公开(公告)号：US5061075A

公开(公告)日：1991-10-29

申请号：US390703

申请日：1989-08-07

Applicant: Robert R. Alfano ,  George R. Nagamatsu ,  Nobutoshi Oka

Inventor： Robert R. Alfano ,  George R. Nagamatsu ,  Nobutoshi Oka

IPC: G01N21/64 ,  G01P13/00

CPC classification number: G01N21/6445 ,  G01P13/00

Abstract: The sperm count of a specimen of sperm is measured by exciting the specimen with a beam of substantially monochromatic light, then measuring the intensity of the intrinsic native fluorescence emitted or the scattered light from the specimen, and then determining the sperm count using the intensity measurements. The motitily of a specimen of sperm is determined by exciting the specimen with a beam of substantially monochromatic polarized light, then measuring the intensity of the parallel and perpendicular components of the intrinsic native fluorescene emitted or the intensity of the scattered light from the specimen at a predetermined wavelength; and then determining the motitily using the two intensity measurements with parallel and perpendicular polarizations.

Abstract translation: 精子样本的精子计数通过激发具有基本上单色光束的样本，然后测量发射的固有天生荧光的强度或来自样本的散射光的强度，然后使用强度测量法确定精子计数 。 通过用基本单色偏振光束激发样本，然后测量发射的本征天然荧光的平行和垂直分量的强度或来自样品的散射光的强度来确定精子标本的动力 预定波长; 然后确定动态地使用具有平行和垂直极化的两个强度测量。

公开(公告)号：US4918635A

公开(公告)日：1990-04-17

申请号：US271566

申请日：1988-11-15

Applicant: Yao Li ,  Robert R. Alfano ,  George Eichmann

Inventor： Yao Li ,  Robert R. Alfano ,  George Eichmann

IPC: G06E1/04

CPC classification number: G06E1/04

Abstract: A technique for performing multiplication oriented optical digital computations in which a pair of identical primary frequency coherent beams of light are directed off-axis through a second harmonic generating crystal to produce an on-axis frequency doubled (i.e. second harmonic) output signal. Each primary beam is encoded with one of the quantities to be multiplied producing an output beam containing the product of the two quantities. The output beam is detected by an array type detector. The technique can be used in performing time integration applications as well as spatial integration applications. For space integration applications a cylindrical lens is positioned in front of the array detector. Multistage operations are realized using a parameteric frequency down conversion and amplification scheme.

Abstract translation: 一种用于执行乘法定向光学数字计算的技术，其中一对相同的主要频率相干光束通过二次谐波产生晶体离轴指向以产生轴上倍频（即二次谐波）输出信号。 每个主光束被编码为要乘以的量之一，产生包含两个量的乘积的输出光束。 输出光束由阵列型检测器检测。 该技术可用于执行时间集成应用程序以及空间集成应用程序。 对于空间集成应用，柱面透镜位于阵列检测器的前面。 使用参数降频转换和放大方案实现多级操作。

公开(公告)号：USRE31815E

公开(公告)日：1985-01-29

申请号：US381170

申请日：1982-05-24

Applicant: Robert R. Alfano

Inventor： Robert R. Alfano

IPC: A61B5/00 ,  A61C19/04 ,  A61M5/00 ,  G01N21/64

CPC classification number: G01N21/6486 ,  A61B5/0088 ,  A61C19/04 ,  A61M5/00

Abstract: A method and apparatus for detecting the presence of caries in human teeth using visible luminescence. A region to be examined is excited with a beam of monochromatic light. The intensity of the visible light emitted from the region is measured at two predetermined wavelengths, one where the intensity dependence of the spectra is about the same for caries and noncaries and the other where the relative intensity increases significantly in the presence of caries. A signal corresponding to the difference in the two intensities is obtained and then displayed. By first determining the magnitude of the difference signal at a nondecayed region, any increases in the magnitude as other regions are probed indicate the presence of caries. The invention is based on the discovery that the visible luminescence spectra for decayed and nondecayed regions of a human tooth are substantially different and that the differences are such that visible luminescence from teeth can be used to detect the presence of caries.

