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    Fc binding proteins with cysteine in the C-terminal helical region
    21.
    发明授权
    Fc binding proteins with cysteine in the C-terminal helical region 有权

    公开(公告)号：US12275774B2

    公开(公告)日：2025-04-15

    申请号：US18076443

    申请日：2022-12-07

    Applicant: Repligen Corporation

    Inventor： Erik Fiedler ,  Ulrich Haupts

    IPC: C07K14/735 ,  C07K1/14

    Abstract: The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region. The invention further relates to affinity matrices comprising the Fc binding proteins of the invention. The invention also relates to a use of these Fc binding proteins or affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification using the Fc binding proteins of the invention.

    VARIABLE PATHLENGTH UV SPECTROSCOPY BASED AUTOMATED TFF SYSTEM
    27.
    发明公开
    VARIABLE PATHLENGTH UV SPECTROSCOPY BASED AUTOMATED TFF SYSTEM 审中-公开

    公开(公告)号：US20230294021A1

    公开(公告)日：2023-09-21

    申请号：US18123917

    申请日：2023-03-20

    Applicant: Repligen Corporation

    Inventor： Ramsey Shanbaky ,  Dodd Weisenberger ,  Derek Carroll ,  Paul Lalo ,  Brandon Goldberg

    IPC: B01D29/90 ,  G01N15/06

    CPC classification number: B01D29/908 ,  G01N15/06 ,  G01N21/33

    Abstract: A system for TFF filtration of a feedstock includes a feed vessel containing a solution comprising a target biomolecule, a filter membrane for filtering the solution, a feed pump for moving the solution from the feed vessel to the filter membrane, a buffer vessel coupled to the feed vessel by a buffer supply line, and a diafiltration pump disposed in the buffer supply line for delivering a buffer solution to the feed vessel. A variable path-length instrument is coupled to the feed line for determining, in real time, a concentration of the target biomolecule in the solution. A controller is coupled to the variable path-length instrument, the feed pump, and the diafiltration pump to control operation of the system based on the received information.

    VESSEL, SYSTEM, AND ASSOCIATED METHOD FOR PRODUCT CONCENTRATION
    28.
    发明公开
    VESSEL, SYSTEM, AND ASSOCIATED METHOD FOR PRODUCT CONCENTRATION 审中-公开

    公开(公告)号：US20230211292A1

    公开(公告)日：2023-07-06

    申请号：US18071899

    申请日：2022-11-30

    Applicant: Repligen Corporation

    Inventor： Steven V. Cates ,  Rudolf Pavlik ,  Bao Le

    IPC: B01D61/18 ,  C12M1/00 ,  B01D61/14 ,  B01F27/85

    CPC classification number: B01D61/18 ,  C12M47/02 ,  B01D61/145 ,  B01F27/851 ,  B01D2315/10 ,  B01D63/02

    Abstract: Vessel configured to facilitate concentration of a product in a solution. The vessel may include outlet ports to deliver the solution to a processing system (such as a filtration system), and inlet ports. The inlet ports may be at progressively lower levels for return of fluid thereto reduced in volume as a result of filtration thereof. A smaller volume sump may be provided below a main tank of the vessel to facilitate concentration of the solution. The sump may include ridges facilitating collection of the product of interest from the solution, and/or reinforcing the sump walls, and optionally forming a vortex breaker. A spray ball may be provided to spray materials, such as buffer solution, into the vessel. The spray ball may direct materials to facilitate retrieval of product from the vessel. One or more components of the vessel may be advantageously formed of disposable material for single use thereof.

    Devices, systems, and methods for continuous processing with alternating tangential flow
    29.
    发明授权
    Devices, systems, and methods for continuous processing with alternating tangential flow 有权

    公开(公告)号：US11524262B2

    公开(公告)日：2022-12-13

    申请号：US16940764

    申请日：2020-07-28

    Applicant: REPLIGEN CORPORATION

    Inventor： Mark A. Perreault

    IPC: B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08

    Abstract: The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.

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