4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance
    22.
    发明申请
    4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance 有权
    4(1H) - 具有抗疟疾活性的喹诺酮类化合物抗性降低

    公开(公告)号:US20130123258A1

    公开(公告)日:2013-05-16

    申请号:US13661300

    申请日:2012-10-26

    CPC classification number: C07D215/233 C07D215/56 C07D401/04 C07D413/04

    Abstract: Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

    Abstract translation: 提供了有效抑制或消除疟疾寄生虫生命周期中的至少一个阶段的存活力的4(1H) - 喹诺酮衍生物,并且显示降低由靶寄生虫诱导对化合物的抗性的倾向。 特别地,所述化合物可以是苯氧基乙氧基 - 喹诺酮的衍生物,并且包括但不限于7-(2-苯氧基乙氧基)喹啉衍生物。 这些化合物可以自身与至少一种其它衍生化合物或与其它抗疟药化合物一起施用于动物或人类受试者。 治疗组合物可以并配制成减少接受者受试者中疟原虫感染的程度,或者如果在寄生虫接触受试者之前施用,则降低发生或建立疟原虫感染的可能性。 治疗组合物可以配制成提供有效的单次剂量的抗疟药化合物或多个剂量用于一段时间的给药。

    Multiple instance commercial browser website test agent
    23.
    发明授权
    Multiple instance commercial browser website test agent 有权
    多实例商业浏览器网站测试代理

    公开(公告)号:US08407337B2

    公开(公告)日:2013-03-26

    申请号:US12502502

    申请日:2009-07-14

    CPC classification number: H04L67/22 H04L67/02

    Abstract: A website test environment invokes multiple instances of a commercial browser, and captures invocations of browser operations for gathering performance data without interference from other instances or multiple occurrences of the operating system (OS). Commercial browsers often employ constraints that assume only a single instantiation is executing on a particular machine. Configurations allow each instance to present as a separate user, thus avoiding conflicts that may arise from temporary files and network connections, for example. Each browser instance operates as a performance agent and dynamically links with a set of entry points for accessing performance related browser operations. As each agent invokes native (OS specific) machine functions for network access via particular entry points, configurations disclosed herein redirect the entry points to a collection layer of instructions (code) for capturing performance data in addition to invoking the native OS function called for by the browser operation.

    Abstract translation: 网站测试环境调用商业浏览器的多个实例,并捕获浏览器操作的调用以收集性能数据,而不受其他实例或多次操作系统(OS)的干扰。 商业浏览器通常采用假定在特定机器上仅执行单个实例化的约束。 配置允许每个实例作为单独的用户呈现,从而避免例如由临时文件和网络连接引起的冲突。 每个浏览器实例作为性能代理进行操作,并与一组入口点动态链接以访问性能相关的浏览器操作。 当每个代理器通过特定入口点调用用于网络访问的本机(OS特定)机器功能时,本文公开的配置将入口点重定向到用于捕获性能数据的指令(代码)集合层,以及调用由 浏览器操作。

    MULTIPLE INSTANCE COMMERCIAL BROWSER WEBSITE TEST AGENT
    24.
    发明申请
    MULTIPLE INSTANCE COMMERCIAL BROWSER WEBSITE TEST AGENT 有权
    多个实时商业浏览器网站测试代理

    公开(公告)号:US20110016205A1

    公开(公告)日:2011-01-20

    申请号:US12502502

    申请日:2009-07-14

    CPC classification number: H04L67/22 H04L67/02

    Abstract: A website test environment invokes multiple instances of a commercial browser, and captures invocations of browser operations for gathering performance data without interference from other instances or multiple occurrences of the operating system (OS). Commercial browsers often employ constraints that assume only a single instantiation is executing on a particular machine. Configurations allow each instance to present as a separate user, thus avoiding conflicts that may arise from temporary files and network connections, for example. Each browser instance operates as a performance agent and dynamically links with a set of entry points for accessing performance related browser operations. As each agent invokes native (OS specific) machine functions for network access via particular entry points, configurations disclosed herein redirect the entry points to a collection layer of instructions (code) for capturing performance data in addition to invoking the native OS function called for by the browser operation.

    Abstract translation: 网站测试环境调用商业浏览器的多个实例,并捕获浏览器操作的调用以收集性能数据,而不受其他实例或多次操作系统(OS)的干扰。 商业浏览器通常采用假定在特定机器上仅执行单个实例化的约束。 配置允许每个实例作为单独的用户呈现,从而避免例如由临时文件和网络连接引起的冲突。 每个浏览器实例作为性能代理进行操作,并与一组入口点动态链接以访问性能相关的浏览器操作。 当每个代理器通过特定入口点调用用于网络访问的本机(OS特定)机器功能时,本文公开的配置将入口点重定向到用于捕获性能数据的指令(代码)集合层,以及调用由 浏览器操作。

    MOBILE ROBOT FOR TELECOMMUNICATION
    25.
    发明申请
    MOBILE ROBOT FOR TELECOMMUNICATION 有权
    移动机器人电信

    公开(公告)号:US20100076600A1

    公开(公告)日:2010-03-25

    申请号:US11862197

    申请日:2007-09-27

    Abstract: A mobile robot provides telecommunication service between a remote user at a remote terminal and a local user in proximity to the mobile robot. The remote user can connect to the mobile robot via the Internet using a peer-to-peer VoIP protocol, and control the mobile robot to navigate about the mobile robot's environment. The mobile robot includes a microphone, a video camera and a speaker for providing telecommunication functionality between the remote user and the local user. Also, a hand-held RC unit permits the local user to navigate the mobile robot locally or to engage privacy mode for the mobile robot. When NAT or a firewall obstructs connection from the remote terminal to the mobile robot, an Internet server facilitates connection using methods such as STUN, TURN, or relaying.

    Abstract translation: 移动机器人在远程终端的远程用户和接近移动机器人的本地用户之间提供电信服务。 远程用户可以使用点对点VoIP协议通过因特网连接到移动机器人,并且控制移动机器人来浏览移动机器人的环境。 移动机器人包括麦克风,摄像机和用于在远程用户和本地用户之间提供电信功能的扬声器。 此外,手持RC单元允许本地用户在本地导航移动机器人,或者为移动机器人引入隐私模式。 当NAT或防火墙阻止从远程终端到移动机器人的连接时,因特网服务器使用诸如STUN,TURN或中继的方法便利连接。

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