公开(公告)号：US20070098990A1

公开(公告)日：2007-05-03

申请号：US11120650

申请日：2005-05-03

Applicant: Ronald Cook ,  Silvia Luebben ,  Andrew Myers ,  Bryan Smith ,  Brian Elliott ,  Cory Kreutzer ,  Carolina Wilson ,  Manfred Meiser

Inventor： Ronald Cook ,  Silvia Luebben ,  Andrew Myers ,  Bryan Smith ,  Brian Elliott ,  Cory Kreutzer ,  Carolina Wilson ,  Manfred Meiser

IPC: B32B1/00 ,  C08K9/02

CPC classification number: B01J2/30 ,  B82Y30/00 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2006/12 ,  C08K3/22 ,  C08K3/346 ,  C08K9/04 ,  C09C1/24 ,  C09C1/407 ,  C09D5/082 ,  C09D163/00 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2998 ,  C08L2666/54

Abstract: Surface-modified nanoparticles of boehmite, and methods for preparing the same. Aluminum oxyhydroxide nanoparticles are surface modified by reaction with selected amounts of organic acids. In particular, the nanoparticle surface is modified by reactions with two or more different carboxylic acids, at least one of which is an organic carboxylic acid. The product is a surface modified boehmite nanoparticle that has an inorganic aluminum oxyhydroxide core, or part aluminum oxyhydroxide core and a surface-bonded organic shell. Organic carboxylic acids of this invention contain at least one carboxylic acid group and one carbon-hydrogen bond. One embodiment of this invention provides boehmite nanoparticles that have been surface modified with two or more acids one of which additional carries at least one reactive functional group. Another embodiment of this invention provides boehmite nanoparticles that have been surface modified with multiple acids one of which has molecular weight or average molecular weight greater than or equal to 500 Daltons. Yet, another embodiment of this invention provides boehmite nanoparticles that are surface modified with two or more acids one of which is hydrophobic in nature and has solubility in water of less than 15 by weight. The products of the methods of this invention have specific useful properties when used in mixture with liquids, as filler in solids, or as stand-alone entities.

Abstract translation: 勃姆石的表面改性纳米颗粒及其制备方法。 羟基氧化铝纳米颗粒通过与选定量的有机酸反应进行表面改性。 特别地，通过与两种或多种不同羧酸的反应来修饰纳米颗粒表面，其中至少一种是有机羧酸。 该产品是具有无机氢氧化铝核心或部分羟基氧化铝核心和表面键合有机壳体的表面改性勃姆石纳米颗粒。 本发明的有机羧酸含有至少一个羧酸基和一个碳 - 氢键。 本发明的一个实施方案提供已经用两种或多种酸进行表面改性的勃姆石纳米颗粒，其中一种还含有至少一个反应性官能团。 本发明的另一个实施方案提供已经用多种酸进行表面改性的勃姆石纳米颗粒，其中一种具有大于或等于500道尔顿的分子量或平均分子量。 然而，本发明的另一个实施方案提供了用两种或更多种酸进行表面改性的勃姆石纳米粒子，其中一种酸性质是疏水性的，并且在水中的溶解度小于15重量％。 当与液体混合使用时，本发明方法的产品具有特定的有用特性，作为固体中的填料或作为独立实体。

公开(公告)号：US20050272088A1

公开(公告)日：2005-12-08

申请号：US11192705

申请日：2005-07-29

Applicant: Ronald Cook ,  Matt Lyttle ,  Daren Dick

Inventor： Ronald Cook ,  Matt Lyttle ,  Daren Dick

IPC: C07B61/00 ,  C07D241/46 ,  C07F9/09 ,  C07F9/24 ,  C07H21/00 ,  C09B31/043 ,  C09B56/00 ,  C12Q1/68 ,  C07H21/04 ,  C09B31/072

CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07C245/08 ,  C07D241/46 ,  C07F9/091 ,  C07F9/2408 ,  C09B31/043 ,  C09B56/00 ,  C09B56/12 ,  C12Q1/6818 ,  C40B40/00 ,  G01N33/542 ,  G01N33/582

Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

Abstract translation: 本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。 还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。

公开(公告)号：US08106063B2

公开(公告)日：2012-01-31

申请号：US12508934

申请日：2009-07-24

Applicant: Mark Ebden ,  Premji Meghani ,  Colin Bennion ,  Anthony Ronald Cook ,  Roger Victor Bonnert

Inventor： Mark Ebden ,  Premji Meghani ,  Colin Bennion ,  Anthony Ronald Cook ,  Roger Victor Bonnert

IPC: A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00 ,  C07D239/46 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D405/12 ,  C07D405/14

CPC classification number: C07D239/48 ,  C07D239/69 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis, psoriasis or cancer.

