机构（7），刺血针（2）位于使用位置 加速以刺穿皮肤。 第一和第二卷轴（3,4）之间的支撑带（1）仅在一个旋转方向上扭转至少四分之一圈，优选地至少半圈。

公开(公告)号：US20110212532A1

公开(公告)日：2011-09-01

申请号：US13104575

申请日：2011-05-10

申请人： Herbert Harttig

发明人： Herbert Harttig

IPC分类号： G01N33/66

CPC分类号： G01N33/4875 ,  Y10T436/144444

摘要： An analytical system comprising a replaceable magazine (12) for providing a plurality of test units that react to an analyte and a measuring device (14) for processing the test units, wherein the magazine (12) is provided with a code (26) that can be registered by the measuring device (14). In order to enable the simplest possible coding, it is proposed that the code (26) comprises an unique magazine identifier (28) for the magazine (12) and that the measuring device (14) has a magazine-independent test counter (16) which registers the processing of a test unit and a counter memory (18) to store the magazine identifier (28) and a corresponding count of the test counter (16).

摘要翻译： 一种分析系统，包括用于提供与分析物反应的多个测试单元和用于处理所述测试单元的测量装置（14）的可替换盒（12），其中所述盒（12）设置有代码（26），所述代码 可以由测量装置（14）登记。 为了实现最简单的可能的编码，提出了代码（26）包括用于盒（12）的唯一杂志标识符（28），并且测量装置（14）具有独立于杂志的测试计数器（16） 其记录测试单元和计数器存储器（18）的处理，以存储盒标识符（28）和测试计数器（16）的相应计数。