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公开(公告)号：US08617158B2
公开(公告)日：2013-12-31
申请号：US12849699
申请日：2010-08-03
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/14 , A61B90/04 , A61B2018/00005 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2090/0445 , A61B2090/0481
摘要： A medical assembly and method are provided to effectively treat abnormal tissue, such as, a tumor. The target tissue is thermally ablated using a suitable source, such as RF or laser energy. A cooling shield is placed in contact with non-target tissue adjacent the target tissue, and actively cooled to conduct thermal energy away from the non-target tissue. In one method, the cooling shield can be placed between two organs, in which case, one of the two organs can comprise the target tissue, and the other of the two organs can comprise the non-target tissue. In this case, the cooling shield may comprise an actively cooled inflatable balloon, which can be disposed between the two organs when deflated, and then inflated. The inflatable balloon can be actively cooled by pumping a cooling medium through it. In another method, the cooling shield can be embedded within the non-target tissue. In this case, the cooling shield can comprise one or more needles. If a plurality of needles is used, they can be embedded into the non-target tissue in a series, e.g., a rectilinear or curvilinear arrangement. The needle(s) can be actively cooled by pumping a cooling medium through them.
摘要翻译： 提供医疗组件和方法来有效地治疗诸如肿瘤的异常组织。 使用适当的来源（例如RF或激光能量）将靶组织热消融。 将冷却屏蔽物放置成与目标组织相邻的非靶组织接触，并且主动冷却以将热能从非目标组织传导出去。 在一种方法中，冷却屏蔽可以放置在两个器官之间，在这种情况下，两个器官中的一个可以包括靶组织，并且两个器官中的另一个可以包括非靶组织。 在这种情况下，冷却屏蔽件可以包括主动冷却的可膨胀气囊，当气体放气时可以将气囊放置在两个器官之间，然后膨胀。 可以通过泵送冷却介质来主动冷却可充气球囊。 在另一种方法中，冷却屏蔽可以嵌入在非目标组织内。 在这种情况下，冷却罩可以包括一个或多个针。 如果使用多个针，则它们可以以一系列例如直线或曲线布置被嵌入到非目标组织中。 可以通过将冷却介质泵送通过它们来主动冷却针。
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公开(公告)号：US08412348B2
公开(公告)日：2013-04-02
申请号：US10841069
申请日：2004-05-06
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device is provided. The medical device comprises an expandable tubular body that includes an integrated resilient support structure that forms a plurality of electrically conductive regions to which the lead(s) is coupled. The tubular body further includes at least one electrically insulative element disposed between the conductive regions. In one embodiment, the support structure is skeletal in nature, e.g., it can be formed of a mesh, braid, or coil. The conductive regions can be variously formed by the support structure. For example, the support structure may comprise electrically conductive sub-structures that form the conductive regions. In this case, the sub-structures may be mechanically linked together by the insulative element(s), or they can be directly linked together, and the insulative element(s) can take the form of insulative layer(s) disposed on one or more of the conductive sub-structures. As another example, the support structure can have a conductive core and insulative material disposed over portions of the conductive core. In this case, the exposed core portions form the conductive regions, and the unexposed core portions form the insulative element(s).
摘要翻译： 提供可扩张血管内医疗装置。 医疗装置包括可扩张的管状体，其包括形成多个导电区域的集成的弹性支撑结构，引线与该多个导电区域相连。 管状体还包括设置在导电区域之间的至少一个电绝缘元件。 在一个实施例中，支撑结构本质上是骨架的，例如，其可以由网，编织物或线圈形成。 导电区域可以由支撑结构各种形成。 例如，支撑结构可以包括形成导电区域的导电子结构。 在这种情况下，子结构可以通过绝缘元件机械地连接在一起，或者它们可以直接连接在一起，并且绝缘元件可以采取设置在一个或多个绝缘元件上的绝缘层的形式， 更多的导电子结构。 作为另一示例，支撑结构可以具有设置在导电芯的部分上方的导电芯和绝缘材料。 在这种情况下，露出的芯部形成导电区域，未曝光的芯部形成绝缘元件。
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公开(公告)号：US07985214B2
公开(公告)日：2011-07-26
申请号：US11040018
申请日：2005-01-19
申请人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
发明人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
IPC分类号： A61M25/00
CPC分类号： A61M25/005 , A61M25/0053
摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.
摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。
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24.发明申请公开(公告)号：US20100256633A1
公开(公告)日：2010-10-07
申请号：US12818091
申请日：2010-06-17
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B90/39 , A61B2018/143 , A61B2018/1432 , A61B2018/1495 , A61B2090/3987 , A61N1/06
摘要： Methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.
摘要翻译： 提供了用于通过在待治疗的组织内植入多个电极装置并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置来烧蚀组织的方法。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。
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25.发明授权公开(公告)号：US07749219B2
公开(公告)日：2010-07-06
申请号：US11258417
申请日：2005-10-24
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B90/39 , A61B2018/143 , A61B2018/1432 , A61B2018/1495 , A61B2090/3987 , A61N1/06
摘要： Methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.