Abstract translation: 用于治疗哮喘，过敏性鼻炎，COPD，炎症性肠病，肠易激综合征，骨关节炎，骨质疏松症，类风湿性关节炎，牛皮癣或癌症的式（I）化合物，其药学上可接受的盐，溶剂合物或体内可水解的酯。

公开(公告)号：US08017602B2

公开(公告)日：2011-09-13

申请号：US12486854

申请日：2009-06-18

Applicant: Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Richard Evans ,  Piotr Raubo

Inventor： Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Richard Evans ,  Piotr Raubo

IPC: C07D265/36 ,  A61K31/536 ,  A61K31/56

CPC classification number: C07D231/12 ,  A61K31/538 ,  A61K45/06 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明提供式（I）化合物，其中W，R 1，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US07442669B2

公开(公告)日：2008-10-28

申请号：US10382132

申请日：2003-03-05

Applicant: David Wickham ,  Ronald Cook

Inventor： David Wickham ,  Ronald Cook

IPC: C01F7/02

CPC classification number: C01G55/002 ,  B01J21/04 ,  B01J23/002 ,  B01J23/34 ,  B01J35/1009 ,  B01J37/30 ,  B01J2523/00 ,  C01F7/021 ,  C01F17/0025 ,  C01G45/006 ,  C01P2002/50 ,  C01P2006/13 ,  F23C13/08 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/72 ,  B01J2523/31 ,  B01J2523/824

Abstract: The present invention provides metal-exchanged hexaaluminate catalysts that exhibit good catalytic activity and/or stability at high temperatures for extended periods with retention of activity as combustion catalysts, and more generally as oxidation catalysts, that make them eminently suitable for use in methane combustion, particularly for use in natural gas fired gas turbines. The hexaaluminate catalysts of this invention are of particular interest for methane combustion processes for minimization of the generation of undesired levels (less than about 10 ppm) of NOx species. Metal exchanged hexaaluminate oxidation catalysts are also useful for oxidation of volatile organic compounds (VOC), particularly hydrocarbons. Metal exchanged hexaaluminate oxidation catalysts are further useful for partial oxidation, particularly at high temperatures, of reduced species, particularly hydrocarbons (alkanes and alkenes).

Abstract translation: 本发明提供了金属交换的六铝酸盐催化剂，其在高温下长时间显示出良好的催化活性和/或稳定性，同时保留作为燃烧催化剂的活性，更一般地，其作为氧化催化剂，使其非常适合用于甲烷燃烧， 特别适用于天然气燃气轮机。 本发明的六铝酸盐催化剂对于最小化NOx物质的不期望水平（小于约10ppm）的产生的甲烷燃烧过程是特别有意义的。 金属交换的六铝酸盐氧化催化剂也可用于挥发性有机化合物（VOC），特别是烃的氧化。 金属交换的六铝酸盐氧化催化剂还可用于部分氧化，特别是在高温下的还原物质，特别是烃（烷烃和烯烃）。

公开(公告)号：US07327836B2

公开(公告)日：2008-02-05

申请号：US10151486

申请日：2002-05-20

Applicant: Clifford Neil Didcock ,  Charles Ronald Cook ,  Michael Geoffrey Andrew Wilson

Inventor： Clifford Neil Didcock ,  Charles Ronald Cook ,  Michael Geoffrey Andrew Wilson

IPC: H04M1/64

CPC classification number: H04M3/5307 ,  H04M3/53325 ,  H04M2203/4509

Abstract: There is disclosed a unified messaging system in which a voice mail domain object comprising a plurality of fields is provided. At least one of such fields is selected to be defined as an open field such that it is accessible to an administration application of the system. The open fields are preferably stored as a voice mail domain summary in the e-mail directory of the unified messaging system.

Abstract translation: 公开了一种统一的消息系统，其中提供了包括多个字段的语音邮件域对象。 选择这样的字段中的至少一个被定义为打开的字段，使得它可以被系统的管理应用访问。 打开的字段优选地作为语音邮件域摘要存储在统一消息收发系统的电子邮件目录中。