公开(公告)号：US06586826B1

公开(公告)日：2003-07-01

申请号：US09881344

申请日：2001-06-13

申请人： Thomas P. Glenn ,  Steven M. Anderson ,  Steven Webster

发明人： Thomas P. Glenn ,  Steven M. Anderson ,  Steven Webster

IPC分类号： H01L2302

CPC分类号： H01L23/13 ,  H01L24/45 ,  H01L24/48 ,  H01L25/105 ,  H01L2224/05571 ,  H01L2224/05573 ,  H01L2224/16 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73204 ,  H01L2225/1023 ,  H01L2225/1058 ,  H01L2225/107 ,  H01L2924/00014 ,  H01L2924/01028 ,  H01L2924/0105 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/14 ,  H01L2924/15153 ,  H01L2924/15165 ,  H01L2924/15331 ,  H01L2924/181 ,  H05K1/119 ,  H05K1/144 ,  H05K3/062 ,  H05K3/3436 ,  H05K3/368 ,  H05K3/4614 ,  H05K2201/09045 ,  H05K2201/09118 ,  H05K2203/167 ,  H01L2224/05599 ,  H01L2924/00012

摘要： Integrated circuit packages that may be easily stacked one on top of the other are disclosed. The package includes a molded plastic body having metal-coated interconnection posts on both its upper and lower surfaces. An integrated circuit is mounted on the upper surface. Metal traces on the upper surface electrically connect each bonding pad on the integrated circuit to a one of a plurality of groups of four interconnection posts on the upper surface. Vias through the substrate electrically connect each group of four posts on the upper surface to an interconnection post on the lower surface of the package. Two or more packages can be stacked and electrically connected by wedging the lower posts of a top package between each group of four posts on the upper surface of a lower package. The lower posts of the lower package may be soldered to a conventional printed circuit board, or may be mounted on a mounting substrate that also has corresponding groups of four interconnection posts.

摘要翻译： 公开了可以容易地堆叠在另一个之上的集成电路封装。 该包装包括在其上表面和下表面上具有金属涂覆的互连柱的模制塑料体。 集成电路安装在上表面。 上表面上的金属迹线将集成电路上的每个接合焊盘电连接到上表面上的多组四个互连柱中的一组。 通过衬底的通孔将上表面上的每组四个柱电连接到封装的下表面上的互连柱。 可以通过将下封装的上表面上的每组四个支柱之间的顶部封装的下部柱楔入来堆叠并电连接两个或更多个封装。 下部封装的下部管柱可以焊接到传统的印刷电路板上，或者可以安装在也具有相应组的四个互连柱的安装基板上。

公开(公告)号：US06171295B2

公开(公告)日：2001-01-09

申请号：US09234203

申请日：1999-01-20

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M2500

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。

公开(公告)号：US5989984A

公开(公告)日：1999-11-23

申请号：US946413

申请日：1997-10-07

申请人： Steven M. Anderson ,  Sundar S. Chetlur

发明人： Steven M. Anderson ,  Sundar S. Chetlur

IPC分类号： H01L21/768 ,  H01L21/30 ,  H01L21/44

CPC分类号： H01L21/76838 ,  H01L21/76802 ,  Y10S438/906

摘要： The present invention provides a method of using a getter layer on a semiconductor substrate having a first metal stack formed thereon to improve metal to metal contact resistance. The method comprises the steps of forming a getter layer, which may be titanium, on the first metal stack, wherein the getter layer has a higher affinity for oxygen or a higher getter capability than the first metal stack, substantially removing the getter layer by exposing the getter layer to radiation, and forming a second metal stack, which in an advantageous embodiment may also be titanium, on the first metal stack.

摘要翻译： 本发明提供一种在其上形成有第一金属叠层的半导体衬底上使用吸气剂层以提高金属与金属接触电阻的方法。 该方法包括以下步骤：在第一金属叠层上形成可为钛的吸气剂层，其中吸气剂层具有比第一金属叠层更高的氧亲合力或更高的吸气能力，通过暴露基本上去除吸气剂层 吸气剂层辐射，并且在第一金属叠层上形成第二金属叠层，其在有利的实施例中也可以是钛。

公开(公告)号：US08430105B2

公开(公告)日：2013-04-30

申请号：US13106563

申请日：2011-05-12

申请人： Janel L. Lanphere ,  Paul DiCarlo ,  Steven M. Anderson

发明人： Janel L. Lanphere ,  Paul DiCarlo ,  Steven M. Anderson

IPC分类号： A61B19/00

CPC分类号： A61B18/18 ,  A61B18/14 ,  A61B18/1815 ,  A61B90/04 ,  A61B2017/008 ,  A61B2090/0472 ,  A61B2090/0481 ,  A61B2090/049 ,  A61K9/0019 ,  A61K47/30 ,  A61L27/3683 ,  A61N7/02

摘要： Polymer insulators and methods of using polymer insulators are disclosed. In some embodiments, a method includes separating a first portion of a subject's tissue from a second portion of the subject's tissue so that there is a space between the first and second portions of tissue. Deionized water, a buffered saline solution, liquid polymers, gels, particles, foams, and/or gases are disposed between the first and second portions of tissue, and the first portion of tissue is exposed to energy to treat the first portion of tissue.

