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公开(公告)号：US20110245905A1
公开(公告)日：2011-10-06
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译： 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。
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公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译： 包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。 在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。 每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。 在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。 所述至少两个生物浸渍金属区域彼此电接触。 生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。
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公开(公告)号：US20090324684A1
公开(公告)日：2009-12-31
申请号：US12489996
申请日：2009-06-23
CPC分类号： A61L31/022 , A61L31/08
摘要： According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.
摘要翻译： 根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。
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