公开(公告)号：US06375960B1

公开(公告)日：2002-04-23

申请号：US09474074

申请日：1999-12-29

Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

IPC: A61K600

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/937 ,  Y10S514/938

Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to 45° C. and which is selected from the group including ethoxylated fatty ethers and ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic, opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

Abstract translation: 本发明提供一种纳米乳液，其包括：分散在水相中的油相; 和至少一种在小于或等于45℃的温度下为固体的表面活性剂，并且其选自乙氧基化脂肪醚和乙氧基化脂肪酯，以及它们的混合物; 其中油相包括数均分子量小于100nm的油球;其中油相包含至少一种分子量大于400的油; 并且其中油相与表面活性剂的重量比为2至10.本发明还提供了制备纳米乳液的方法及其使用方法。 乳液在储存时理想的透明和稳定。 它理想地含有大量的油，同时保持良好的透明度和良好的化妆品性能。 纳米乳液在组合物中特别有用，包​​括局部，药物，化妆品，眼科，眼科学。 该组合物在对皮肤，毛发，头皮，粘膜和眼睛的应用中也特别有用。

公开(公告)号：US6022559A

公开(公告)日：2000-02-08

申请号：US978377

申请日：1997-11-25

Applicant: Jean-Thierry Simonnet

Inventor： Jean-Thierry Simonnet

IPC: A61K9/127 ,  A61K8/00 ,  A61K8/14 ,  A61K8/37 ,  A61K8/39 ,  A61K8/72 ,  A61K8/73 ,  A61K8/81 ,  A61K8/85 ,  A61K8/87 ,  A61K8/98 ,  A61K47/30 ,  A61Q5/00 ,  A61Q19/08 ,  A61K6/00 ,  A61K7/06

CPC classification number: A61Q5/00 ,  A61K8/14 ,  A61K8/85 ,  A61Q19/08

Abstract: A dispersion, in an aqueous medium, of dehydration-resistant vesicles containing a lipid phase and an encapsulated aqueous phase. The dispersion additionally contains, either in the aqueous medium or in the encapsulated aqueous phase or in both, at least one polymer, in the form of particles, which has a glass transition temperature Tg, in the presence or absence of a plasticizing agent, of lower than 70.degree. C. at 0% relative humidity. The dispersion can be used in the cosmetic or pharmaceutical fields for topical application for the care and/or makeup of the skin and for care of the scalp and/or hair.

Abstract translation: 在含水介质中的含有脂质相和封装水相的耐脱水小泡的分散体。 该分散体在含水介质或包封的水相中或在两者中还含有颗粒形式的至少一种聚合物，其在存在或不存在增塑剂的情况下具有玻璃化转变温度Tg， 在0％相对湿度下低于70℃。 分散体可用于化妆品或药物领域，用于局部应用于皮肤护理和/或化妆以及护理头皮和/或头发。

公开(公告)号：US5679691A

公开(公告)日：1997-10-21

申请号：US597101

申请日：1996-02-06

Applicant: Alain Ribier ,  Quang Lan Nguyen ,  Jean-Thierry Simonnet ,  Boudiaf Boussouira

Inventor： Alain Ribier ,  Quang Lan Nguyen ,  Jean-Thierry Simonnet ,  Boudiaf Boussouira

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/06 ,  A61K8/11 ,  A61K8/14 ,  A61K8/19 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/72 ,  A61K8/73 ,  A61K8/86 ,  A61K8/92 ,  A61K8/97 ,  A61K9/127 ,  A61K31/135 ,  A61K31/15 ,  A61K31/42 ,  A61K31/44 ,  A61K31/445 ,  A61P17/00 ,  A61P17/10 ,  A61P43/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/40 ,  A61K7/42

CPC classification number: B82Y5/00 ,  A61K31/135 ,  A61K31/15 ,  A61K31/42 ,  A61K31/445 ,  A61K8/14 ,  A61K8/4926 ,  A61K9/1272 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S977/778 ,  Y10S977/78 ,  Y10S977/926

Abstract: The invention relates to the use of a spin trap employed as an electron paramagnetic resonance measurement probe, in a cosmetic or dermatological composition for the light-protective, anti-ageing and/or anti-acne treatment of the skin. In particular, this spin trap is encapsulated in lipid vesicles which are capable of diffusing into the deep layers of the skin.