摘要翻译： 公开了聚合物绝缘体和使用聚合物绝缘体的方法。 在一些实施例中，一种方法包括将受试者组织的第一部分与受试者组织的第二部分分开，使得在组织的第一和第二部分之间存在空间。 去离子水，缓冲盐溶液，液体聚合物，凝胶，颗粒，泡沫和/或气体设置在组织的第一和第二部分之间，并且组织的第一部分暴露于能量以处理组织的第一部分。

公开(公告)号：US08318008B1

公开(公告)日：2012-11-27

申请号：US12542595

申请日：2009-08-17

申请人： Steven M. Anderson

发明人： Steven M. Anderson

IPC分类号： B01D21/24

CPC分类号： C02F3/006 ,  B01D21/0012 ,  B01D21/2405 ,  B01D21/2427 ,  C02F3/105 ,  C02F3/223 ,  C02F3/2806 ,  C02F3/308 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2101/163 ,  C02F2101/30 ,  C02F2103/005 ,  C02F2201/007 ,  C02F2209/001 ,  C02F2209/40 ,  C02F2209/42 ,  C02F2303/20 ,  C02F2305/06 ,  Y02W10/15 ,  Y02W10/37

摘要： A modular, on-site, wastewater treatment system removes total nitrogen, phosphorus, BOD, and TSS. A flow equalization module provides a constant flow rate to the system eliminating the adverse effects from variations in flow rate throughout the day. Treatment modules are similarly sized to provide a compact, modular system. The nitrification module is a fixed-film, flooded packed bioreactor to facilitate bioconversion of ammonia to nitrate. Aeration of the module provides the oxygen needed for the bioconversion as well prevents clogging of the film. Solids from the nitrification process are removed in a first cone-shaped settling tank. De-nitrification where nitrate is converted to nitrogen gas takes place in an anaerobic fixed-film bioreactor. Carbon-based bio-film carriers provide a carbon source for de-nitrification. A final cone-shaped settling tank separates solids from the treated wastewater. Additional modules to address removal of phosphorous or other contaminants can be added to the modular system.

摘要翻译： 模块化的现场废水处理系统可以去除总氮，磷，BOD和TSS。 流量均衡模块为系统提供恒定的流量，消除了全天流量变化的不利影响。 处理模块的尺寸相似，以提供紧凑的模块化系统。 硝化模块是一种固定膜，淹没的生物反应器，用于促进氨转化为硝酸盐。 模块的曝气提供生物转化所需的氧气，同时防止膜的堵塞。 在第一锥形沉淀槽中除去来自硝化过程的固体。 在厌氧固定膜生物反应器中进行硝酸盐转化为氮气的脱硝。 碳基生物膜载体提供了用于脱硝的​​碳源。 最终的锥形沉淀池将固体与经处理的废水分开。 可以向模块化系统添加用于解决磷或其他污染物去除的附加模块。

公开(公告)号：US20070088347A1

公开(公告)日：2007-04-19

申请号：US11250063

申请日：2005-10-13

申请人： Kimbolt Young ,  Steven M. Anderson ,  John Spiridigliozzi ,  Paul DiCarlo

发明人： Kimbolt Young ,  Steven M. Anderson ,  John Spiridigliozzi ,  Paul DiCarlo

IPC分类号： A61B18/14

CPC分类号： A61B18/1477

摘要： A tissue ablation assembly comprises an elongate probe device, at least one ablation electrode element carried by the probe device for conveying ablation energy, and at least one magnetic element for substantially altering the path of the ablation energy conveyed by the electrode element(s). In one embodiment, the magnetic element substantially urges the ablation energy radially outward. In another embodiment, magnetic element takes the form of a ring magnet that exhibits at least four alternating magnetic poles circumferentially disposed around the probe device axis. A method of treating tissue (e.g., a tumor) is also provided. The method comprises introducing a probe device into the patient, conveying ablation energy from the probe device, and applying a magnetic field adjacent the probe device to substantially alter the path of the ablation energy, e.g., by urging the ablation energy conveyed from the probe device radially outward into the tissue to create a tissue lesion, or by urging the ablation energy longitudinally.

