公开(公告)号：US20230016954A1

公开(公告)日：2023-01-19

申请号：US17781704

申请日：2020-12-10

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shani Shenhar-Tsarfaty ,  Shlomo Avraham Berliner ,  Ori Rogowski ,  Eyal Fisher ,  Adi Silberman

IPC: G01N33/569

Abstract: The invention provides assays and methods for diagnosing and treating infectious diseases. The invention relates in some embodiments to urinary biomarkers and their use in the differential diagnosis of bacterial and viral infections. The invention further relates to means for determining and providing correct treatment to infection in a non-invasive manner, while minimizing antibiotic misuse.

公开(公告)号：US20230002726A1

公开(公告)日：2023-01-05

申请号：US17903271

申请日：2022-09-06

Applicant: ICHILOV TECH LTD.

Inventor： Nadir ARBER ,  Shiran SHAPIRA ,  Oren BOGIN

IPC: C12N5/073 ,  C12N5/00 ,  G01N33/50

Abstract: Xenograft egg models comprising a fertilized non-mammalian egg comprising an ablated immune system, a first plurality of mammalian cells and a second plurality of mammalian cells, wherein the second plurality comprises immune cells are provided. Methods of producing the xenograft egg model as well as using the xenograft egg model for screening are also provided.

公开(公告)号：US20220220135A1

公开(公告)日：2022-07-14

申请号：US17604698

申请日：2020-04-18

Applicant: BAR-ILAN UNIVERSITY ,  ICHILOV TECH LTD ,  LAVAL UNIVERSITY ,  UNIVERSITY OF BONN

Inventor： Hana Bilha FISCHER ,  Molhm NASSIR ,  Vadim ZELIKMAN ,  Uri Moshe ARAD ,  Jean SEVIGNY ,  Christa MULLER

IPC: C07F9/6561 ,  C07H19/20

Abstract: The invention relates to a novel highly selective and potent NPP1 inhibitors, compositions comprising such, and their use as pharmaceuticals.

公开(公告)号：US20240002810A1

公开(公告)日：2024-01-04

申请号：US18224131

申请日：2023-07-20

Applicant: Ichilov Tech Ltd.

Inventor： Nadir ARBER ,  Shiran SHAPIRA

IPC: C12N5/071 ,  C12N5/077 ,  C07K14/71

CPC classification number: C12N5/0686 ,  C12N5/0656 ,  C07K14/71 ,  C12N2501/998 ,  C12N2500/90 ,  C12N2501/33 ,  C12N2501/599

Abstract: A method of producing cell derived particles is disclosed. The method comprising isolating cell-derived particles from a biological sample comprising cells modified to present CD24 so as to obtain a preparation of the cell-derived particles substantially devoid of intact cells. Cell derived particles, a culture medium and a cell culture are also disclosed.

公开(公告)号：US20230394655A1

公开(公告)日：2023-12-07

申请号：US18236007

申请日：2023-08-21

Applicant: ICHILOV TECH LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Dafna BEN BASHAT ,  Liat BEN SIRA ,  Daphna LINK ,  Netanell AVISDRIS ,  Leo JOSKOWICZ

IPC: G06T7/00 ,  G16H50/20

CPC classification number: G06T7/0012 ,  G16H50/20 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/30016

Abstract: A system and method of predicting a condition of a fetus may include receiving a magnetic resonance imaging (MRI) scan of the fetus, comprising a sequence of slices; detecting a volume of interest (VOI) representing a location of a brain of the fetus; segmenting one or more slices comprised in the VOI to a set of brain structures selected from a right hemisphere, a left hemisphere, a right lateral ventricle, and a left lateral ventricle; based on said segmentation, calculating at least one ventricle; and predicting a condition of the fetus based on the at least one ventricle metric.

公开(公告)号：US20230285383A1

公开(公告)日：2023-09-14

申请号：US18130943

申请日：2023-04-05

Applicant: Ichilov Tech Ltd.

