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    Boron-Containing Diacylhydrazines
    21.
    发明申请
    Boron-Containing Diacylhydrazines 有权
    含硼二酰基肼

    公开(公告)号：US20140274954A1

    公开(公告)日：2014-09-18

    申请号：US14212526

    申请日：2014-03-14

    Applicant: Intrexon Corporation

    Inventor： Sheela K. CHELLAPPAN ,  Robert E. Hormann ,  Inna Shulman

    IPC: C07F5/04 ,  C07F5/02

    CPC classification number: C07F5/025 ,  C07F5/027 ,  C07F5/04 ,  C07F7/0803

    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

    Abstract translation: 本公开提供了具有式I的含硼二酰基肼及其药学上可接受的盐和溶剂化物，其中R1，R2，R3，R4和R5如说明书所述定义。 本公开还提供了含硼二酰肼的用途是基于蜕皮激素受体的诱导型基因表达系统。 因此，本公开对于诸如基因治疗，疾病治疗，蛋白质和抗体的大规模生产，基于细胞的筛选测定，功能基因组学，蛋白质组学，代谢组学和调控转基因生物中的性状等应用是有用的，其中控制 基因表达水平是理想的。

    Biological Conversion of Multi-Carbon Compounds from Methane
    22.
    发明申请
    Biological Conversion of Multi-Carbon Compounds from Methane 有权
    多碳化合物从甲烷的生物转化

    公开(公告)号：US20140273128A1

    公开(公告)日：2014-09-18

    申请号：US14206835

    申请日：2014-03-12

    Applicant: Intrexon Corporation

    Inventor： William J. COLEMAN ,  Genevieve M. VIDANES ,  Guillaume COTTAREL ,  Sheela MULEY ,  Roy KAMIMURA ,  Akbar F. JAVAN ,  Jianping SUN ,  Eli S. GROBAN

    IPC: C12P7/16 ,  C12N15/74

    CPC classification number: C12P7/16 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y202/01006 ,  C12Y203/03006 ,  C12Y401/01072 ,  C12Y402/01009 ,  C12Y402/01033 ,  C12Y403/01019 ,  Y02E50/10

    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

    Abstract translation: 多碳化合物如乙醇，正丁醇，仲丁醇，异丁醇，叔丁醇，脂肪（或脂肪族长链）醇，脂肪酸甲酯，2,3-丁二醇等是重要的工业商品化学品 具有多种应用。 本发明提供代谢工程的宿主微生物，其代谢甲烷（CH4）作为其唯一的碳源，以生产用于燃料（例如生物燃料，生物柴油）和生物基化学品的多碳化合物。 此外，使用本发明的代谢工程的宿主微生物（其利用甲烷作为唯一碳源）减轻了目前的行业实践和从石油或石油衍生的原料生产多碳化合物的方法，并且改善了大部分正在进行的耗尽 目前正在转用生物燃料原料的可耕食源“农田”，从而改善未来生物燃料，生物柴油和生物基化学成分的环境足迹。

    mTOR Ligands and Polynucleotides Encoding mTOR Ligands
    23.
    发明申请
    mTOR Ligands and Polynucleotides Encoding mTOR Ligands 审中-公开
    mTOR配体和编码mTOR配体的多核苷酸

    公开(公告)号：US20140178931A1

    公开(公告)日：2014-06-26

    申请号：US14187930

    申请日：2014-02-24

    Applicant: Intrexon Corporation

    Inventor： Thomas David REED ,  Amy H. Aztel

    IPC: C07K14/47

    CPC classification number: A61K38/16 ,  A61K48/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4703 ,  C07K2319/02 ,  C07K2319/41 ,  C12N1/20 ,  C12N15/10 ,  C12N15/62

    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

    Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节mTOR活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。

    Microorganisms and Methods for the Fermentation of Cannabinoids
    24.
    发明申请
    Microorganisms and Methods for the Fermentation of Cannabinoids 有权

    公开(公告)号：US20210348137A1

    公开(公告)日：2021-11-11

    申请号：US16753983

    申请日：2018-10-04

    Applicant: Intrexon Corporation

    Inventor： Bela Krisztian Szamecz ,  Szilvia Varszegi ,  Attila Nemeth ,  Lorand Szabo ,  Abhunav Kumar

    IPC: C12N9/10 ,  C12P7/42 ,  A61K31/352 ,  C12N15/81 ,  C12P17/06

    Abstract: Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.

    BORON-CONTAINING DIACYLHYDRAZINES
    26.
    发明申请
    BORON-CONTAINING DIACYLHYDRAZINES 审中-公开

    公开(公告)号：US20200157122A1

    公开(公告)日：2020-05-21

    申请号：US16580343

    申请日：2019-09-24

    Applicant: Intrexon Corporation

    Inventor： Sheela K. Chellappan ,  Robert E. Hormann ,  Inna Shulman

    IPC: C07F5/02 ,  C07F5/04 ,  C07F7/08

    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

    Boron-containing diacylhydrazine compounds
    27.
    发明授权
    Boron-containing diacylhydrazine compounds 有权

    公开(公告)号：US10570158B2

    公开(公告)日：2020-02-25

    申请号：US15915415

    申请日：2018-03-08

    Applicant: Intrexon Corporation

    Inventor： Ray A. James ,  Sheela K. Chellappan ,  Robert E. Hormann

    IPC: A61K31/69 ,  C07F5/02 ,  C07D263/06 ,  A01N37/28 ,  A01N55/08 ,  A61K45/06

    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

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