公开(公告)号：US06673385B1

公开(公告)日：2004-01-06

申请号：US09893957

申请日：2001-06-28

Applicant: Ni Ding ,  Deborra Sanders Millare ,  Syed F. A. Hossainy

Inventor： Ni Ding ,  Deborra Sanders Millare ,  Syed F. A. Hossainy

IPC: A61L2700

CPC classification number: C09D151/08 ,  A61L31/10 ,  C08F290/06 ,  C08F290/061 ,  C08K5/053 ,  C08K5/103 ,  C08K5/1545 ,  C09D133/00 ,  C09D133/06 ,  C09D133/14 ,  C09D151/003 ,  C08L33/00

Abstract: This invention provides a method of forming a polymeric coating for a stent. The method can comprise applying a prepolymer or a combination of prepolymers to the stent and initiating polymerization to form a polymeric coating for the stent. The coating material can optionally contain a biologically active agent or combination of agents.

Abstract translation: 本发明提供一种形成用于支架的聚合物涂层的方法。 该方法可以包括将预聚物或预聚物的组合施加到支架并开始聚合以形成用于支架的聚合物涂层。 涂层材料可任选地含有生物活性剂或试剂的组合。

公开(公告)号：US06284305B1

公开(公告)日：2001-09-04

申请号：US09573506

申请日：2000-05-18

Applicant: Ni Ding ,  Michael N. Helmus

Inventor： Ni Ding ,  Michael N. Helmus

IPC: A61L1300

CPC classification number: A61L33/0011 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/08 ,  C08L71/02 ,  C08L5/00 ,  C08L83/00 ,  C08L83/04

Abstract: A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

Abstract translation: 公开了用于涂覆可植入装置或假体的涂层和方法。 该涂层包括聚合材料的底涂层，其中含有一定量的分散在其中的生物活性材料，特别是肝素。 涂层还包括覆盖低于底涂层整个表面的面漆，并且其中面漆包含基本上不含孔隙和孔隙体的聚合材料。 面漆的聚合材料可以是生物稳定的生物相容性材料，其在生物活性材料释放过程中和之后提供了对器件部分的长期非血栓形成。

公开(公告)号：US6040058A

公开(公告)日：2000-03-21

申请号：US126374

申请日：1998-08-27

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B32B15/08

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶的涂层，使得涂料组合物坚韧地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US5662960A

公开(公告)日：1997-09-02

申请号：US384711

申请日：1995-02-01

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08J7/00 ,  C08J7/04 ,  B05D3/10 ,  B05D3/04 ,  C23C14/02

CPC classification number: B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G2210/00 ,  C08G2270/00

Abstract: A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

公开(公告)号：US08747385B2

公开(公告)日：2014-06-10

申请号：US13468956

申请日：2012-05-10

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

公开(公告)号：US08394446B2

公开(公告)日：2013-03-12

申请号：US12485756

申请日：2009-06-16

Applicant: Ni Ding

Inventor： Ni Ding

IPC: B05D3/00

CPC classification number: A61F2/82 ,  A61L31/10 ,  A61L31/143 ,  B65B55/00 ,  B65D1/00 ,  B65D3/00 ,  B65D77/04 ,  C08K5/13

Abstract: Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Abstract translation: 本发明描述了将抗氧化剂并入包括聚合物的医疗装置中的方法，以及包装医疗装置的方法。

公开(公告)号：US07785647B2

公开(公告)日：2010-08-31

申请号：US11189216

申请日：2005-07-25

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61L33/00

CPC classification number: A61L31/10 ,  Y10T428/1307

Abstract: A method of providing an antioxidant to a medical device is described.

Abstract translation: 描述了向医疗装置提供抗氧化剂的方法。

公开(公告)号：US20090240325A1

公开(公告)日：2009-09-24

申请号：US12052452

申请日：2008-03-20

Applicant: Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

Inventor： Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

IPC: A61F2/06 ,  A61F2/02

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L2420/08 ,  C08L67/04

Abstract: Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.

Abstract translation: 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。

公开(公告)号：US20090069883A1

公开(公告)日：2009-03-12

申请号：US12271265

申请日：2008-11-14

Applicant: Ni Ding ,  W. Scott Andrus

Inventor： Ni Ding ,  W. Scott Andrus

IPC: A61F2/82 ,  A61M25/10

CPC classification number: A61F2/86 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

Abstract: The medical devices of the invention comprise an expandable portion which is covered with a sponge coating for release of at least one biologically active material. The sponge coating is made of a non-hydrogel polymer having a plurality of voids. The device can further include means for infusing or expelling the biologically active material or drug into the voids. The drug is delivered to the body lumen of a patient by expelling the drug and inflating or expanding the expandable portion of the catheter or device.

Abstract translation: 本发明的医疗装置包括可膨胀部分，其被海绵涂层覆盖以释放至少一种生物活性材料。 海绵涂层由具有多个空隙的非水凝胶聚合物制成。 该装置还可以包括用于将生物活性材料或药物注入或排出到空隙中的装置。 通过排出药物并使导管或装置的可扩张部分膨胀或膨胀，将药物输送到患者的体腔。

公开(公告)号：US07462165B2

公开(公告)日：2008-12-09

申请号：US10071400

申请日：2002-02-07

Applicant: Ni Ding ,  W. Scott Andrus

Inventor： Ni Ding ,  W. Scott Andrus

IPC: A61M29/00

CPC classification number: A61F2/86 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

Abstract: The medical devices of the invention comprise an expandable portion which is covered with a sponge coating for release of at least one biologically active material. The sponge coating is made of a non-hydrogel polymer having a plurality of voids. The device can further include means for infusing or expelling the biologically active material or drug into the voids. The drug is delivered to the body lumen of a patient by expelling the drug and inflating or expanding the expandable portion of the catheter or device.

Abstract translation: 本发明的医疗装置包括可膨胀部分，其被海绵涂层覆盖以释放至少一种生物活性材料。 海绵涂层由具有多个空隙的非水凝胶聚合物制成。 该装置还可以包括用于将生物活性材料或药物注入或排出到空隙中的装置。 通过排出药物并使导管或装置的可扩张部分膨胀或膨胀，将药物输送到患者的体腔。