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公开(公告)号：US5601999A
公开(公告)日：1997-02-11
申请号：US299414
申请日：1994-09-01
IPC分类号： A61K31/715 , A61K35/74 , A61P35/00 , C12P19/04 , C12P19/00
CPC分类号： C12P19/04 , A61K31/715 , A61K35/744 , A61K35/745 , A61K35/747
摘要： An antitumor agent is provided by including, as an active ingredient, a polysaccharide-glycan complex obtained by treating a Gram-positive bacteria such as lactic acid bacteria and Bifidobacterium strains with a cell wall lytic enzyme produced by a bacterium belonging to the genus Achromobacter.The polysaccharide-glycan complex has no toxicity and causes no side effect. Being water-soluble, it is easily formulated into any arbitrary dose form, such as an injectable solution. It can easily be prepared from an easily available starting material.
摘要翻译： 提供抗肿瘤剂作为活性成分，通过用属于无色杆菌的细菌产生的细胞壁裂解酶处理革兰氏阳性菌如乳酸菌和双歧杆菌菌株获得的多糖 - 聚糖复合物。 多糖 - 聚糖复合物无毒性，不产生副作用。 易溶于水，容易配制成任意剂量形式，如可注射溶液。 它可以很容易地从容易获得的原料制备。
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公开(公告)号：US10174386B2
公开(公告)日：2019-01-08
申请号：US11814579
申请日：2006-01-30
IPC分类号： C12Q1/68 , C12Q1/689 , C12Q1/6844 , C12Q1/6851
摘要： An object of the present invention is to provide a method of quantitating or detecting a microorganism, capable of detecting a live microorganism at high sensitivity and more precisely. A method of quantitating a microorganism of interest, using as an index the amount of rRNA of the microorganism of interest is provided.
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公开(公告)号：US20090253643A1
公开(公告)日：2009-10-08
申请号：US12092355
申请日：2006-11-02
申请人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
IPC分类号： A61K31/7032 , C07C31/18 , C07H3/02 , C07H15/00 , C07H3/06 , C07H3/04 , C07C35/16 , A61K31/047 , A61K31/7004 , A61K31/702 , A61K31/7016 , A61P5/00 , C12N1/00 , C12Q1/04
CPC分类号： C12Q1/04 , A23L5/00 , A23L21/00 , A23L27/33 , A23L29/30 , A23L29/37 , A23L33/125 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/702
摘要： An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equal in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equal and a method of detecting the same. Provided are an equal concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equal concentration-raising or reducing agent; a method of raising or reducing the concentration of equal by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equal; and a method of detecting a microorganism having conversion ability to equal by use of the selective medium.
摘要翻译： 发明内容本发明的目的在于提供一种具有调节体内相同浓度并且能够长期耐受高安全性的药物，食品和饮料，并为具有转化能力的微生物提供选择性培养基 以及相同的检测方法。 提供含有碳水化合物作为活性成分的等浓度升高或还原剂; 使用碳水化合物制备等浓度升高或还原剂; 通过以有效剂量施用碳水化合物来提高或降低相等浓度的方法; 含有转化能力相等的微生物碳水化合物的选择培养基; 以及通过使用选择培养基检测具有相等转化能力的微生物的方法。
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公开(公告)号：US20110318309A1
公开(公告)日：2011-12-29
申请号：US13203144
申请日：2010-02-25
申请人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
IPC分类号： A61K35/74 , C12P17/06 , C07H21/04 , A61P15/00 , A61P3/06 , A61P19/10 , A61P9/10 , C12N1/20 , A61P35/00
CPC分类号： C12R1/01 , A23L33/105 , A61K31/7048 , A61K35/74 , C12P17/06
摘要： The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
摘要翻译： 本发明涉及在50％以上的24小时内将大豆黄素转化为雌马酚的能力的微生物; 含有微生物的食品/饮料或药物组合物; 使用微生物的雌马酚生产方法; 以及能够特异性检测微生物的核酸片段。
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公开(公告)号：US09080197B2
公开(公告)日：2015-07-14
申请号：US12092355
申请日：2006-11-02
申请人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
IPC分类号： A61K31/7004 , A61K31/702 , A61K31/047 , A61P5/00 , C12Q1/04 , A23L1/09 , A23L1/236 , A61K31/7016
CPC分类号： C12Q1/04 , A23L5/00 , A23L21/00 , A23L27/33 , A23L29/30 , A23L29/37 , A23L33/125 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/702
摘要： An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equol in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equol and a method of detecting the same. Provided are an equol concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equol concentration-raising or reducing agent; a method of raising or reducing the concentration of equol by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equol; and a method of detecting a microorganism having conversion ability to equol by use of the selective medium.
摘要翻译： 本发明的目的在于提供一种能够在体内调节雌马酚的浓度，能够长时间高安全性地使用的药物，食品和饮料，具有转化能力的微生物的选择性培养基 至雌马酚及其检测方法。 提供含有碳水化合物作为活性成分的雌马酚浓度升高或还原剂; 使用碳水化合物制备雌马酚浓度升高或还原剂; 通过以有效剂量施用碳水化合物来提高或降低雌马酚的浓度的方法; 一种选择性培养基，其含有具有对牛尿酚转化能力的微生物的碳水化合物; 以及通过使用选择性培养基检测具有牛尿酚转化能力的微生物的方法。
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公开(公告)号：US08420073B2
公开(公告)日：2013-04-16
申请号：US13203144
申请日：2010-02-25
申请人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
CPC分类号： C12R1/01 , A23L33/105 , A61K31/7048 , A61K35/74 , C12P17/06
摘要： The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
摘要翻译： 本发明涉及在50％以上的24小时内将大豆黄素转化为雌马酚的能力的微生物; 含有微生物的食品/饮料或药物组合物; 使用微生物的雌马酚生产方法; 以及能够特异性检测微生物的核酸片段。
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公开(公告)号：US20090170078A1
公开(公告)日：2009-07-02
申请号：US11814579
申请日：2006-01-30
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6844 , C12Q1/6851
摘要： An object of the present invention is to provide a method of quantitating or detecting a microorganism, capable of detecting a live microorganism at high sensitivity and more precisely. A method of quantitating a microorganism of interest, using as an index the amount of rRNA of the microorganism of interest is provided.
摘要翻译： 本发明的目的是提供一种能够以高灵敏度和更精确地检测活微生物的微生物的定量或检测方法。 提供了使用感兴趣的微生物的rRNA的量作为指标来定量感兴趣的微生物的方法。
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