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公开(公告)号：US20120095548A1
公开(公告)日：2012-04-19
申请号：US13238234
申请日：2011-09-21
CPC分类号： A61L31/022 , A61L27/04 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/00
摘要： A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.
摘要翻译： 医疗植入物包括金属基底，连接层，以及覆盖连接层的外表面的至少第一层。 粘结层结合到金属基底表面的至少一部分上。 连接层包括镁或镁基合金。 连接层可以具有包括树枝状晶粒的外表面。 连接层可以具有由孔，突出的颗粒结构和/或突出的颗粒限定的粗糙的外表面。 在医疗装置上制造粘结层的方法包括将镁或镁基合金施加到医疗装置上并冷却镁或镁基合金以产生粗糙的外表面。
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公开(公告)号：US08956403B2
公开(公告)日：2015-02-17
申请号：US13238234
申请日：2011-09-21
CPC分类号： A61L31/022 , A61L27/04 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/00
摘要： A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.
摘要翻译： 医疗植入物包括金属基底，连接层，以及覆盖连接层的外表面的至少第一层。 粘结层结合到金属基底表面的至少一部分上。 连接层包括镁或镁基合金。 连接层可以具有包括树枝状晶粒的外表面。 连接层可以具有由孔，突出的颗粒结构和/或突出的颗粒限定的粗糙的外表面。 在医疗装置上制造粘结层的方法包括将镁或镁基合金施加到医疗装置上并冷却镁或镁基合金以产生粗糙的外表面。
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公开(公告)号：US08834560B2
公开(公告)日：2014-09-16
申请号：US13051496
申请日：2011-03-18
申请人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
发明人： Jan Weber , Liliana Atanasoska , James Lee Shippy, III , Torsten Scheuermann , Daniel J. Gregorich , Michael P. Meyer
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译： 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。
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公开(公告)号：US20110301574A1
公开(公告)日：2011-12-08
申请号：US13210158
申请日：2011-08-15
IPC分类号： A61M25/00
CPC分类号： A61M25/0051 , A61B1/00078 , A61M25/0045 , A61M25/0053 , A61M25/0054 , A61M25/0097 , A61M2025/0046 , A61M2025/0058 , A61M2025/0063 , A61M2025/0065
摘要： Medical devices such as catheters can include structure or provision that permit a physician or other health care professional to adjust the stiffness of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译： 诸如导管的医疗装置可以包括允许医师或其他保健专业人员调节医疗装置的至少一部分的刚度的结构或规定。 在一些情况下，可以在将医疗装置插入病人之前调整医疗装置。 在一些情况下，医疗装置可在患者使用期间进行调整。
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公开(公告)号：US07998132B2
公开(公告)日：2011-08-16
申请号：US11218857
申请日：2005-09-02
IPC分类号： A61M25/00
CPC分类号： A61M25/0051 , A61B1/00078 , A61M25/0045 , A61M25/0053 , A61M25/0054 , A61M25/0097 , A61M2025/0046 , A61M2025/0058 , A61M2025/0063 , A61M2025/0065
摘要： Medical devices such as catheters can include structure or provision that permit a physician or other health care professional to adjust the stiffness of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译： 诸如导管的医疗装置可以包括允许医师或其他保健专业人员调节医疗装置的至少一部分的刚度的结构或规定。 在一些情况下，可以在将医疗装置插入病人之前调整医疗装置。 在一些情况下，医疗装置可在患者使用期间进行调整。
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公开(公告)号：US20110009942A1
公开(公告)日：2011-01-13
申请号：US12709258
申请日：2010-02-19
IPC分类号： A61F2/82
CPC分类号： A61M25/104 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2250/0029 , A61M25/0051 , A61M25/0052 , A61M25/0053 , A61M25/0054 , A61M25/1011 , A61M2025/0183 , A61M2025/1056
摘要： Balloon catheters and stent delivery systems including bifurcated stent delivery systems are disclosed. An example bifurcated stent delivery system may include an elongate shaft including a proximal section, a midshaft section, and a distal section. The proximal section may include a tubular member having a plurality of slots formed therein. The slots may be arranged in one or more sections having differing slot densities. The midshaft section may include a guidewire port in fluid communication with a guidewire lumen formed in the shaft. A main branch balloon may be coupled to the shaft. A side branch balloon may be disposed adjacent to the main branch balloon. A stent may be disposed on the main branch balloon and on the side branch balloon.
