Abstract:
The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
Abstract:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract:
Individual records of a data set include data and semantic information to describe the data. The records in the data set are encoded to generate an encoded data set using a compression function which is determined from semantic information that is common to multiple records of the data set. Multiple records of the encoded data set include the data without the common semantic information. The encoded data set is transmitted, or otherwise communicated, to a destination device along with an expansion function that includes the semantic information that is common to the multiple records of the data set. The destination device expands the encoded data set with the expansion function such that the multiple records of the encoded data set are expanded to include the common semantic information.
Abstract:
Methods providing clients with a full contextual metadata experience. Metadata include multiple forms of property data, or information, relating to media accessed by a media player, such as a CD in a CD-ROM drive of a computer. Metadata is transferred from a server to a client. Identification parameters associated with the accessed media file are submitted by the client to a server, and property data is retrieved and forwarded to the client. The metadata provides the user with integrated, contemporaneous property data directly related to the media file being played, providing automatic, integrated access to data from multiple databases, simply by accessing a related media file through a media player, without further direction from the user.
Abstract:
The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.