公开(公告)号：US5601999A

公开(公告)日：1997-02-11

申请号：US299414

申请日：1994-09-01

申请人： Takeshi Matsuzaki ,  Masato Nagaoka ,  Koji Nomoto ,  Shusuke Hashimoto ,  Teruo Yokokura

发明人： Takeshi Matsuzaki ,  Masato Nagaoka ,  Koji Nomoto ,  Shusuke Hashimoto ,  Teruo Yokokura

IPC分类号： A61K31/715 ,  A61K35/74 ,  A61P35/00 ,  C12P19/04 ,  C12P19/00

CPC分类号： C12P19/04 ,  A61K31/715 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747

摘要： An antitumor agent is provided by including, as an active ingredient, a polysaccharide-glycan complex obtained by treating a Gram-positive bacteria such as lactic acid bacteria and Bifidobacterium strains with a cell wall lytic enzyme produced by a bacterium belonging to the genus Achromobacter.The polysaccharide-glycan complex has no toxicity and causes no side effect. Being water-soluble, it is easily formulated into any arbitrary dose form, such as an injectable solution. It can easily be prepared from an easily available starting material.

摘要翻译： 提供抗肿瘤剂作为活性成分，通过用属于无色杆菌的细菌产生的细胞壁裂解酶处理革兰氏阳性菌如乳酸菌和双歧杆菌菌株获得的多糖 - 聚糖复合物。 多糖 - 聚糖复合物无毒性，不产生副作用。 易溶于水，容易配制成任意剂量形式，如可注射溶液。 它可以很容易地从容易获得的原料制备。

公开(公告)号：US09174979B2

公开(公告)日：2015-11-03

申请号：US13125698

申请日：2009-10-23

申请人： Takashi Ikeda ,  Seigo Sawada ,  Takashi Yaegashi ,  Takeshi Matsuzaki ,  Shusuke Hashimoto ,  Ryuta Yamazaki

发明人： Takashi Ikeda ,  Seigo Sawada ,  Takashi Yaegashi ,  Takeshi Matsuzaki ,  Shusuke Hashimoto ,  Ryuta Yamazaki

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P35/00 ,  C07D491/147

CPC分类号： C07D471/04 ,  C07D491/147

摘要： A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom;R2 represents a hydroxyl group, or a lower alkyloxy group;R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom;R4 represents a hydrogen atom or a lower alkyloxy group;R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6;R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5;R7 represents a hydrogen atom or a lower alkyl group; andR8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).

摘要翻译： 提供了具有优异的NF＆Kgr B抑制效果的新化合物，具体公开了下式（1）表示的化合物或其盐：其中，R1表示氢原子，低级烷基，低级烷氧基， 或卤素原子; R2表示羟基或低级烷氧基; R3表示氢原子，低级烷基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子，低级烷氧基，卤素原子，羟基或亚甲二氧基; R6表示与R5一起形成的氢原子，低级烷氧基或亚甲二氧基，或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; 并且R 8表示氢原子，羟基，氨基或低级烷基羰基氧基（R 1，R 3，R 4和R 7为氢原子的情况除外，R 2和R 8为羟基，R 5和R 6为甲氧基 ）。

公开(公告)号：US08701858B2

公开(公告)日：2014-04-22

申请号：US13532294

申请日：2012-06-25

申请人： Michiharu Iwamura ,  Yoshikatsu Mizushima ,  Shusuke Hashimoto

发明人： Michiharu Iwamura ,  Yoshikatsu Mizushima ,  Shusuke Hashimoto

IPC分类号： G07F7/04

CPC分类号： G07D11/0066 ,  G07D11/0063

摘要： A banknote handling apparatus is operable in a code management mode in which banknotes stored in a storage unit are managed based on codes of the banknotes read by a recognition unit, and in a count management mode in which the banknotes stored in the storage unit are managed by counting the number of the banknotes to be stored in the storage unit. The banknote handling apparatus is switchable between the code management mode and the count management mode.

