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公开(公告)号：US08690824B2
公开(公告)日：2014-04-08
申请号：US13441664
申请日：2012-04-06
CPC分类号： A61M25/1002 , A61F2/958 , A61L29/16 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1088
摘要： This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
摘要翻译： 本公开涉及医疗装置和相关方法。 在一些实施例中，所述方法包括将材料施加到球囊，然后从气囊的一个或多个区域移除材料。
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公开(公告)号：US08277833B2
公开(公告)日：2012-10-02
申请号：US12489996
申请日：2009-06-23
CPC分类号： A61L31/022 , A61L31/08
摘要： According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.
摘要翻译： 根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。
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公开(公告)号：US08153181B2
公开(公告)日：2012-04-10
申请号：US11599052
申请日：2006-11-14
CPC分类号： A61M25/1002 , A61F2/958 , A61L29/16 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1088
摘要： This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
摘要翻译： 本公开涉及医疗装置和相关方法。 在一些实施例中，所述方法包括将材料施加到球囊，然后从气囊的一个或多个区域移除材料。
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公开(公告)号：US20100222873A1
公开(公告)日：2010-09-02
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。
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公开(公告)号：US08771343B2
公开(公告)日：2014-07-08
申请号：US11763770
申请日：2007-06-15
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2002/30322 , A61F2250/0026 , A61F2250/0056 , A61F2310/00616 , A61F2310/0097 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/00 , B05D1/32
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.
摘要翻译： 描述医疗装置，例如内用假体，以及制造装置的方法。 在一些实施例中，医疗装置包括互连带的主体和形成细长管状结构的连接器，其具有内管腔壁表面和外侧腔壁表面，并限定中央腔或通道。 形成穿过细长管状结构的横向通道的带和连接件的内腔壁表面和侧壁表面可以承受亲水材料的涂层，并且管状结构的外侧壁面可承受疏水材料的涂层。
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公开(公告)号：US08417356B2
公开(公告)日：2013-04-09
申请号：US13009655
申请日：2011-01-19
申请人： Jeannette C. Polkinghorne , Robert W. Warner , James Q. Feng , James Lee Shippy, III , Ljiljana Liliana Atanasoska
发明人： Jeannette C. Polkinghorne , Robert W. Warner , James Q. Feng , James Lee Shippy, III , Ljiljana Liliana Atanasoska
IPC分类号： A61N1/05
CPC分类号： A61N1/0565
摘要： A biomimetic electrode material including a fibrous matrix including a conductive polymer and an ion conducting polymeric material is described. The biomimetic electrode material may be used in a number of body-implantable applications including cardiac and neuro-stimulation applications. The biomimetic electrode material can be formed using electrospinning and other related processes. The biomimetic electrode may facilitate efficient charge transport from ionically conductive tissue to the electronically conductive electrode, and may induce surrounding tissue to attach or interface directly to the implanted device, increasing the biocompatibility of the device.
摘要翻译： 描述了包括包含导电聚合物和离子导电聚合材料的纤维基质的仿生电极材料。 仿生电极材料可用于许多可植入人体的应用，包括心脏和神经刺激应用。 仿生电极材料可以使用静电纺丝和其它相关工艺形成。 仿生电极可以促进从离子导电组织到电子导电电极的有效电荷输送，并且可以诱导周围组织附着或直接连接到植入装置，增加装置的生物相容性。
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8.发明授权Medical devices employing conductive polymers for delivery of therapeutic agents 有权使用导电聚合物递送治疗剂的医疗装置公开(公告)号：US08275455B2
公开(公告)日：2012-09-25
申请号：US12487203
申请日：2009-06-18
IPC分类号： A61N1/30
CPC分类号： A61M25/1029 , A61F2002/0081 , A61F2250/0068 , A61K9/0009 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/52 , A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61M25/10 , A61M25/104 , A61M2025/0057 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093
摘要： In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.
摘要翻译： 根据一个方面，本发明涉及包括至少一个贮存器，设置在储存器内的含治疗剂的区域和包含导电聚合物的电极的医疗装置。 本发明的装置被配置成使得治疗剂从贮存器释放的速率随着导电聚合物的氧化态的变化而变化。
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公开(公告)号：US20090118815A1
公开(公告)日：2009-05-07
申请号：US11934463
申请日：2007-11-02
IPC分类号： A61F2/06
CPC分类号： B05D1/12 , A61L31/08 , A61L31/146 , C23C24/04
摘要： Endoprosthesis includes coatings of selected porosity formed of particulates of ceramics, metals, drugs and/or polymers.
摘要翻译： 内置假体包括由陶瓷，金属，药物和/或聚合物颗粒形成的选定孔隙的涂层。
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10.发明申请STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT 审中-公开治疗药物的尿素和尿素释放的差异时间公开(公告)号：US20090062910A1
公开(公告)日：2009-03-05
申请号：US11940503
申请日：2007-11-15
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91575 , A61F2230/0013 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08
摘要： The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medical device. More particularly, the invention is directed to a stent having a tubular sidewall with a first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer.
摘要翻译： 本发明总体上涉及可用于将治疗剂递送到患者的身体组织的医疗装置以及用于制造这种医疗装置的方法。 更具体地说，本发明涉及一种具有管状侧壁的支架，该管状侧壁至少在腔表面和/或外侧表面上具有第一涂层组合物，第二涂层组合物设置在第一涂层组合物的至少一部分上， 扩散性生物降解聚合物。
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