公开(公告)号：US20200318050A1

公开(公告)日：2020-10-08

申请号：US16838511

申请日：2020-04-02

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： SCOTT WOOD ,  RAM SARASWAT

IPC: C12M1/12 ,  C12N5/077

Abstract: The present disclosure describes hydrogels which are micropatterned with a network of wells for cell culture. In a preferred embodiment, the micropatterned hydrogels are embedded with a nanomaterial. Further described are methods of forming the micropatterned hydrogels and methods of culturing cells in the micropatterned hydrogels. The hydrogels can be natural or synthetic.

公开(公告)号：US10429400B2

公开(公告)日：2019-10-01

申请号：US15309293

申请日：2015-05-07

Applicant: South Dakota Board of Regents ,  Rochester Institute of Technology

Inventor： Daniel Heglund ,  Andrew Olson ,  Scott Williams ,  Neal Hodges ,  Joseph A. Marshall

IPC: G01N33/94 ,  G01N21/78 ,  G01N33/52 ,  G01N31/22

Abstract: The present invention relates to methods of testing medications to evaluate authenticity and identify counterfeits. The testing methods employ a reactive system comprising a solvent and an acid. Optionally, the reactive system can also comprise an organometallic agent. The testing methods can provide rapid results verifying the authenticity of an antimalarial medication. Further the test method can provide clear results that can be implemented and interpreted without special training, anywhere in the world. The test methods can offer quantitative and qualitative results. The test methods are based on reactions that yield different colors where the color can indicate the presence of an active ingredient, and the intensity of the color can indicate the concentration of the active ingredient.

公开(公告)号：US10387698B2

公开(公告)日：2019-08-20

申请号：US15552486

申请日：2016-02-19

Applicant: South Dakota Board of Regents

Inventor： David Langerman ,  Jon Kellar ,  William Cross ,  P. Stanley May ,  Julian Brackins ,  Jeevan Meruga ,  Aravind Baride ,  John Rapp

IPC: G06K7/10 ,  C09D11/50 ,  B42D25/29 ,  C09D11/037 ,  B42D25/382 ,  C09D11/03 ,  C09K11/77 ,  G06K7/14 ,  G01N21/00 ,  G07D7/00 ,  G01N21/64 ,  H01L23/00

Abstract: An improved system and method for reading an upconversion response from nanoparticle inks is provided. A is adapted to direct a near-infrared excitation wavelength at a readable indicia, resulting in a near-infrared emission wavelength created by the upconverting nanoparticle inks. A short pass filter may filter the near-infrared excitation wavelength. A camera is in operable communication with the short pass filter and receives the near-infrared emission wavelength of the readable indicia. The system may further include an integrated circuit adapted to receive the near-infrared emission wavelength from the camera and generate a corresponding signal. A readable application may be in operable communication with the integrated circuit. The readable application receives the corresponding signal, manipulates the signal, decodes the signal into an output, and displays and/or stores the output.

公开(公告)号：US10376574B2

公开(公告)日：2019-08-13

申请号：US15991794

申请日：2018-05-29

Applicant: South Dakota Board of Regents

Inventor： Victor Huber ,  Ying Fang

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/00

Abstract: Disclosed herein are compositions and methods useful for immunizing a subject against disease caused by influenza A. Disclosed methods comprise administering to the subject an immunoprotective dose of an immunogenic composition. In certain aspects, the immunogenic composition is a vaccine comprised of a recombinant chimeric hemagglutinin polypeptide. In certain aspects, the subject is a mammal. In further aspects, the mammal is a pig. In still further aspects, the mammal is a human.

公开(公告)号：US20190235477A1

公开(公告)日：2019-08-01

申请号：US16312187

申请日：2017-06-21

Applicant: South Dakota Board of Regents

Inventor： Christian Widener ,  Victor Champagne ,  Robert Hrabe

IPC: G05B19/4155 ,  C23C24/04

CPC classification number: G05B19/4155 ,  C22C38/02 ,  C22C38/08 ,  C23C24/04 ,  G05B2219/32228

Abstract: The present disclosure addresses limitations with methods, systems and processes for integrating multiple advanced technologies into a single automated manufacturing and repair cell. The methods, systems and processes of the present disclosure leverage unique software and hardware to configure a manufacturing cell that is capable of conducting process development and planning, dimensional analysis, pre-machining, surface preparation, cold spray (supersonic particle deposition), dust collection, helium recovery, and post machining in a single integrated manufacturing and repair cell.

