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    Implantable medical devices having adjustable pore volume and methods for making the same
    1.
    发明授权
    Implantable medical devices having adjustable pore volume and methods for making the same 有权
    具有可调孔容积的可植入医疗器械及其制造方法

    公开(公告)号：US07909864B2

    公开(公告)日：2011-03-22

    申请号：US12166377

    申请日：2008-07-02

    Applicant: Min-Shyan Sheu ,  Steve Walak ,  Yixin Xu

    Inventor： Min-Shyan Sheu ,  Steve Walak ,  Yixin Xu

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61L31/14 ,  A61L31/146 ,  A61L2300/60 ,  A61L2300/608 ,  A61L2420/08

    Abstract: The present invention is directed to implantable medical devices which may be used for controllably releasing a therapeutic agent within a patient and methods for making the same. These medical devices may include porous coatings, which may be polymer-free, located on an outer surface or abluminal surface of the medical device. The medical device may be a stent. The pores of the porous coating may be expandable to facilitate loading of the therapeutic agent. The medical device may be triggerable upon implantation of the medical device such that the volume of the voids shrinks to eject the therapeutic agent. The voids may be slots in the stent. Expandable materials or structures may be positioned in the voids to expand upon implantation and eject the therapeutic agent.

    Abstract translation: 本发明涉及可用于可控地释放患者内的治疗剂的可植入医疗装置及其制造方法。 这些医疗装置可以包括位于医疗装置的外表面或外表面上的多孔涂层，其可以是无聚合物的。 医疗装置可以是支架。 多孔涂层的孔可以是可膨胀的，以便于治疗剂的加载。 医疗装置可以在植入医疗装置时触发，使得空隙的体积收缩以喷射治疗剂。 空隙可以是支架中的狭槽。 可膨胀材料或结构可以位于空隙中，以在植入时膨胀并喷射治疗剂。

    DRUG-LOADED MEDICAL DEVICES AND METHODS FOR MANUFACTURING DRUG-LOADED MEDICAL DEVICES
    2.
    发明申请
    DRUG-LOADED MEDICAL DEVICES AND METHODS FOR MANUFACTURING DRUG-LOADED MEDICAL DEVICES 审中-公开
    药物装载医疗装置及其制造装载药物的方法

    公开(公告)号：US20090274740A1

    公开(公告)日：2009-11-05

    申请号：US12433341

    申请日：2009-04-30

    Applicant: Michael Kuehling ,  Yixin XU

    Inventor： Michael Kuehling ,  Yixin XU

    IPC: A61K9/00 ,  B05D1/00 ,  A61P43/00

    CPC classification number: A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/606

    Abstract: Drug-loaded medical devices such as stents and methods for manufacturing them are provided. In certain embodiments, the therapeutic agent is loaded only in or on areas of the medical device that do not undergo substantial deformation during expansion. The medical device may be provided with reservoirs in or on the first portions of the medical device that do not undergo substantial deformation during expansion, and the therapeutic agent may be loaded in these reservoirs. The reservoirs may be covered with a porous coating which may be a non-polymeric coating. In other embodiments, a non-polymeric coating is provided in a discontinuous manner in or on the medical device. A method includes the steps of providing a transfer member that includes a translucent substrate and a layer of transfer material such as a film or foil; attaching reservoirs to the transfer material; positioning the transfer member with the reservoirs adjacent a medical device, such as a stent, with the reservoirs facing the medical device; and directing a laser beam at the transfer member such that the laser beam passes through the translucent substrate to vaporize a portion of the transfer material, creating a pocket of trapped gas between the translucent substrate and reservoir, thereby forcing the reservoir from the transfer member to the medical device. The reservoirs may be formed of a non-polymeric material.