Abstract translation: 本发明涉及在化妆品或皮肤病学组合物中用作电子顺磁共振测量探针的自旋阱，其用于皮肤的光保护性，抗老化和/或抗痤疮治疗。 特别地，该自旋捕获器被包封在能够扩散到皮肤深层的脂质囊泡中。

公开(公告)号：US5601833A

公开(公告)日：1997-02-11

申请号：US366741

申请日：1994-12-30

Applicant: Alain Ribier ,  Jean-Thierry Simonnet ,  Elisabeth Picard ,  Jacqueline Griat

Inventor： Alain Ribier ,  Jean-Thierry Simonnet ,  Elisabeth Picard ,  Jacqueline Griat

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/14 ,  A61K8/25 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/55 ,  A61K8/58 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/68 ,  A61K8/72 ,  A61K8/73 ,  A61K8/88 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61Q17/00 ,  A61Q19/00 ,  A61K9/127

CPC classification number: A61K8/4926 ,  A61K8/14 ,  A61K8/42 ,  A61K8/49 ,  A61K8/673 ,  A61K8/678 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/59

Abstract: Compositions comprising a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from anti-oxygenated-free-radical agents, proteins, sugars, enzymes, vitamins, nucleotides and sequences thereof, trace elements, coenzymes, unsaturated fatty acid-rich phospholipids, silicon derivatives and plant extracts, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from screening agents, anti-oxygenated-free-radical agents, sugars, amino acids, vitamins, ceramides, unsaponifiable products derived from plant oils, and components of sweat, for treating these surface layers, are effective protecting, nourishing and/or firming the skin.

Abstract translation: 包含脂质囊泡的第一分散体的组合物，其能够渗入皮肤的深层并且含有至少一种选自抗氧合自由基剂，蛋白质，糖，酶，维生素，核苷酸和序列的活性剂 微量元素，辅酶，富含不饱和脂肪酸的磷脂，硅衍生物和植物提取物，用于处理这些深层，以及脂质囊泡的第二分散体，其能够渗透到皮肤的表层中并且至少含有 选自筛选剂，抗氧化自由基剂，糖，氨​​基酸，维生素，神经酰胺，来源于植物油的不皂化物和用于处理这些表面层的汗液成分的一种活性剂是有效的保护，滋养和 /或使皮肤紧致。

公开(公告)号：US10555887B2

公开(公告)日：2020-02-11

申请号：US13996179

申请日：2011-12-20

Applicant: Henri Samain ,  Jean-Thierry Simonnet

Inventor： Henri Samain ,  Jean-Thierry Simonnet

IPC: A61K8/73 ,  A61Q19/08 ,  A61K8/81 ,  A61N5/06 ,  A61Q19/00

Abstract: The subject matter of the present invention is a sterile liquid composition dedicated to administration into or through the skin and/or the lips, wherein said composition comprises, in a physiologically acceptable medium, at least one photo-crosslinkable compound, wherein said compound comprises at least one activated photo-dimerizable group having at least one activated double bond and selected from photo-dimerizable groups carrying a stilbazolium function of formula (Ia) or (Ib) and wherein the photo-dimerizable groups carry a styrylazolium function of formula (II), the photo-dimerizable group(s) being carried by a partially or totally hydrolysed poly(vinyl acetate) polymer, a polysaccharide or a polyvinyl alcohol.

公开(公告)号：US10449126B2

公开(公告)日：2019-10-22

申请号：US12637803

申请日：2009-12-15

Applicant: Florence L'Alloret ,  Jean-Thierry Simonnet

Inventor： Florence L'Alloret ,  Jean-Thierry Simonnet

IPC: A61K8/02 ,  A61K8/86 ,  A61K8/46 ,  A61K8/06 ,  A61K8/60 ,  A61Q19/00 ,  A61Q5/00

Abstract: The present invention relates to a composition in the form of an emulsion of the oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and which are dispersed in an aqueous phase, wherein it has a pH ranging from 3 to 5.5 and in that it contains at least one lipophilic surface-active agent with an HLB ranging from 2 to 5, at least one hydrophilic surface-active agent with an HLB ranging from 8 to 12 and at least one amphiphilic compound of ionic nature at a pH ranging from 3 to 5.5.

公开(公告)号：US09168218B2

公开(公告)日：2015-10-27

申请号：US13357923

申请日：2012-01-25

Applicant: Emmanuel Dimotakis ,  Hy Si Bui ,  Jean-Thierry Simonnet ,  Mohamed Kanji

Inventor： Emmanuel Dimotakis ,  Hy Si Bui ,  Jean-Thierry Simonnet ,  Mohamed Kanji

IPC: A61K8/85 ,  A61Q17/04 ,  A61Q1/02 ,  A61Q5/06 ,  A61Q1/10 ,  A61Q19/02 ,  A61Q1/04 ,  A61Q5/02 ,  A61Q5/12

CPC classification number: A61K8/85 ,  A61K2800/434 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/02

Abstract: Disclosed are cosmetic compositions and methods for making up keratinous tissue using the compositions, as well as methods of making the compositions. The compositions contain a photoluminescent polymer (PLP) which is an oligomeric polyester synthesized from a multifunctional monomer and a diol, and which has grafted thereon an amino acid or an amino acid derivative. The compositions achieve a colorizing and/or UV-protectant effect when applied to keratinous tissue.