公开(公告)号：US20190218410A1

公开(公告)日：2019-07-18

申请号：US16248371

申请日：2019-01-15

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： WILLIAM CROSS ,  JEEVAN MERUGA ,  JON KELLAR ,  P. STANLEY MAY ,  ARAVIND BARIDE

IPC: C09D11/50 ,  C09D11/38 ,  C09D11/322 ,  C09D11/023 ,  C09D11/037 ,  C09K11/77 ,  B41M3/14

CPC classification number: C09D11/50 ,  B41M3/144 ,  C09D11/023 ,  C09D11/037 ,  C09D11/322 ,  C09D11/38 ,  C09K11/7773

Abstract: The present technology relates generally to a stable oil-in-water emulsion containing upconverting nanoparticles. In particular, the present technology relates to an ink formulation comprising a stable oil-in-water emulsion of upconverting nanoparticles useful for security printing. Preferably the upconverting nanoparticles comprise a β-Na(RE)F4 nanoparticle, wherein RE is a lanthanide, yttrium, or a combination or mixture thereof.

公开(公告)号：US20190146580A1

公开(公告)日：2019-05-16

申请号：US16189653

申请日：2018-11-13

Applicant: South Dakota Board of Regents

Inventor： Lee Baugh ,  Kelene Fercho

IPC: G06F3/01 ,  A61B3/14 ,  A61B3/11

Abstract: The disclosed apparatus, systems and methods relate to pupillary assisted communication systems, devices and methods. A classification algorithm such as a hybrid classification algorithm is utilized to utilize at least one pupillary-response sensing device and at least one non-pupillary response sensing device to generate and process subject data to improve feedback systems and improve non-verbal communication and stimulus-response operations systems.

公开(公告)号：US10221117B2

公开(公告)日：2019-03-05

申请号：US15683890

申请日：2017-08-23

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： David A. Boyles ,  John T. Bendler ,  Tsvetanka Filipova

IPC: C08G63/02 ,  C07C39/367 ,  C07C39/42 ,  C08G64/10 ,  H01B3/42 ,  H01G4/18 ,  C07C43/295 ,  H01G4/32

Abstract: The present invention provides monomers, analogs, and/or derivatives of bisphenols substituted with one or more fluoromethyl groups. These monomers, analogs, and/or derivatives can be used to form oligomers and/or polymers, which in turn can be used to make compounds with dielectric properties suitable for dielectric materials, including for example, use in energy dense capacitors. In a preferred embodiment, the compounds can comprise a polycarbonate of a homopolymer, copolymer, and/or terpolymer of a bisphenol with one or more fluoromethyl substitution groups. In an aspect of the invention the compounds chosen can be selected based on various desired characteristics, including, for example, their energy density, glass transition temperature, dielectric loss, and/or dipole density.

公开(公告)号：US10197040B2

公开(公告)日：2019-02-05

申请号：US15466605

申请日：2017-03-22

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  Michigan Technological University ,  South Dakota Board of Regents

Inventor： Ossama Abdelkhalik ,  Rush D. Robinett, III ,  Shangyan Zou ,  Giorgio Bacelli ,  David G. Wilson ,  Umesh Korde

IPC: F03B13/16 ,  G05B19/406 ,  F03B15/00

Abstract: A wave energy converter and method for extracting energy from water waves maximizes the energy extraction per cycle by estimating an excitation force of heave wave motion on the buoy, computing a control force from the estimated excitation force using a dynamic model, and applying the computed control force to the buoy to extract energy from the heave wave motion. Analysis and numerical simulations demonstrate that the optimal control of a heave wave energy converter is, in general, in the form of a bang-singular-bang control; in which the optimal control at a given time can be either in the singular arc mode or in the bang-bang mode. The excitation force and its derivatives at the current time can be obtained through an estimator, for example, using measurements of pressures on the surface of the buoy in addition to measurements of the buoy position. A main advantage of this approximation method is the ease of obtaining accurate measurements for pressure on the buoy surface and for buoy position, compared to wave elevation measurements.

公开(公告)号：US20190015335A1

公开(公告)日：2019-01-17

申请号：US16034156

申请日：2018-07-12

Applicant: South Dakota Board of Regents

Inventor： Joshua Reineke ,  Mikhail Durymanov ,  Anastasia Permyakova

IPC: A61K9/14 ,  A61P39/00 ,  A61K31/275 ,  A61K31/704 ,  A61K9/51 ,  A61K31/357 ,  A61K31/655

Abstract: Compositions for targeted delivery of a protective agent to the liver, and systems and methods for administering the compositions are described. When administered prior to or in combination with one or more chemotherapeutic agents, the compositions containing the protective agent protect the liver without adversely affecting the efficacy of the chemotherapeutic agent(s). Additionally, the use of these compositions enables the administration of higher doses of the chemotherapeutic agent(s). The compositions contain particles, comprising nanoparticles, microparticles, or combinations thereof, which contain a hepatoprotective agent. The systems contain a first formulation comprising particles that contain a protective agent to the liver and a second formulation comprising a chemotherapeutic agent. The particles containing the hapatoprotective agent are short circulating particles.