公开(公告)号：US20240133814A1

公开(公告)日：2024-04-25

申请号：US18458988

申请日：2023-08-30

Applicant: Robert R. Alfano

Inventor： Robert R. Alfano ,  Sandra Mamani Reyes

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/06113 ,  G01N2201/0633

Abstract: A method for obtaining a polarized orbital angular momentum Raman spectrum using vector vortex beams, includes the steps of emitting a polarized laser light from a laser source. The polarized laser light is passed through a narrow band filter that is then passed through a section of wave plates (quarter or half wave plate) to generate polarized light (linear, circular, radial and azimuthal), then through a q-plate (vortex retarder or spiral plate) to give a vortex structure topology carrying orbital angular momentum with a helical phase. The polarized vector vortex light is then directed to contact a sample, thereby producing a Raman scatter beam. The Raman scatter beam is passed back and collected into a spectrometer, thereby obtaining a Raman scattering spectrum of the sample to investigate the matching of the multipoles of the material and the multipoles of the light. A method for transmission with Multiple expansions of orbital angular momentum in rat cerebellum tissue is also disclosed. In general, we use polarized Laguerre-Gaussian vector vortex beams as a topology multipole model to describe and study the light matter interaction for Raman and transmission using the fact that the optical vortices and material can possess Multipoles denoted as L in form of monopole (L=0), dipole (L=1), quadrupole (L=2), octupole (L=3), hexidecapole (L=4) and higher orders. These multipoles can be involved with the matching up with the symmetry of the moments involved with vibrational states in Raman processes.

公开(公告)号：US20170049328A1

公开(公告)日：2017-02-23

申请号：US15243607

申请日：2016-08-22

Applicant: Robert R. Alfano ,  Cheng-hui Liu ,  Vidyasagar Sriramoju

Inventor： Robert R. Alfano ,  Cheng-hui Liu ,  Vidyasagar Sriramoju

IPC: A61B5/00 ,  A61B5/02

CPC classification number: A61B5/0086 ,  A61B5/0075 ,  A61B5/02007 ,  A61B2562/0238

Abstract: Vulnerable plaque (VP) is the main cause of death from heart attacks. All currently available methods developed to diagnose VP lack sensitivity and or specificity and are still unable to identify VP. Our patent addresses the problem to diagnose VP in arteries. The teachings here disclose a vulnerable plaque optical analyzer (VPOA) and Imager (VOPAI) for monitoring arterial walls by measuring whether the fingerprint Raman spectrum of adipose (lipid) tissue using Resonance Raman (RR) and common Raman(R) signals of aortic intimal wall layer. The RR and R lines of lipid determine presentation of VP.

Abstract translation: 易受伤害的斑块（VP）是心脏病发作死亡的主要原因。 目前开发用于诊断VP的所有方法缺乏灵敏度和/或特异性，仍然无法识别VP。 我们的专利解决了诊断动脉中VP的问题。 这里的教导公开了通过使用共振拉曼（RR）和主动脉内膜的共同拉曼（R）信号测量脂肪（脂质）组织的指纹拉曼光谱来监测动脉壁的易损斑块光学分析仪（VPOA）和成像仪（VOPAI） 墙层。 脂质的RR和R线决定VP的呈现。

公开(公告)号：US20140300891A1

公开(公告)日：2014-10-09

申请号：US14309598

申请日：2014-06-19

Applicant: ROBERT R. ALFANO ,  Yang Pu ,  Wubao Wang

Inventor： ROBERT R. ALFANO ,  Yang Pu ,  Wubao Wang

IPC: G01N33/02 ,  G01N21/27 ,  G01N21/33

CPC classification number: G01N21/27 ,  G01N21/6486 ,  G01N33/12

Abstract: A method detects the degree of spoilage of food by exposing a food sample to an excitation wave having a first wavelength of about 340 nm or about 380 nm, wherein the excitation wave has a bandwidth of 40 nm or less. The excitation wave is permitted to interact with the food sample and return emission spectra. A detector detects the emission spectra. A predetermined threshold value is established which defines when a food sample is or is not spoiled. The emission spectra is analyzed at a second wavelength of about 400 nm, about 450 nm or about 530 nm to provide a test or measured value of the emission spectra indicative of the degree of spoilage of the food sample. Whether or not a food sample is spoiled beyond the predetermined threshold is determined by comparing the measured value to the predetermined threshold value.