Abstract translation: 公开了使用该组合物制备角质组织的化妆品组合物和方法，以及制备组合物的方法。 该组合物含有光致发光聚合物（PLP），它是由多官能单体和二醇合成的低聚聚酯，并在其上接枝有氨基酸或氨基酸衍生物。 当施用于角质组织时，组合物获得着色和/或UV-保护作用。

公开(公告)号：US08834903B2

公开(公告)日：2014-09-16

申请号：US10724826

申请日：2003-12-02

Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

IPC: A61K8/02 ,  A61Q5/00 ,  A61K8/60 ,  A61K8/06 ,  A61Q19/00 ,  B82Y5/00 ,  A61Q1/14

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/062 ,  A61K8/60 ,  A61K8/602 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/938

Abstract: A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract translation: 纳米乳液的数均粒径小于100nm的纳米乳液包含在小于或等于45℃的温度下为固体的表面活性剂，该表面活性剂选自脂肪酸的酯 以及脂肪醇和糖的糖和醚，以及至少一种分子量大于400的油，油相量与表面活性剂的重量比为2至10。 纳米乳液可以用于化妆品和皮肤病学应用，特别是用于保湿皮肤和/或粘膜，以及用于治疗头发和在眼科领域中，作为用于治疗眼睛的眼液。

公开(公告)号：US08557227B2

公开(公告)日：2013-10-15

申请号：US13304202

申请日：2011-11-23

Applicant: Jean-Thierry Simonnet ,  Anil Shah ,  Susan Halpern

Inventor： Jean-Thierry Simonnet ,  Anil Shah ,  Susan Halpern

IPC: A61K8/00

CPC classification number: A61K8/37 ,  A61K8/35 ,  A61K8/40 ,  A61Q17/04

Abstract: The disclosure relates to sunscreen compositions having a synergistic combination of ultraviolet light (UV) filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high overall amounts of UV filtering agents, and without requiring the use of oxybenzone. Furthermore, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.

Abstract translation: 本公开涉及具有提供高防晒因子（SPF）的紫外线（UV）过滤剂的协同组合的防晒组合物。 根据本公开的组合物具有高的SPF值，而不需要高量的UV过滤剂，并且不需要使用羟基苯酮。 此外，本公开涉及使用所述组合物从紫外线辐射中保护角质物质如皮肤和毛发的方法。

公开(公告)号：US20130261093A1

公开(公告)日：2013-10-03

申请号：US13434531

申请日：2012-03-29

Applicant: Patricia BRIEVA ,  Angelike GALDI ,  Jean-Thierry SIMONNET ,  Anthony POTIN

Inventor： Patricia BRIEVA ,  Angelike GALDI ,  Jean-Thierry SIMONNET ,  Anthony POTIN

IPC: A61K8/92 ,  A61Q19/00

CPC classification number: A61K8/345 ,  A61K8/062 ,  A61K8/8111 ,  A61K8/894 ,  A61Q19/00

Abstract: A cosmetic composition in the form of an oil-in-water emulsion methods of using and producing cosmetic compositions is provided. The cosmetic composition includes an aqueous phase, an oil phase comprising a water-in-oil emulsifier, and an oil stabilizing component. The water-in-oil emulsifier is at concentration, by weight, of about 0.01% to about 6.0%, based upon weight of the composition. The oil stabilizing component includes one or both of an amphiphilic compound or a surfactant having an HLB of 13 or greater added to the aqueous phase. The oil stabilizing component is at a concentration, by weight, of about 0.01% to about 1.0%, based upon weight of the composition. The oil-in-water emulsion has an increased water load relative to water-in-oil emulsions without having an increased viscosity.

Abstract translation: 提供了一种使用和生产化妆品组合物的水包油乳液方法的化妆品组合物。 化妆品组合物包括水相，包含油包水乳化剂的油相和油稳定组分。 基于组合物的重量，油包水乳化剂的浓度为约0.01％至约6.0％。 油稳定化组分包括两相化合物或HLB为13或更高的表面活性剂中的一种或两种添加到水相中。 基于组合物的重量，油稳定组分的重量浓度为约0.01％至约1.0％。 水包油乳液相对于油包水乳液而言具有增加的水负荷，而不增加粘度。