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1.发明申请SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权取代的亚氨基哌啶或吗啉衍生物作为HISTONE脱乙酰酶的新型抑制剂公开(公告)号：US20120157456A1
公开(公告)日：2012-06-21
申请号：US13302930
申请日：2011-11-22
申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/04 , C07D401/04 , A61K31/506
CPC分类号： C07D405/14 , C07D401/04
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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2.发明授权Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase 有权取代的氨基丙烯基哌啶或吗啉衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US08138198B2
公开(公告)日：2012-03-20
申请号：US11914208
申请日：2006-05-16
申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
IPC分类号： A01N43/54 , A61K31/505 , C07D419/00
CPC分类号： C07D405/14 , C07D401/04
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US08377935B2
公开(公告)日：2013-02-19
申请号：US13302930
申请日：2011-11-22
申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte
IPC分类号： A61K31/50 , A61K31/517 , A61K31/445 , C07D239/00 , C07D241/00 , C07D221/02
CPC分类号： C07D405/14 , C07D401/04
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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公开(公告)号：US08299256B2
公开(公告)日：2012-10-30
申请号：US12529142
申请日：2008-03-07
申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号： C07D215/38
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
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公开(公告)号：US08778966B2
公开(公告)日：2014-07-15
申请号：US13617686
申请日：2012-09-14
申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号： A61K31/04 , C07D413/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D215/227 , C07D417/06
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有 定义含义。
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6.发明申请SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权取代的丙烯酰胆碱衍生物作为HISTONE脱乙酰壳多糖的新型抑制剂公开(公告)号：US20110237585A1
公开(公告)日：2011-09-29
申请号：US13048826
申请日：2011-03-15
申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/496 , C07D403/14 , C07D413/14 , A61P35/00 , A61P17/06
CPC分类号： C07D239/42 , C07D239/54 , C07D403/12
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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7.发明授权Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase 有权取代的丙烯基哌嗪衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US07947830B2
公开(公告)日：2011-05-24
申请号：US11626215
申请日：2007-01-23
申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
IPC分类号： C07D417/00 , C07D413/00 , C07D403/00
CPC分类号： C07D239/42 , C07D239/54 , C07D403/12
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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8.发明授权公开(公告)号：US07888360B2
公开(公告)日：2011-02-15
申请号：US12160156
申请日：2007-01-16
申请人： Patrick René Angibaud , Sven Franciscus Anna Van Brandt , Laurence Françoise Bernadette Marconnet-Decrane , Bruno Roux
发明人： Patrick René Angibaud , Sven Franciscus Anna Van Brandt , Laurence Françoise Bernadette Marconnet-Decrane , Bruno Roux
IPC分类号： C07D239/42 , C07D409/12 , C07D405/14 , C07D403/12 , A61K31/506
CPC分类号： C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括具有组蛋白脱乙酰酶抑制酶活性的式（I）的新化合物，其中R 1，R 2，R 3，X，Y和Z具有定义的含义; 其制剂，含有它们的组合物及其作为药物的用途。
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9.发明授权公开(公告)号：US08114876B2
公开(公告)日：2012-02-14
申请号：US12160124
申请日：2007-01-16
申请人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud
发明人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud
IPC分类号： C07D239/42 , C07D403/12 , A61K31/506
CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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10.发明授权公开(公告)号：US08664223B2
公开(公告)日：2014-03-04
申请号：US13347338
申请日：2012-01-10
申请人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud
发明人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud
IPC分类号： C07D401/04 , A61K31/444
CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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