公开(公告)号：US07985214B2

公开(公告)日：2011-07-26

申请号：US11040018

申请日：2005-01-19

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M25/00

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。

公开(公告)号：US06171295B2

公开(公告)日：2001-01-09

申请号：US09234203

申请日：1999-01-20

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M2500

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。

公开(公告)号：US06866660B2

公开(公告)日：2005-03-15

申请号：US10339055

申请日：2003-01-09

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M25/00 ,  A61M25/16

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。

公开(公告)号：US06508805B1

公开(公告)日：2003-01-21

申请号：US09684819

申请日：2000-10-10

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M2500

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

公开(公告)号：US06942654B1

公开(公告)日：2005-09-13

申请号：US09487359

申请日：2000-01-19

申请人： Dean A. Schaefer ,  David Paulk ,  Steven M. Anderson

发明人： Dean A. Schaefer ,  David Paulk ,  Steven M. Anderson

IPC分类号： A61M25/00 ,  A61F2/06 ,  F16L11/12

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter having a shaft, at least a portion of which includes a braid reinforcement with an axial wire or fiber disposed between the helical members that form the braid. The axial member prevents the elongation of the shaft of the catheter thereby maintaining one-to-one correspondence in axial manipulation of the catheter, even when the shaft is placed in tension. By positioning the axial member between the helical members, the axial member does not create a protrusion and does not become fixed to any adjacent polymer layer. Thus, the axial member limits axial strain of the catheter, without creating the undesirable effects of friction caused by an axial protrusion and without creating the undesirable effects of limited flexure caused by an adjacent polymer layer becoming fixed to the axial member.

摘要翻译： 一种血管内导管，其具有轴，其至少一部分包括编织带加强件，其具有设置在形成编织物的螺旋构件之间的轴线或纤维。 轴向构件防止导管的轴的伸长，从而即使当轴处于张力时也可以在导管的轴向操纵中保持一一对应。 通过将轴向构件定位在螺旋构件之间，轴向构件不产生突起并且不会固定到任何相邻的聚合物层。 因此，轴向构件限制导管的轴向应变，而不产生由轴向突起引起的摩擦的不期望的影响，并且不产生由邻近的聚合物层变得固定到轴向构件而引起的有限挠曲的不期望的影响。

公开(公告)号：US06709429B1

公开(公告)日：2004-03-23

申请号：US09487353

申请日：2000-01-19

申请人： Dean A. Schaefer ,  David Paulk ,  Steven M. Anderson

发明人： Dean A. Schaefer ,  David Paulk ,  Steven M. Anderson

IPC分类号： A61M2500

CPC分类号： D04C1/06 ,  A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter having a shaft, at least a portion of which includes a braid reinforcement with a plurality of axial members disposed between the helical members that form the braid. The axial members provide a number of advantages including: maintaining one-to-one correspondence in axial manipulation; maintaining uniform flexibility in several planes of flexure; reducing the likelihood of causing a curling effect; increasing the strength of connections between shaft segments; uniformly increasing stiffness of the catheter; and increasing the burst strength of the catheter. By positioning the axial members between the helical members, the axial members do not create a protrusion and do not become fixed to any adjacent polymer layer. Thus, the benefits of axial members are retained, without creating the undesirable effects of friction caused by an axial protrusion and without creating the undesirable effects of limited flexure caused by an adjacent polymer layer becoming fixed to the axial member.

摘要翻译： 一种具有轴的血管内导管，其轴的至少一部分包括编织带加强件，其具有设置在形成编织物的螺旋构件之间的多个轴向构件。 轴向构件提供了许多优点，包括：在轴向操纵中保持一一对应; 在几个弯曲平面保持均匀的柔韧性; 降低引起卷曲效应的可能性; 增加轴段之间的连接强度; 均匀增加导管的刚度; 并增加导管的爆裂强度。 通过将轴向构件定位在螺旋构件之间，轴向构件不产生突起并且不会固定到任何相邻的聚合物层。 因此，保持轴向构件的益处，而不产生由轴向突起引起的摩擦的不期望的影响，并且不产生由邻近的聚合物层变得固定到轴向构件引起的有限挠曲的不良影响。

公开(公告)号：US06586826B1

公开(公告)日：2003-07-01

申请号：US09881344

申请日：2001-06-13

申请人： Thomas P. Glenn ,  Steven M. Anderson ,  Steven Webster

发明人： Thomas P. Glenn ,  Steven M. Anderson ,  Steven Webster

IPC分类号： H01L2302

CPC分类号： H01L23/13 ,  H01L24/45 ,  H01L24/48 ,  H01L25/105 ,  H01L2224/05571 ,  H01L2224/05573 ,  H01L2224/16 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73204 ,  H01L2225/1023 ,  H01L2225/1058 ,  H01L2225/107 ,  H01L2924/00014 ,  H01L2924/01028 ,  H01L2924/0105 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/14 ,  H01L2924/15153 ,  H01L2924/15165 ,  H01L2924/15331 ,  H01L2924/181 ,  H05K1/119 ,  H05K1/144 ,  H05K3/062 ,  H05K3/3436 ,  H05K3/368 ,  H05K3/4614 ,  H05K2201/09045 ,  H05K2201/09118 ,  H05K2203/167 ,  H01L2224/05599 ,  H01L2924/00012