摘要翻译： 组织消融组件包括细长的探针装置，由探针装置承载的用于传送消融能量的至少一个消融电极元件以及用于基本上改变由电极元件传送的消融能量的路径的至少一个磁性元件。 在一个实施例中，磁性元件基本上推动消融能量径向向外。 在另一个实施例中，磁性元件呈环形磁铁的形式，其呈现围绕探针器件轴线周向设置的至少四个交变磁极。 还提供了治疗组织（例如肿瘤）的方法。 该方法包括将探针装置引入患者体内，从探针装置输送消融能量，以及施加邻近探针装置的磁场，以基本上改变消融能量的路径，例如通过促使从探针装置传送的消融能量 径向向外进入组织以产生组织损伤，或通过纵向推动消融能量。

公开(公告)号：US06508805B1

公开(公告)日：2003-01-21

申请号：US09684819

申请日：2000-10-10

申请人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

发明人： Robert J. Garabedian ,  John Griego ,  Earl Bardsley ,  Dean A. Schaefer ,  Cang D. Dao ,  Steven M. Anderson

IPC分类号： A61M2500

CPC分类号： A61M25/005 ,  A61M25/0053

摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

公开(公告)号：US06228748B1

公开(公告)日：2001-05-08

申请号：US09370963

申请日：1999-08-10

申请人： Steven M. Anderson ,  Sundar S. Chetlur

发明人： Steven M. Anderson ,  Sundar S. Chetlur

IPC分类号： H01L21322

CPC分类号： H01L21/76838 ,  H01L21/76802 ,  Y10S438/906

摘要： The present invention provides a method of using a getter layer on a semiconductor substrate having a first metal stack formed thereon to improve metal to metal contact resistance. The method comprises the steps of forming a getter layer, which may be titanium, on the first metal stack, wherein the getter layer has a higher affinity for oxygen or a higher getter capability than the first metal stack, substantially removing the getter layer by exposing the getter layer to radiation, and forming a second metal stack, which in an advantageous embodiment may also be titanium, on the first metal stack.

摘要翻译： 本发明提供一种在其上形成有第一金属叠层的半导体衬底上使用吸气剂层以提高金属与金属接触电阻的方法。 该方法包括以下步骤：在第一金属叠层上形成可为钛的吸气剂层，其中吸气剂层具有比第一金属叠层更高的氧亲合力或更高的吸气能力，通过暴露基本上去除吸气剂层 吸气剂层辐射，并且在第一金属叠层上形成第二金属叠层，其在有利的实施例中也可以是钛。

公开(公告)号：US20120214864A1

公开(公告)日：2012-08-23

申请号：US13390460

申请日：2010-08-16

申请人： Jennifer Richer ,  Dawn Cochrane ,  Steven M. Anderson

发明人： Jennifer Richer ,  Dawn Cochrane ,  Steven M. Anderson

IPC分类号： A61K31/7088 ,  C40B30/04 ,  A61N5/00 ,  A61K31/713 ,  A61P35/00 ,  C12Q1/68 ,  A61K31/365

CPC分类号： C12Q1/6886 ,  C12Q2600/178

摘要： The invention provides methods of diagnosing and treating cancer in a subject. The inventors have identified a series of dysregulated miRNAs that are indicative of triple-negative breast cancer. In some embodiments, the invention further provides for the administration of a cancer therapy to the subject.

摘要翻译： 本发明提供了在受试者中诊断和治疗癌症的方法。 本发明人已经鉴定了一系列失调的miRNA，其指示三阴性乳腺癌。 在一些实施方案中，本发明进一步提供对受试者的癌症治疗的施用。

公开(公告)号：US20090286731A1

公开(公告)日：2009-11-19

申请号：US12304359

申请日：2007-06-12

申请人： Steven M. Anderson ,  Kirsten H. Limesand

发明人： Steven M. Anderson ,  Kirsten H. Limesand

IPC分类号： A61K38/18 ,  A61K38/16

CPC分类号： A61K38/30 ,  A61K41/00 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for the treatment of xerostomia are described, hi particular, the present invention takes advantage of the inventors' observation that xerostomia is caused by induction of apoptosis, and can be inhibited by interfering with the cellular processes that trigger apoptosis in cells receiving chemo- and/or radiotherapy.

摘要翻译： 描述了口腔干燥症的治疗方法。特别地，本发明利用本发明人的观察结果，口腔干燥症是由细胞凋亡的诱导引起的，并且可以通过干扰触发细胞接受化学和/ /或放射治疗。