公开(公告)号：US20120129135A1

公开(公告)日：2012-05-24

申请号：US12951455

申请日：2010-11-22

Applicant: JEN-CHANG Yang ,  Nai-Chia Teng ,  Chien-Chung Chen ,  Sheng-Yang Lee ,  Chen-Feng Ma ,  Dian-Yu Ji

Inventor： JEN-CHANG Yang ,  Nai-Chia Teng ,  Chien-Chung Chen ,  Sheng-Yang Lee ,  Chen-Feng Ma ,  Dian-Yu Ji

IPC: A61C19/06 ,  A61K8/02 ,  A61Q11/00 ,  A61K8/24

CPC classification number: A61Q11/00 ,  A61K8/0208 ,  A61K8/24 ,  A61K8/365

Abstract: The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: (Ca+2)x(anion−a)y(PO4−3)z wherein 2x=(a*y+3z); a is an integer of 1 to 3; and each of x, y and z is not 0.

Abstract translation: 本发明提供了一种含阴离子钙磷酸盐化合物，其组合物和牙科修补物及其在再矿化牙齿中的用途。 含阴离子的磷酸钙化合物具有下式：（Ca + 2）x（阴离子a）y（PO4-3）z其中2x =（a * y + 3z）; a为1〜3的整数， x，y和z中的每一个不为0。

公开(公告)号：US20110288273A1

公开(公告)日：2011-11-24

申请号：US12783818

申请日：2010-05-20

Applicant: Jen-Chang YANG ,  Sheng-Yang LEE ,  Chien Chung CHEN ,  Yun-Ting HSU ,  Hong-Da WU ,  Dian-Yu JI

Inventor： Jen-Chang YANG ,  Sheng-Yang LEE ,  Chien Chung CHEN ,  Yun-Ting HSU ,  Hong-Da WU ,  Dian-Yu JI

IPC: C07K1/30

CPC classification number: C07K14/43586

Abstract: The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%.

Abstract translation: 本发明涉及用于生产不需要透析的再生丝素蛋白的简单且高产率的方法。 特别地，本发明的方法的特征在于，通过施加剪切应力和/或改变丝心蛋白溶液的溶剂能力使丝素蛋白沉淀。 本发明的方法简化了生产丝素蛋白的过程，大大缩短了1至2小时的处理时间，而常规透析过程复杂，需要2至3天左右。 除了减少所需时间之外，本发明的方法可以将丝素蛋白的生产率提高至少8％。

公开(公告)号：US20110171600A1

公开(公告)日：2011-07-14

申请号：US12777504

申请日：2010-05-11

Applicant: Chung-Kuang Yang ,  Sea-Fue Wang ,  Sheng-Yang Lee ,  Jen-Chang Yang ,  I-lin Ho

Inventor： Chung-Kuang Yang ,  Sea-Fue Wang ,  Sheng-Yang Lee ,  Jen-Chang Yang ,  I-lin Ho

IPC: A61C8/00 ,  C25D5/00 ,  C23C14/00

CPC classification number: A61C8/0022 ,  A61C8/0015 ,  A61C2008/0046 ,  C25D11/26

Abstract: A bio-implant having a screw body selectively formed with nanoporous channels structure in a spiral groove and the method of making the same are disclosed. Nanoporous channels structure formed into the spiral groove of the bio-implant is carried out by the heat treatment in vacuum firstly and anodic treatment secondly. Thereafter, bioactive material is filled into the nanoporous and deposited on the implant surface by an electro-deposition process so as to increase the bioactivity and biocompatibility of the bio-implant.

Abstract translation: 公开了具有在螺旋槽中选择性地形成有纳米多孔通道结构的螺旋体的生物植入物及其制造方法。 通过在真空中的热处理进行生物植入物的螺旋槽中形成的纳米孔道结构，其次是阳极处理。 此后，将生物活性材料填充到纳米多孔中并通过电沉积方法沉积在植入物表面上，以增加生物植入物的生物活性和生物相容性。

公开(公告)号：US20100143271A1

公开(公告)日：2010-06-10

申请号：US12461942

申请日：2009-08-28

Applicant: Jen-Chang Yang ,  Dian-Yu Ji ,  Chien-Chung Chen ,  Haw-Ming Huang ,  Sheng-Yang Lee

Inventor： Jen-Chang Yang ,  Dian-Yu Ji ,  Chien-Chung Chen ,  Haw-Ming Huang ,  Sheng-Yang Lee

IPC: A61K8/21 ,  A61Q11/00 ,  C01B25/26

CPC classification number: A61K8/987 ,  A61K8/24 ,  A61Q11/00 ,  C01B25/32

Abstract: A method for preparing amorphous calcium phosphate (ACP) and oral care composition containing ACP prepared by the same are disclosed, wherein the method comprises the following steps: (a) cleaning and pulverizing the oyster shells; (b) sintering the oyster shells to obtain a calcium-containing powder; (c) dissolving the calcium-containing powder in water to obtain a calcium-containing solution; and (d) mixing the calcium-containing solution with a other phosphate-containing solution, to produce amorphous calcium phosphate.The method of the present invention not only can simplify the process and reduce the cost, but also can solve the problem of environment pollution resulting from wasted oyster shells. In addition, the ACP prepared in accordance with the method of the present invention further comprises some trace elements, such as strontium (Sr) and fluoride (F), which can improve dental health.