摘要翻译： 纸币处理装置可以在代码管理模式下操作，其中存储在存储单元中的纸币基于由识别单元读取的纸币的代码进行管理，并且在存储在存储单元中的纸币被管理的计数管理模式 通过计数要存储在存储单元中的纸币的数量。 纸币处理装置可以在代码管理模式和计数管理模式之间切换。

公开(公告)号：US20050130934A1

公开(公告)日：2005-06-16

申请号：US11049423

申请日：2005-02-02

申请人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

发明人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Takagi ,  Shusuke Hashimoto

IPC分类号： A61K31/731 ,  A61K31/737 ,  C08B37/00

CPC分类号： A61K31/702 ,  A61K31/731 ,  A61K31/737

摘要： An antibacterial agent showing a high affinity for Helicobactor pyroli and having an antibacterial effect specific to H. Pyroli. The agent has a chemical structure wherein an antibacterial substance is bonded to a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide. Preferable embodiments are those having the chemical structure represented by Y—OCH(AH2NHR)n or Y—BH2NHR, wherein Y represents a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide; A a carbon derived from aldehyde group occurring through the reduction of the reduced end sugar of Y and subsequent oxidation of the resulting product with an oxidant; B a carbon derived from the aldehyde group at the reduced end sugar of Y; R an antibacterial substance with a primary amino group or with an amino group introduced therein or represents an antibacterial substance derivative prepared by bonding an antibacterial substance through a spacer to the carbon A or the carbon B; and n=1 or 2.

摘要翻译： 对Helicobactor pyroli具有高亲和力并具有对H. Pyroli特异性的抗菌作用的抗菌剂。 该药剂具有抗菌物质与通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖结合的化学结构。 优选的实施方案是具有由Y-OCH（AHN 2 NHR）n或Y-BH 2 NHR表示的化学结构的那些，其中Y表示 通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖; 衍生自醛基的碳通过还原末端糖的Y而发生，随后用氧化剂氧化所得产物; B是衍生自Y的还原末端糖的醛基的碳; R是具有伯氨基或在其中引入氨基的抗菌物质，或代表通过间隔剂将抗菌物质与碳A或碳B结合而制备的抗菌物质衍生物; n = 1或2。

公开(公告)号：US5475089A

公开(公告)日：1995-12-12

申请号：US75545

申请日：1993-06-14

申请人： Osamu Matsuo ,  Masashi Sakai ,  Kisaku Shimura ,  Hiroshi Sansawa ,  Tsunekazu Watanabe ,  Tsuneo Matsumoto ,  Yoshiyuki Shishido ,  Shusuke Hashimoto ,  Teruo Yokokura ,  Masaharu Onoue ,  Tomoyuki Sako

发明人： Osamu Matsuo ,  Masashi Sakai ,  Kisaku Shimura ,  Hiroshi Sansawa ,  Tsunekazu Watanabe ,  Tsuneo Matsumoto ,  Yoshiyuki Shishido ,  Shusuke Hashimoto ,  Teruo Yokokura ,  Masaharu Onoue ,  Tomoyuki Sako

IPC分类号： A61K38/46 ,  C07K14/31 ,  C12N9/52 ,  A61K38/43 ,  C07K14/00

CPC分类号： C07K14/31

摘要： A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.

摘要翻译： PCT No.PCT / JP91 / 01722 Sec。 371日期：1993年6月14日 102（e）日期1993年6月14日PCT 1991年12月17日PCT公布。 出版物WO92 / 11356 日期：1992年7月9日。一种由136个氨基酸残基组成的血栓溶解肽，与葡萄球菌激酶（SAK）相比，其抗原性问题很小，仅有小剂量有效。 通过使用胰蛋白酶蛋白酶切割不影响SAK活性的氨基酸或肽来获得该肽。 特别地，通过在SAK的N末端切割由10个氨基酸残基构成的肽获得的SAK-11在纤维蛋白溶解，纤溶酶原激活和纤维蛋白特异性方面优于SAK。