摘要翻译： 公开了包括分叉支架输送系统的球囊导管和支架输送系统。 示例性分叉支架输送系统可以包括细长轴，其包括近端部分，中间部分和远端部分。 近端部分可以包括其中形成有多个狭槽的管状构件。 槽可以布置在具有不同槽密度的一个或多个部分中。 中轴部分可以包括与形成在轴中的导丝管腔流体连通的导丝端口。 主分支气囊可以联接到轴。 侧分支气囊可以邻近主分支气囊设置。 支架可以设置在主分支气囊和侧支气囊上。
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公开(公告)号：US20080215136A1
公开(公告)日：2008-09-04
申请号：US11953969
申请日：2007-12-11
申请人： Daniel J. Gregorich , Mike Meyer
发明人： Daniel J. Gregorich , Mike Meyer
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/45 , A61L2300/602
摘要： The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device.
摘要翻译： 本发明涉及可用于将两种或更多种治疗剂以不同速率递送到患者的身体组织的医疗装置，例如血管内支架，以及制造和使用该医疗装置的方法。 医疗装置包括具有多个孔的基底和/或涂层，分散在所述孔中是多个第一和第二治疗剂，其中所述第一治疗剂与第一物质的一个或多个分子结合 和第二治疗剂，其结合到第二材料的一个或多个分子，使得当使用医疗器械（例如，植入体腔诸如血管）时，释放接合的第一治疗剂 以比从粘合的第二治疗剂从医疗装置释放的速度慢的速度从医疗装置开始。
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公开(公告)号：US06911016B2
公开(公告)日：2005-06-28
申请号：US09925881
申请日：2001-08-06
申请人： Brian K. Balzum , Anthony C. Vrba , Brice L. Shireman , Peter Skujins , Kenneth M. Merdan , Daniel J. Gregorich , Pu Zhou
发明人： Brian K. Balzum , Anthony C. Vrba , Brice L. Shireman , Peter Skujins , Kenneth M. Merdan , Daniel J. Gregorich , Pu Zhou
CPC分类号： A61M25/0905 , A61M2025/09083
摘要： Devices and methods for coupling guidewire system components are disclosed. A guidewire system includes a first wire having a first end and a second wire having a second end which may be selectively coupled to the first end of the first wire. Such guidewire systems are useful as guidewire extension systems.
摘要翻译： 公开了用于联接导丝系统部件的装置和方法。 导丝系统包括具有第一端的第一线和具有第二端的第二线，第二端可选择性地联接到第一线的第一端。 这种导丝系统可用作导丝延伸系统。
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公开(公告)号：US09011511B2
公开(公告)日：2015-04-21
申请号：US12709258
申请日：2010-02-19
CPC分类号： A61M25/104 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2250/0029 , A61M25/0051 , A61M25/0052 , A61M25/0053 , A61M25/0054 , A61M25/1011 , A61M2025/0183 , A61M2025/1056
摘要： Balloon catheters and stent delivery systems including bifurcated stent delivery systems are disclosed. An example bifurcated stent delivery system may include an elongate shaft including a proximal section, a midshaft section, and a distal section. The proximal section may include a tubular member having a plurality of slots formed therein. The slots may be arranged in one or more sections having differing slot densities. The midshaft section may include a guidewire port in fluid communication with a guidewire lumen formed in the shaft. A main branch balloon may be coupled to the shaft. A side branch balloon may be disposed adjacent to the main branch balloon. A stent may be disposed on the main branch balloon and on the side branch balloon.
摘要翻译： 公开了包括分叉支架输送系统的球囊导管和支架输送系统。 示例性分叉支架输送系统可以包括细长轴，其包括近端部分，中间部分和远端部分。 近端部分可以包括其中形成有多个狭槽的管状构件。 槽可以布置在具有不同槽密度的一个或多个部分中。 中轴部分可以包括与形成在轴中的导丝管腔流体连通的导丝端口。 主分支气囊可以联接到轴。 侧分支气囊可以邻近主分支气囊设置。 支架可以设置在主分支气囊和侧支气囊上。
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公开(公告)号：US08435280B2
公开(公告)日：2013-05-07
申请号：US11095004
申请日：2005-03-31
申请人： Daniel J. Gregorich
发明人： Daniel J. Gregorich
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2250/0036
摘要： Medical devices, such as endoprostheses, are disclosed. In some embodiments, an endoprosthesis includes a circumferentially-oriented band including two curved portions and a first portion connecting the two curved portions, the first portion having a first width and at least one curved portion having a second width; and a connector extending from the band; wherein the second width is greater than the first width.
摘要翻译： 公开了医疗装置，例如内用假体。 在一些实施例中，内假体包括包括两个弯曲部分的周向定向带和连接两个弯曲部分的第一部分，第一部分具有第一宽度和至少一个具有第二宽度的弯曲部分; 以及从所述带延伸的连接器; 其中所述第二宽度大于所述第一宽度。
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