公开(公告)号：US20050069576A1

公开(公告)日：2005-03-31

申请号：US10669416

申请日：2003-09-25

Applicant: Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

Inventor： Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

IPC: A61K8/14 ,  A61K8/97 ,  A61K9/127 ,  A61P17/06 ,  A61Q19/00 ,  A61K35/78

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/127 ,  A61K36/29 ,  A61Q19/007

Abstract: The present invention provides a skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of Mahonia aquifolium.

Abstract translation: 本发明提供一种在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 本发明还提供了一种获得马鞭草提取物的方法。

公开(公告)号：US06371998B1

公开(公告)日：2002-04-16

申请号：US09602732

申请日：2000-06-26

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: C10L118

CPC classification number: C10L10/02 ,  C10L1/10 ,  C10L1/125 ,  C10L1/1258 ,  C10L1/1266 ,  C10L1/18 ,  C10L1/1824 ,  C10L1/1857 ,  C10L1/19 ,  C10L1/1985 ,  C10L1/24 ,  C10L1/26

Abstract: Liquid energy sources, e.g., liquid fuels comprising lipid vesicles having fuel additives such as water are disclosed herein. The liquid energy sources, methods for preparation, and methods of enhancing engine performance disclosed herein employing the lipid vesicles result in enhanced fuel efficiency and/or lowered engine emissions. The invention further relates to liquid energy sources containing such additives which further comprise a polymeric dispersion assistant, which reduces the interfacial tension and coalescence of vesicles during dispersion process and storage, and thereby provide transparent looks to the liquid energy source.

Abstract translation: 本文公开了液体能源，例如包含具有燃料添加剂如水的脂质囊泡的液体燃料。 液体能源，制备方法以及本文公开的使用脂质囊泡的增强发动机性能的方法导致提高的燃料效率和/或降低的发动机排放。 本发明还涉及含有这种添加剂的液体能源，其进一步包含聚合物分散体助剂，其在分散过程和储存期间降低囊泡的界面张力和聚结，从而为液体能源提供透明的外观。

公开(公告)号：US06251425B1

公开(公告)日：2001-06-26

申请号：US09165436

申请日：1998-10-02

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K9127

CPC classification number: A61K8/604 ,  A61K8/14 ,  A61K9/1272 ,  A61Q19/00 ,  Y10T428/2984

Abstract: Paucilamellar lipid vesicles containing lipid bilayers at least two lipid bilayers formed of surfactant materials, each of the bilayers comprising a glucoside primary amphiphile and a steroid. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract translation: 包含脂质双层的至少两个由表面活性剂材料形成的脂质双层的Paucilamellar脂质囊泡，每个双层包含葡萄糖苷原性两亲物和类固醇。 囊泡可以具有水或油填充的中心腔，并且特别可用于递送皮肤病学，化妆品和药物制剂。 还公开了这些囊泡的制造方法。

公开(公告)号：US5160669A

公开(公告)日：1992-11-03

申请号：US598120

申请日：1990-10-16

Applicant: Donald F. H. Wallach ,  Rajiv Mathur

Inventor： Donald F. H. Wallach ,  Rajiv Mathur

IPC: A61K8/14 ,  A61K9/127 ,  A61Q19/00 ,  B01J13/02 ,  C11D17/00

CPC classification number: A61K9/1272 ,  A61K9/1277 ,  A61K9/1278 ,  C11D17/0021 ,  C11D17/0026 ,  Y10T428/2984

Abstract: A new "cold-loading" technique for filling the amorphous central cavity of paucilamellar lipid vesicles with a water immiscible material has been developed. Preformed, substantially aqueous filled paucilamellar lipid vesicles are mixed with the water immiscible material to be encapsulated under intermediate mixing conditions, thereby replacing the aqueous solution with the water-immiscible solution. The "cold-loading" technique is particularly useful for encapsulation of volatiles and heat labile materials.

Abstract translation: 已经开发了一种新的“冷加载”技术，用于与水不混溶的材料填充二叠层脂质囊泡的无定形中心腔。 预先形成的基本上水充填的薄层脂质囊泡与中间混合条件下待包封的水不混溶材料混合，从而用水不混溶溶液代替水溶液。 “冷加载”技术对挥发物和热不稳定材料的包封特别有用。