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公开(公告)号：US07816363B2
公开(公告)日：2010-10-19
申请号：US10506998
申请日：2003-03-11
申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Marc Gustaaf Celine Verdonck , Alexey Borisovich Dyatkin
发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Marc Gustaaf Celine Verdonck , Alexey Borisovich Dyatkin
IPC分类号： C07D239/00 , C07D239/02 , C07D401/04 , C07D239/42 , A01N43/54
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式（I）化合物。 其制剂，含有它们的组合物及其作为药物的用途。
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22.发明授权Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors 有权法呢基转移酶抑制喹啉和喹唑啉衍生物作为法呢基转移酶抑制剂公开(公告)号：US07053105B2
公开(公告)日：2006-05-30
申请号：US10381363
申请日：2001-09-18
IPC分类号： A61K31/47 , C07D215/38 , C07D215/20
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention comprises the novel compounds of formula (I) wherein r, s, t, Y1—Y2, R1, R2, R3, R4, R5 and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中r，s，t，Y 1，...，R 2，R 1， SUP> 2，R 3，R 4，R 5和R 7具有定义的含义 ，具有法呢基转移酶抑制活性; 其制剂，含有它们的组合物及其作为药物的用途。
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23.发明申请公开(公告)号：US20130324568A1
公开(公告)日：2013-12-05
申请号：US13962523
申请日：2013-08-08
申请人： Marc Gustaaf Celine VERDONCK , Partick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine VERDONCK , Partick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： C07D401/14 , C07D409/14 , C07D491/056 , C07D405/14
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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公开(公告)号：US08557825B2
公开(公告)日：2013-10-15
申请号：US13325330
申请日：2011-12-14
申请人： Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
发明人： Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
IPC分类号： A61K31/496 , C07D295/26
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中n，m，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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25.发明授权Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US08524728B2
公开(公告)日：2013-09-03
申请号：US13027793
申请日：2011-02-15
申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： A61K31/506 , C07D401/14
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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26.发明授权公开(公告)号：US08513237B2
公开(公告)日：2013-08-20
申请号：US13425690
申请日：2012-03-21
申请人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/55 , A61K31/506 , A61K31/4545 , A61K31/5377 , C07D211/58 , C07D401/04 , C07D401/14 , C07D413/14
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US08299256B2
公开(公告)日：2012-10-30
申请号：US12529142
申请日：2008-03-07
申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号： C07D215/38
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
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28.发明申请SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权取代的亚氨基哌啶或吗啉衍生物作为HISTONE脱乙酰酶的新型抑制剂公开(公告)号：US20120157456A1
公开(公告)日：2012-06-21
申请号：US13302930
申请日：2011-11-22
申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/04 , C07D401/04 , A61K31/506
CPC分类号： C07D405/14 , C07D401/04
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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29.发明授权Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US08193205B2
公开(公告)日：2012-06-05
申请号：US11572563
申请日：2005-07-25
申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号： C07D401/14 , C07D409/14 , A61K31/506
CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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30.发明申请公开(公告)号：US20120088754A1
公开(公告)日：2012-04-12
申请号：US13325330
申请日：2011-12-14
申请人： Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
发明人： Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
IPC分类号： A61K31/551 , C07D295/26 , A61K31/495 , C07D403/12 , A61K31/496 , C07D403/04 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/501 , A61K31/497 , C07D403/14 , C07D409/14 , C07D405/14 , G01N33/573 , A61P35/00 , A61P17/06 , C07D243/08
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中n，m，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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