摘要翻译： 提供了用于通过在待治疗的组织内植入多个电极装置并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置来烧蚀组织的方法。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。
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公开(公告)号：US07655006B2
公开(公告)日：2010-02-02
申请号：US11207628
申请日：2005-08-18
CPC分类号： A61B17/12036 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B18/1477 , A61B18/1485 , A61B2017/00557 , A61B2017/22067 , A61B2018/00214 , A61B2018/00577
摘要： Methods and devices for occluding a vessel during a percutaneous ablation procedure. An elongated access device having a lumen and a tissue piercing, open distal end in communication with the lumen is used to percutaneously access a vessel that supplied blood to the tissue to be treated. An elongated balloon deployment device is used to deliver a balloon into the interior of the vessel. The balloon is inflated, resulting in the occlusion of the vessel. The tissue to be treated is ablated. Because there is little or no blood to transfer the thermal energy away from the heated tissue, the ablation procedure is performed more efficiently. The balloon may be subsequently deflated allowing normal flow through the vessel to return.
摘要翻译： 在经皮消融手术期间闭塞血管的方法和装置。 使用具有内腔和与内腔连通的组织刺穿的开放远端的细长的进入装置来经皮地进入供给待处理组织的血液的血管。 使用细长的气囊展开装置将气囊输送到容器的内部。 气球膨胀，导致血管闭塞。 要治疗的组织被消融。 因为很少或没有血液将热能转移到加热的组织之外，因此更有效地进行消融过程。 气球可能随后放气，允许正常流过血管返回。
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公开(公告)号：US07455671B2
公开(公告)日：2008-11-25
申请号：US11867668
申请日：2007-10-04
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译： 提供用于烧伤组织的表面电极。 所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。 针电极的可调性允许针电极穿透组织的深度被调整。
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28.发明授权Intravascular self-anchoring electrode body with arcuate springs, spring loops, or arms 有权血管内自身锚定电极主体具有弧形弹簧，弹簧环或手臂公开(公告)号：US07231260B2
公开(公告)日：2007-06-12
申请号：US10841070
申请日：2004-05-06
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device comprises an arcuate spring configured to be expanded into contact with the inner surface of a blood vessel. Another medical device comprises an electrode support structure, e.g., a non-tubular arcuate structure or a cylindrical member, and a plurality of resilient spring loops laterally extending from the support structure. The contact created between the loops and a blood vessel is sufficient to anchor the medical device within the blood vessel. In another embodiment, the medical device comprises an elongated member and two resilient spring arms extending distally from the elongated member. The arms are configured to be laterally moved towards each other to place the medical device in a collapsed geometry, and configured to be laterally moved away from each into contact with an inner surface of a blood vessel to place the medical device an expanded geometry.
摘要翻译： 可扩张血管内医疗装置包括弓形弹簧，其被构造成膨胀成与血管的内表面接触。 另一医疗装置包括电极支撑结构，例如非管状弓形结构或圆柱形构件，以及从支撑结构横向延伸的多个弹性弹簧环。 在环和血管之间产生的接触足以将医疗装置锚定在血管内。 在另一个实施例中，医疗装置包括细长构件和从细长构件向远侧延伸的两个弹性弹簧臂。 臂被配置为朝向彼此横向移动以将医疗装置放置在折叠的几何形状中，并且被构造成横向移动远离每个与血管的内表面接触，以将医疗装置放置成扩展的几何形状。
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公开(公告)号：US07177702B2
公开(公告)日：2007-02-13
申请号：US10799270
申请日：2004-03-12
IPC分类号： A61N1/00
CPC分类号： A61N1/0553 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0558
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。
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公开(公告)号：US20110022044A1
公开(公告)日：2011-01-27
申请号：US12849699
申请日：2010-08-03
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/14 , A61B90/04 , A61B2018/00005 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2090/0445 , A61B2090/0481
摘要： A medical assembly and method are provided to effectively treat abnormal tissue, such as, a tumor. The target tissue is thermally ablated using a suitable source, such as RF or laser energy. A cooling shield is placed in contact with non-target tissue adjacent the target tissue, and actively cooled to conduct thermal energy away from the non-target tissue. In one method, the cooling shield can be placed between two organs, in which case, one of the two organs can comprise the target tissue, and the other of the two organs can comprise the non-target tissue. In this case, the cooling shield may comprise an actively cooled inflatable balloon, which can be disposed between the two organs when deflated, and then inflated. The inflatable balloon can be actively cooled by pumping a cooling medium through it. In another method, the cooling shield can be embedded within the non-target tissue. In this case, the cooling shield can comprise one or more needles. If a plurality of needles is used, they can be embedded into the non-target tissue in a series, e.g., a rectilinear or curvilinear arrangement. The needle(s) can be actively cooled by pumping a cooling medium through them.
摘要翻译： 提供医疗组件和方法来有效地治疗诸如肿瘤的异常组织。 使用适当的来源（例如RF或激光能量）将靶组织热消融。 将冷却屏蔽物放置成与目标组织相邻的非靶组织接触，并且主动冷却以将热能从非目标组织传导出去。 在一种方法中，冷却屏蔽可以放置在两个器官之间，在这种情况下，两个器官中的一个可以包括靶组织，并且两个器官中的另一个可以包括非靶组织。 在这种情况下，冷却屏蔽件可以包括主动冷却的可膨胀气囊，当气体放气时可以将气囊放置在两个器官之间，然后膨胀。 可以通过泵送冷却介质来主动冷却可充气球囊。 在另一种方法中，冷却屏蔽可以嵌入在非目标组织内。 在这种情况下，冷却罩可以包括一个或多个针。 如果使用多个针，则它们可以以一系列例如直线或曲线布置被嵌入到非目标组织中。 可以通过将冷却介质泵送通过它们来主动冷却针。
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