Inventor： Eli SPRECHER ,  Ofer SARIG

IPC: A61K31/4745 ,  A61P17/06 ,  A61P29/00 ,  A61K9/00

CPC classification number: A61K31/4745 ,  A61P17/06 ,  A61P29/00 ,  A61K9/0014

Abstract: Compounds represented by Formula A as defined in the specification for use in treating skin diseases such as, for example, psoriasis, or atopic dermatitis, in a subject in need thereof are disclosed. Compositions containing these compounds, formulated for topical application, are also disclosed.

公开(公告)号：US20230272484A1

公开(公告)日：2023-08-31

申请号：US18142618

申请日：2023-05-03

Applicant: Yeda Research and Development Co. Ltd. ,  Ichilov Tech Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Mor ZADA ,  Chamutal BORNSTEIN-OVITS ,  Shuang-Yin WANG ,  Yael COHEN

IPC: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: A method of prognosing a subject diagnosed with multiple myeloma (MM) is provided. Also provided a method of treating a subject diagnosed with MM selected expressing intracellular PPIA and/or RRM2 above a predetermined threshold, the method comprising administering to the subject a therapeutically effective amount of at least one agent which specifically down-regulates activity or expression of PPIA and/or RRM2, thereby treating the subject.

公开(公告)号：US20230233618A1

公开(公告)日：2023-07-27

申请号：US18114317

申请日：2023-02-27

Applicant: Ichilov Tech Ltd.

Inventor： Nadir ARBER ,  Shiran SHAPIRA

IPC: A61K35/33 ,  A61P37/06 ,  A61P31/14 ,  A61P11/00 ,  A61K9/00 ,  A61K9/127 ,  A61K38/17 ,  C12N5/077

CPC classification number: A61K35/33 ,  A61P37/06 ,  A61P31/14 ,  A61P11/00 ,  A61K9/0043 ,  A61K9/007 ,  A61K9/1271 ,  A61K38/177 ,  C12N5/0656 ,  C12N2510/00

Abstract: A composition comprising cell-derived particles presenting heterologous CD24, wherein the cell is a non-cancerous cell and wherein the composition is substantially devoid of intact cells is disclosed. Methods of producing the cell-derived particles and methods of using the cell-derived particles in treatment of cytokine storm syndrome, tissue injury associated with the inflammation and Coronavirus infection are also disclosed.

公开(公告)号：US20230123617A1

公开(公告)日：2023-04-20

申请号：US18085700

申请日：2022-12-21

Applicant: Ichilov Tech Ltd. ,  Ramot at Tel-Aviv University Ltd. ,  The Royal Institution For The Advancement Of Learning/McGill University

Inventor： Talma HENDLER ,  Neomi SINGER ,  Robert ZATORRE ,  Alain DAGHER ,  Marcel FARRES-FRANCH

IPC: A61B5/375 ,  A61B5/38 ,  A61B5/372 ,  G16H20/30 ,  G01R33/48

Abstract: A neurofeedback method, including: recording electrical signals from at least one brain region of a subject, wherein changes in the recorded electrical signals over time indicate changes in an activity level of the at least one brain region; providing an audio signal having a perceived quality based on the recorded electrical signals and according to an activity level of the at least one brain region; delivering the audio signal to the subject during said recording.

公开(公告)号：US20220226348A1

公开(公告)日：2022-07-21

申请号：US17610276

申请日：2020-05-13

Applicant: ICHILOV TECH LTD ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Eli SPRECHER ,  Ofer SARIG ,  Janan MOHAMAD ,  Alon PELED

IPC: A61K31/56 ,  A61K9/00 ,  A61K47/06 ,  A61P17/00

Abstract: The present invention provides a method and a pharmaceutical composition for treatment of skin diseases associated with accelerated comeodesmosomes degradation and/or weaker cell-cell adhesion, such as a peeling skin syndrome, Netherton syndrome, and atopic dermatitis.