公开(公告)号：US10544445B2

公开(公告)日：2020-01-28

申请号：US15681078

申请日：2017-08-18

Applicant: InnovaPrep LLC

Inventor： David S. Alburty ,  Andrew E. Page ,  Zachary A. Packingham ,  Daniel B. Marske

IPC: C12Q1/24 ,  G01N1/40 ,  C12Q1/04

Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.

公开(公告)号：US20170369925A1

公开(公告)日：2017-12-28

申请号：US15681078

申请日：2017-08-18

Applicant: InnovaPrep LLC

Inventor： David S. Alburty ,  Andrew E. Page ,  Zachary A. Packingham ,  Daniel B. Marske

IPC: C12Q1/24 ,  C12Q1/04 ,  G01N1/40

CPC classification number: C12Q1/24 ,  C12Q1/04 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.

公开(公告)号：US20170184478A1

公开(公告)日：2017-06-29

申请号：US15456981

申请日：2017-03-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/40 ,  C12Q1/24

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

公开(公告)号：US09534989B2

公开(公告)日：2017-01-03

申请号：US14084403

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  David Scott Alburty ,  Alec D. Adolphson ,  Pamela S. Murowchick ,  Zachary A. Packingham

IPC: G01N1/22 ,  G01N1/40

CPC classification number: G01N1/4077 ,  B01D46/0032 ,  B01D46/0067 ,  B01D46/543 ,  G01N1/2205 ,  G01N1/2273 ,  G01N2001/4088

Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.

Abstract translation: 公开了涉及使用湿泡沫洗脱法从扁平过滤器去除颗粒的装置，系统和方法。 颗粒从大气中捕获到扁平过滤器上。 然后将扁平过滤器放入提取器中，该提取器将湿泡沫流通过扁平过滤器。 泡沫的膨胀用于有效去除捕获的颗粒。 泡沫从捕获的颗粒与过滤器一起流入样品容器。 一旦在样品容器中，泡沫快速分解，留下分析就绪的液体样品。

公开(公告)号：US11839837B2

公开(公告)日：2023-12-12

申请号：US17209420

申请日：2021-03-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: A47G19/22 ,  B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  C12H1/18 ,  A23L5/20 ,  G01N33/14

CPC classification number: B01D19/0073 ,  A23L5/21 ,  A47G19/22 ,  A47G19/2233 ,  B01D19/00 ,  C12H1/18 ,  G01N1/4005 ,  G01N1/4055 ,  G01N1/42 ,  G01N33/146 ,  A23V2002/00

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US20230358153A1

公开(公告)日：2023-11-09

申请号：US18135104

申请日：2023-04-14

Applicant: INNOVAPREP LLC

Inventor： Steven D. Graham ,  Alec Adolphson ,  Bryan Long

IPC: F01N1/08 ,  F01N1/10 ,  F01N13/00

CPC classification number: F01N1/083 ,  F01N1/10 ,  F01N13/002

Abstract: Devices, systems and methods are described for reducing noise emitted from active aerosol and bioaerosol collection devices. The system includes a noise reducing muffler between the collection component and the air mover and a noise reducing baffle at the outlet of the air mover. The muffler reduces higher frequency noises emitted from the air mover inlet while the baffle reduces lower frequency noises emitted from the air mover outlet. Placement of the muffler between the collection component and the air mover eliminates the potential for loss of particles to the muffler prior to collection.

公开(公告)号：US20230146816A1

公开(公告)日：2023-05-11

申请号：US17984204

申请日：2022-11-09

Applicant: INNOVAPREP LLC

Inventor： Michael Fischer ,  Bryan Long ,  Steven D. Graham ,  Sidney J. Spry ,  Alec Adolphson ,  John D. Birkenholz ,  Andrew E. Page ,  David S. Alburty

IPC: B01L3/00

CPC classification number: B01L3/505

Abstract: Devices, systems, and methods are disclosed which relate to using a use large area surface sampler with invertible bag for collection of biological and non-biological particles prior to subsequent analysis. The large area surface sampler with invertible bag uses an inverted bag with bonded sampling material to first serve as a sampling device followed by the bag being turned right side out and the captured particles being extracted inside of the bag. The device includes measures for sealing liquid in the sampling material using a protective cup at time of manufacture. This enables users to simply remove the protective cup and perform wet surface sampling prior to turning the bag right side out and removing captured particles from the sampling material with repeated compressions. The described device, systems and methods allow users to capture and elute surface samples for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required.

公开(公告)号：US20180304176A1

公开(公告)日：2018-10-25

申请号：US15960483

申请日：2018-04-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  G01N33/14 ,  C12H1/18 ,  A23L5/20

CPC classification number: B01D19/0073 ,  A23L5/21 ,  A23V2002/00 ,  C12H1/18 ,  G01N1/4055 ,  G01N1/42 ,  G01N33/146

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US20170153164A1

公开(公告)日：2017-06-01

申请号：US15431655

申请日：2017-02-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/10 ,  G01N1/14 ,  G01N1/40

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

公开(公告)号：US09574977B2

公开(公告)日：2017-02-21

申请号：US14191205

申请日：2014-02-26

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/34 ,  G01N1/40

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 一次性吸头包括用于吸取样品并连接到浓缩单元的流体端口。