摘要： Integrated circuit packages that may be easily stacked one on top of the other are disclosed. The package includes a molded plastic body having metal-coated interconnection posts on both its upper and lower surfaces. An integrated circuit is mounted on the upper surface. Metal traces on the upper surface electrically connect each bonding pad on the integrated circuit to a one of a plurality of groups of four interconnection posts on the upper surface. Vias through the substrate electrically connect each group of four posts on the upper surface to an interconnection post on the lower surface of the package. Two or more packages can be stacked and electrically connected by wedging the lower posts of a top package between each group of four posts on the upper surface of a lower package. The lower posts of the lower package may be soldered to a conventional printed circuit board, or may be mounted on a mounting substrate that also has corresponding groups of four interconnection posts.

摘要翻译： 公开了可以容易地堆叠在另一个之上的集成电路封装。 该包装包括在其上表面和下表面上具有金属涂覆的互连柱的模制塑料体。 集成电路安装在上表面。 上表面上的金属迹线将集成电路上的每个接合焊盘电连接到上表面上的多组四个互连柱中的一组。 通过衬底的通孔将上表面上的每组四个柱电连接到封装的下表面上的互连柱。 可以通过将下封装的上表面上的每组四个支柱之间的顶部封装的下部柱楔入来堆叠并电连接两个或更多个封装。 下部封装的下部管柱可以焊接到传统的印刷电路板上，或者可以安装在也具有相应组的四个互连柱的安装基板上。

公开(公告)号：US5989984A

公开(公告)日：1999-11-23

申请号：US946413

申请日：1997-10-07

申请人： Steven M. Anderson ,  Sundar S. Chetlur

发明人： Steven M. Anderson ,  Sundar S. Chetlur

IPC分类号： H01L21/768 ,  H01L21/30 ,  H01L21/44

CPC分类号： H01L21/76838 ,  H01L21/76802 ,  Y10S438/906

摘要： The present invention provides a method of using a getter layer on a semiconductor substrate having a first metal stack formed thereon to improve metal to metal contact resistance. The method comprises the steps of forming a getter layer, which may be titanium, on the first metal stack, wherein the getter layer has a higher affinity for oxygen or a higher getter capability than the first metal stack, substantially removing the getter layer by exposing the getter layer to radiation, and forming a second metal stack, which in an advantageous embodiment may also be titanium, on the first metal stack.

摘要翻译： 本发明提供一种在其上形成有第一金属叠层的半导体衬底上使用吸气剂层以提高金属与金属接触电阻的方法。 该方法包括以下步骤：在第一金属叠层上形成可为钛的吸气剂层，其中吸气剂层具有比第一金属叠层更高的氧亲合力或更高的吸气能力，通过暴露基本上去除吸气剂层 吸气剂层辐射，并且在第一金属叠层上形成第二金属叠层，其在有利的实施例中也可以是钛。

公开(公告)号：US20120214864A1

公开(公告)日：2012-08-23

申请号：US13390460

申请日：2010-08-16

申请人： Jennifer Richer ,  Dawn Cochrane ,  Steven M. Anderson

发明人： Jennifer Richer ,  Dawn Cochrane ,  Steven M. Anderson

IPC分类号： A61K31/7088 ,  C40B30/04 ,  A61N5/00 ,  A61K31/713 ,  A61P35/00 ,  C12Q1/68 ,  A61K31/365

CPC分类号： C12Q1/6886 ,  C12Q2600/178

摘要： The invention provides methods of diagnosing and treating cancer in a subject. The inventors have identified a series of dysregulated miRNAs that are indicative of triple-negative breast cancer. In some embodiments, the invention further provides for the administration of a cancer therapy to the subject.

摘要翻译： 本发明提供了在受试者中诊断和治疗癌症的方法。 本发明人已经鉴定了一系列失调的miRNA，其指示三阴性乳腺癌。 在一些实施方案中，本发明进一步提供对受试者的癌症治疗的施用。

公开(公告)号：US20090286731A1

公开(公告)日：2009-11-19

申请号：US12304359

申请日：2007-06-12

申请人： Steven M. Anderson ,  Kirsten H. Limesand

发明人： Steven M. Anderson ,  Kirsten H. Limesand

IPC分类号： A61K38/18 ,  A61K38/16

CPC分类号： A61K38/30 ,  A61K41/00 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for the treatment of xerostomia are described, hi particular, the present invention takes advantage of the inventors' observation that xerostomia is caused by induction of apoptosis, and can be inhibited by interfering with the cellular processes that trigger apoptosis in cells receiving chemo- and/or radiotherapy.

摘要翻译： 描述了口腔干燥症的治疗方法。特别地，本发明利用本发明人的观察结果，口腔干燥症是由细胞凋亡的诱导引起的，并且可以通过干扰触发细胞接受化学和/ /或放射治疗。