Abstract translation: 一种方法通过将食物样品暴露于第一波长为约340nm或约380nm的激发波来检测食物的变质程度，其中激发波具有40nm或更小的带宽。 激发波被允许与食物样品相互作用并返回发射光谱。 检测器检测发射光谱。 建立了一个预定的阈值，其定义何时食物样本是否被损坏。 在约400nm，约450nm或约530nm的第二波长处分析发射光谱，以提供指示食物样品的变质程度的发射光谱的测试值或测量值。 通过将测量值与预定阈值进行比较来确定食物样品是否损坏超过预定阈值。

公开(公告)号：US08518445B2

公开(公告)日：2013-08-27

申请号：US11656738

申请日：2007-01-22

Applicant: Robert R. Alfano ,  Xiaohui Ni ,  Manuel Zevallos

Inventor： Robert R. Alfano ,  Xiaohui Ni ,  Manuel Zevallos

IPC: A61K9/14

CPC classification number: A61Q1/02 ,  A61K8/0241 ,  A61K8/025 ,  A61K2800/413 ,  A61K2800/42 ,  A61K2800/43 ,  A61K2800/434 ,  A61K2800/651 ,  A61Q1/12 ,  B82Y5/00

Abstract: The present invention teaches how to change the skin color perception, mainly the facial color from red, blue or yellow to white appearance, using quantum and optical principles. By selecting the right size and material of particles compounded in cosmetic preparations and applying the preparations to the skin, the scattering and/or emission from micro- and nanoparticles can provide a complementary color or in proximity to that complementary color of the skin color. The mixture of the color provided by the particles and the reflected color from the skin will whiten the skin or make inconspicuous of the hyperchromic portion of the skin. The invention can also be used for other applications in which the particles can be applied to a surface or blended into a material, such as, for example, automobile paint, house paint, glass color and nail polish.

Abstract translation: 本发明教导如何使用量子和光学原理将皮肤颜色感觉，主要是从红色，蓝色或黄色到白色外观的颜色变化。 通过选择化妆品制剂中复合的颗粒的合适尺寸和材料，并将制剂施用于皮肤，来自微米和纳米颗粒的散射和/或发射可以提供互补色或接近肤色的互补色。 由颗粒提供的颜色和来自皮肤的反射颜色的混合物将使皮肤变白或使皮肤的变色部分不显眼。 本发明也可用于其中可将颗粒施用于表面或掺入材料中的其它应用，例如汽车涂料，房屋涂料，玻璃颜色和指甲油。

公开(公告)号：US08111957B2

公开(公告)日：2012-02-07

申请号：US12498591

申请日：2009-07-07

Applicant: Robert R Alfano ,  Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Aloysius Nolan ,  Henry Sztul

Inventor： Robert R Alfano ,  Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Aloysius Nolan ,  Henry Sztul

IPC: G02B6/26 ,  G01N21/00

CPC classification number: G02B6/024 ,  C03B2203/10 ,  C03B2203/19 ,  C03B2203/32 ,  C03B2205/06 ,  G02B6/14

Abstract: Generation of a cylindrically polarized light beam, and in particular, a hybrid-azimuthal-radial polarization beams, called HARP modes, generated from an input linearly polarized Gaussian beam using a spun optical waveguide device is taught. The HARP modes are comprised of hybrid-azimuthal polarization (HAP) and hybrid-radial polarization (HRP) superposition modes. These beams possess a non-zero local angular momentum density that is spatially varying and a zero total angular momentum.

