公开(公告)号：US06413553B1

公开(公告)日：2002-07-02

申请号：US09925415

申请日：2001-08-10

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharaya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharaya

IPC: A61K3578

CPC classification number: A61K36/67

Abstract: A pharmaceutical formulation is provided which is useful as a leukotrine synthesis and IL4 inhibitor and as a Th1 immunomodulator. The formulation comprises an effective amount of a combination of extracts and lyophilized extracts of Piper betel and Murrya koeniggi. The formulation can be formulated with pharmaceutically acceptable carriers. The formulation can be used in a method of treating humans for respiratory conditions.

Abstract translation: 提供了可用作白细胞素合成和IL4抑制剂和作为Th1免疫调节剂的药物制剂。 该制剂包含有效量的Pi bet提取物和冻干提取物的混合物。 制剂可以用药学上可接受的载体配制。 该制剂可用于治疗人类呼吸状况的方法。

公开(公告)号：US09290473B2

公开(公告)日：2016-03-22

申请号：US13144263

申请日：2010-01-12

Applicant: Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

Inventor： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC: A61K31/36 ,  C07C215/54 ,  C07C255/33 ,  C07C39/10 ,  C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

CPC classification number: C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

Abstract: The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

Abstract translation: 本发明涉及用于通过抑制PI3-Akt途径和或诱导NO来治疗恶性肿瘤的通式1的化合物。 本发明还涉及通式1的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US09085559B2

公开(公告)日：2015-07-21

申请号：US13321445

申请日：2010-12-31

Applicant: Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

Inventor： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC: C07D403/14 ,  C07D251/50 ,  C07D251/52 ,  A61K31/53 ,  A61P11/06

CPC classification number: C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

Abstract: A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

Abstract translation: 属于“三嗪 - 芳基 - 双 - 吲哚”的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US20140135393A1

公开(公告)日：2014-05-15

申请号：US14110869

申请日：2012-04-11

Applicant: Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

Inventor： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC: C07C39/19 ,  C07C251/40 ,  C07D317/50 ,  C07C255/36 ,  C07C69/732 ,  C07C69/017 ,  C07C251/66

CPC classification number: C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

Abstract: The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

Abstract translation: 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US08029833B2

公开(公告)日：2011-10-04

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US07306817B2

公开(公告)日：2007-12-11

申请号：US10960064

申请日：2004-10-08

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A01N65/00

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water: methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用，组合物包含所述级分nos。 1和9。

公开(公告)号：US20070161704A1

公开(公告)日：2007-07-12

申请号：US11640401

申请日：2006-12-18

Applicant: Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

Inventor： Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

IPC: A61K31/235

CPC classification number: A61K31/235 ,  A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to a pharmaceutical composition useful for treating chronic myeloid leukemia where Bcr-Abl kinase is constitutively expressed in animals and humans, and a treatment of chronic myeloid leukemia (CML) by a composition comprising an effective amount of analogs and/or salts of chlorogenic acid. The analogs are preferably sodium chlorogenate (Na-Chl) or potassium or ammonium salts, which were prepared from Chlorogenic acid or its analogs.

Abstract translation: 本发明涉及一种用于治疗慢性骨髓性白血病的药物组合物，其中Bcr-Abl激酶在动物和人体中组成型表达，并且通过包含有效量的类似物和/或盐类型的组合物的组合物治疗慢性骨髓性白血病（CML） 绿原酸。 类似物优选由绿原酸或其类似物制备的氯酸钠（Na-Chl）或钾盐或铵盐。

公开(公告)号：US06967034B2

公开(公告)日：2005-11-22

申请号：US10448398

申请日：2003-05-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K36/67 ,  A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  Y10S514/908 ,  A61K2300/00

Abstract: A new herbal-based composition and method for treatment of CD33+ acute and chronic myeloid leukemia by Piper betel leaf extracts, and to provide a process for the isolation of active fractions from leaves or any other plant parts of Piper betel to treat CD33+ AML and CML with a simplified method of isolation of active components from all plant parts of Piper betel possessing biological activities relevant to the treatment of CD33+ AML and CML.

Abstract translation: 一种新的草药组合物和方法，用于通过per叶提取物治疗CD33 +急性和慢性骨髓性白血病，并提供从叶子或Piper槟榔的任何其他植物部分分离活性级分以处理CD33 + AML和CML的方法 采用简单的方法将活性成分从具有与治疗CD33 + AML和CML相关的生物活性的Piper槟榔的所有植物部分分离出来。

公开(公告)号：US20050089585A1

公开(公告)日：2005-04-28

申请号：US10960064

申请日：2004-10-08

Applicant: Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K36/00 ,  A61K36/67 ,  A61K35/78 ,  C12Q1/68

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: The present invention relates to a method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract translation: 本发明涉及使用级分nos处理包括人在内的动物中的CD33 +急性和慢性骨髓性白血病的方法。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从piper槟的极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用，组合物包含所述级分nos。 1和9。