    Abstract translation: 提供诸如支架的药物装载的医疗装置及其制造方法。 在某些实施方案中，治疗剂仅在扩张期间不经历基本变形的医疗装置的区域中或其上加载。 医疗装置可以在医疗装置的第一部分中或其上设置有在膨胀期间不经历实质变形的第一部分上的储存器，并且治疗剂可以装载在这些储存器中。 储存器可以覆盖有可以是非聚合物涂层的多孔涂层。 在其它实施方案中，在医疗装置中或其上以不连续的方式提供非聚合物涂层。 一种方法包括提供包括透光性基板和转印材料层例如膜或箔的转印部件的步骤; 将储存器附接到转印材料上; 将所述转移构件与所述储存器邻近医疗装置（例如支架）定位，所述储存器面向所述医疗装置; 并且将激光束引导在转印部件处，使得激光束通过透光性基板以蒸发转印材料的一部分，从而在透光性基板和储存器之间形成捕获气体的袋状物，从而迫使储存器从转印部件 医疗器械。 储存器可以由非聚合材料形成。

    METHODS AND SYSTEMS FOR APPLYING THERAPEUTIC AGENT TO A MEDICAL DEVICE
    4.
    发明申请
    METHODS AND SYSTEMS FOR APPLYING THERAPEUTIC AGENT TO A MEDICAL DEVICE 审中-公开
    将治疗药物应用于医疗器械的方法和系统

    公开(公告)号：US20080251391A1

    公开(公告)日：2008-10-16

    申请号：US12100581

    申请日：2008-04-10

    Applicant: John Benco ,  Yixin Xu

    Inventor： John Benco ,  Yixin Xu

    IPC: C25D9/02 ,  C25D17/00

    CPC classification number: C25D7/00 ,  A61F2/82 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/80 ,  C25D9/02 ,  C25D13/04

    Abstract: In methods and systems for applying a coating to a medical device, such as a coating comprising a therapeutic agent, electrons may be transferred from an electrode to ionize a therapeutic agent dissolved in an electrolytic solution. The ionized therapeutic agent may then be electrochemically delivered to the medical device. The medical device may be a stent, which may have a porous surface.

    Abstract translation: 在用于将涂层施加到诸如包含治疗剂的涂层的医疗装置的方法和系统中，电子可以从电极转移以电离溶解在电解溶液中的治疗剂。 然后可将电离治疗剂电化学递送至医疗装置。 医疗装置可以是可以具有多孔表面的支架。

    Endoprosthesis with Selective Drug Coatings
    7.
    发明申请
    Endoprosthesis with Selective Drug Coatings 审中-公开
    选择性药物涂层内置假体

    公开(公告)号：US20100274352A1

    公开(公告)日：2010-10-28

    申请号：US12429392

    申请日：2009-04-24

    Applicant: Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    Inventor： Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    IPC: A61F2/06

    CPC classification number: A61L31/10 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/61

    Abstract: An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.

    Abstract translation: 诸如冠状动脉支架的内用假体包括管腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和腔内表面，其至少一部分被第二涂层覆盖，所述第二涂层包括第二药物 。 第一种药物基于第一种涂层具有第一洗脱分布，而第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。 还提供了制备其的方法。

    Medical Devices Having Porous Component For Controlled Diffusion
    9.
    发明申请
    Medical Devices Having Porous Component For Controlled Diffusion 有权
    具有控制扩散的多孔成分的医疗器械

    公开(公告)号：US20090157166A1

    公开(公告)日：2009-06-18

    申请号：US12333909

    申请日：2008-12-12

    Applicant: Anurag Singhal ,  Robert A. Herrmann ,  Yixin Xu ,  Young-Ho Song

    Inventor： Anurag Singhal ,  Robert A. Herrmann ,  Yixin Xu ,  Young-Ho Song

    IPC: A61F2/06

    CPC classification number: A61L31/14 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L29/14 ,  A61L29/146 ,  A61L29/16 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/602

    Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.

    Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）具有一个或多个凹陷的基底，其含有至少一种治疗剂，和（b）设置在基底上的多孔膜， 一个或多个凹陷，其调节化学物质在含治疗剂的凹陷和装置的外部之间的运输。 基板和多孔膜由各自具有不同热膨胀系数的不同材料形成。 此外，衬底和多孔膜中的一个至少部分地围绕另一个。 本发明的其它方面涉及制造这种医疗装置的方法，以及使用这种医疗装置的治疗方法。

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