Abstract translation: 教导了使用旋转光波导装置从输入线性偏振高斯光束产生的圆柱形偏振光束，特别是称为HARP模式的混合方位角 - 径向偏振光束。 HARP模式由混合方位极化（HAP）和混合径向极化（HRP）叠加模式组成。 这些光束具有非零局部角动量密度，其空间变化和零总角动量。

公开(公告)号：US07986989B2

公开(公告)日：2011-07-26

申请号：US11521170

申请日：2006-09-14

Applicant: Robert R. Alfano ,  Aleksandra Alimova ,  Alvin Katz

Inventor： Robert R. Alfano ,  Aleksandra Alimova ,  Alvin Katz

IPC: A61B6/00 ,  G01N21/64 ,  G01N21/76

CPC classification number: A61B5/0059 ,  A61B5/0091

Abstract: The present application is directed to methods for detecting cancerous, pre-cancerous and benign/normal tissue using phosphorescence or the combination of fluorescence and phosphorescence emission from the tissue excited in 280 to 340 nm range. In particular, the application describes methods using a ratio of intensity of fluorescence emission to intensity of phosphorescence emission to provide a rapid cancer, pre-cancer and benign detection method. Normal human breast and prostate tissue, excited in 270 to 300 nm range, express the emission signatures at 340 nm, 440 nm and 500 nm. Cancerous tissue shows only minor emissions at 500 nm, thus the ratio of 340 nm peak to 500 nm peak emission intensities provides information about malignancy of a tissue. Fiber optic based instrumentation can be used to collect the luminescence signal from an area of a tissue less than 1 mm in diameter and using the described method can be screened to determine the state of the tissue sample taken. The combination of fiber optics and 2D translation stage provides 2D maps of intensity's ratio of the tissue surface and aids in localizing the malignancy region of the tissue.

Abstract translation: 本申请涉及使用磷光检测癌症，癌前和良性/正常组织或从280-340nm范围激发的组织的荧光和磷光发射的组合来检测的方法。 特别地，本申请描述了使用荧光发射强度与磷光发射强度之比来提供快速癌症，癌前和良性检测方法的方法。 在270〜300nm范围内激发的正常人体乳腺和前列腺组织在340nm，440nm和500nm处表达发射特征。 癌组织在500nm处仅显示轻微的发射，因此340nm峰值与500nm峰值发射强度之比提供关于组织恶性肿瘤的信息。 可以使用基于光纤的仪器从直径小于1mm的组织的区域收集发光信号，并且可以筛选所描述的方法以确定所采集的组织样品的状态。 纤维光学和2D平移阶段的组合提供了组织表面强度比的2D图，并有助于定位组织的恶性肿瘤区域。

公开(公告)号：US20100317974A1

公开(公告)日：2010-12-16

申请号：US12684739

申请日：2010-01-08

Applicant: Robert R. Alfano ,  Cheng-Hui Liu ,  Wubao Wang ,  Vidyasagar Sriramoju

Inventor： Robert R. Alfano ,  Cheng-Hui Liu ,  Wubao Wang ,  Vidyasagar Sriramoju

IPC: A61B6/00

CPC classification number: A61B5/0075 ,  A61B5/0084 ,  A61B5/02007

Abstract: An apparatus and method of use for detecting vulnerable plaque (VP) in arterial walls is provided. The method includes measuring whether the Raman spectrum of adipose (lipid) tissue signal is present in a Raman signal from aortic intimal wall tissue. The Raman vibration modes for VP are strong bands at about 1435 cm−1, about 2850 cm−1, and about 2892 cm−1 and will be present when the aortic intimal wall tissue is thin.

Abstract translation: 提供了用于检测动脉壁中的易损斑块（VP）的装置和方法。 该方法包括测量脂肪（脂质）组织信号的拉曼光谱是否存在于来自主动脉内膜壁组织的拉曼信号中。 VP的拉曼振动模式在约1435cm-1，约2850cm-1和约2892cm -1处是强带，并且当主动脉内膜壁组织较薄时将呈现。