Abstract translation: 公开了一种制备无定形磷酸钙（ACP）的方法和含有由其制备的ACP的口腔护理组合物，其中该方法包括以下步骤：（a）清洗和粉碎牡蛎壳; （b）烧结牡蛎壳以获得含钙粉末; （c）将含钙粉末溶解在水中以得到含钙溶液; 和（d）将含钙溶液与其它含磷酸盐溶液混合，制成无定形磷酸钙。 本发明的方法不仅可以简化工艺，降低成本，而且可以解决蚝壳浪费造成环境污染的问题。 此外，根据本发明的方法制备的ACP还包含一些可以改善牙齿健康的微量元素，例如锶（Sr）和氟化物（F）。

公开(公告)号：US20100086474A1

公开(公告)日：2010-04-08

申请号：US12245644

申请日：2008-10-03

Applicant: Jen-Chang Yang ,  Hong-Da Wu ,  Nai-Chia Teng ,  Sheng-Yang Lee

Inventor： Jen-Chang Yang ,  Hong-Da Wu ,  Nai-Chia Teng ,  Sheng-Yang Lee

IPC: C01F11/46

CPC classification number: C01F11/46

Abstract: The invention provides a process for preparing α-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain α-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: −0.4x5+7.33x4−52.83x3+187.17x2−328.27x+316

Abstract translation: 本发明提供了一种制备α-硫酸钙半水合物的方法，包括以下步骤：将含有硫酸根离子和钙离子的水溶液加入到浓度范围的氯化钙溶液中; 使a）的混合物在一定温度范围内反应适当的时间; 过滤和洗涤b）的反应产物与上升溶剂分离固相和液相; 和d）收集和干燥固相以获得高纯度的α-硫酸钙半水合物; 其中氯化钙浓度范围（y）与反应温度（x）的范围之间的关系如下式所示：-0.4x5 + 7.33x4-52.83x3 + 187.17x2-328.27x + 316 < y <1.2x5-22x4 + 158.5x3-561.5x2 + 984.8x-588（2

公开(公告)号：US20120301436A1

公开(公告)日：2012-11-29

申请号：US13117477

申请日：2011-05-27

Applicant: JEN-CHANG YANG ,  SHENG-YANG LEE ,  HAW-MING HUANG ,  DIAN-YU JI ,  HONG-DA WU ,  CHEN-FENG MA

Inventor： JEN-CHANG YANG ,  SHENG-YANG LEE ,  HAW-MING HUANG ,  DIAN-YU JI ,  HONG-DA WU ,  CHEN-FENG MA

IPC: A61K35/12 ,  A61P13/00 ,  A61K38/02 ,  A61K38/18 ,  A61K47/42

CPC classification number: A61K9/10 ,  A61K9/0024 ,  A61K47/34 ,  A61K47/36

Abstract: The invention provides a polyelectrolyte complex gel comprising a chitosan and a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the γ-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmentation implant, comprising a polyelectrolyte complex gel of the invention as a carrier or a filler and an optional additive. The polyelectrolyte complex gel and the soft tissue augmentation implant containing the same has long degradation time and better supportability so as to provide good maintenance for soft tissue.

Abstract translation: 本发明提供一种包含分子量约1kDa至约400kDa的壳聚糖和γ-聚谷氨酸（γ-PGA）或其盐的聚电解质复合凝胶，其中壳聚糖和γ-PGA用 水溶液。 还提供了软组织增强植入物，其包含作为载体或填料的本发明的聚电解质复合物凝胶和任选的添加剂。 聚电解质复合凝胶和含有它的软组织增补植入物具有长的降解时间和更好的支撑性，从而为软组织提供良好的维护。

公开(公告)号：US5951292A

公开(公告)日：1999-09-14

申请号：US156617

申请日：1998-09-18

Applicant: Sheng Yang Lee ,  Haw Ming Huang ,  Ching Yi Lin

Inventor： Sheng Yang Lee ,  Haw Ming Huang ,  Ching Yi Lin

IPC: A61C19/04 ,  G01H1/12 ,  A61C5/00

CPC classification number: G01H1/12 ,  A61B9/00 ,  A61C19/04 ,  A61C19/041 ,  A61C19/043

Abstract: A method of detecting periodontal disease involves attaching a vibration detector to the tooth, causing the tooth to vibrate by means of striking the tooth with a hammer, and then picking up signals corresponding to of the vibration of the tooth for processing by a dynamic signal analyzer and a microprocessor using Fourier analysis. The location of the natural frequency of the tooth is determined based on the lowest point in the image mode and the point of contraflexure in the real mode.

Abstract translation: 一种检测牙周病的方法涉及将振动检测器附接到牙齿上，通过用锤敲击牙齿使牙齿振动，然后拾取与牙齿振动相对应的信号，以便通过动态信号分析仪 和使用傅立叶分析的微处理器。 基于图像模式中的最低点和实模式下的反射点确定牙齿固有频率的位置。