Patent search ap:"Siegfried Heinz Reich" Page 3

21.

发明授权
Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 失效
Title translation: 吲唑化合物，药物组合物和介导或抑制细胞增殖的方法

公开(公告)号：US06919461B2

公开(公告)日：2005-07-19

申请号：US10291158

申请日：2002-11-08

Applicant: Siegfried Heinz Reich , Ted Michael Bleckman , Susan Elizabeth Kephart , William Henry Romines , Michael B. Wallace

Inventor： Siegfried Heinz Reich , Ted Michael Bleckman , Susan Elizabeth Kephart , William Henry Romines , Michael B. Wallace

IPC: B22D11/10 , A61K31/416 , A61K31/4184 , A61K31/4375 , A61K31/443 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/00 , A61P35/00 , A61P43/00 , B22D41/50 , B22D41/56 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D521/00

CPC classification number: C07D249/08 , B22D41/56 , C07D231/12 , C07D231/56 , C07D233/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07F7/1804

Abstract: Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract translation: 描述了调节和/或抑制细胞增殖的吲唑化合物，例如蛋白激酶的活性。这些化合物和含有它们的药物组合物能够介导例如激酶依赖性疾病以调节和/或抑制不期望的细胞增殖。本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管发生和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎和牛皮癣，通过施用有效量的这种化合物。

22.

发明授权
Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation 失效
Title translation: 噻唑苯甲酰胺衍生物和抑制细胞增殖的药物组合物

公开(公告)号：US06720346B2

公开(公告)日：2004-04-13

申请号：US10190219

申请日：2002-07-05

Applicant: Shao Song Chu , Larry Andrew Alegria , Ted Michael Bleckman , Wesley Kwan Mung Chong , Rohit K. Duvadie , Lin Li , Siegfried Heinz Reich , William Henry Romines, III , Michael B. Wallace , Yi Yang

Inventor： Shao Song Chu , Larry Andrew Alegria , Ted Michael Bleckman , Wesley Kwan Mung Chong , Rohit K. Duvadie , Lin Li , Siegfried Heinz Reich , William Henry Romines, III , Michael B. Wallace , Yi Yang

IPC: A61K31425

CPC classification number: C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/12 , C07D491/10

Abstract: Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

Abstract translation: 描述了具有单 - 二取代苯甲酰胺的氨基噻唑化合物由式（I）表示，并且描述了其药学上可接受的盐，药学上可接受的前药，药学活性代谢物和所述代谢物的药学上可接受的盐。这些试剂调节和/或抑制蛋白激酶的细胞增殖和活性，并且可用作治疗恶性肿瘤和其它疾病的药物。

23.

发明授权
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use 有权

公开(公告)号：US06534524B1

公开(公告)日：2003-03-18

申请号：US09983783

申请日：2001-10-25

Applicant: Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins

Inventor： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins

IPC: C07D40302

CPC classification number: C07D401/12 , C07D209/18 , C07D401/14 , C07D403/12

Abstract: Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

24.

发明授权
HIV protease inhibitors 失效
Title translation: HIV蛋白酶抑制剂

公开(公告)号：US06525215B2

公开(公告)日：2003-02-25

申请号：US09885056

申请日：2001-06-21

Applicant: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez

Inventor： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez

IPC: C07C6532

CPC classification number: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62

Abstract: Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula:

Abstract translation: 可用作制备HIV蛋白酶抑制剂的中间体的化合物。这些化合物具有以下通式：

25.

发明授权
HIV protease inhibitors 失效
Title translation: HIV蛋白酶抑制剂

公开(公告)号：US06271235B1

公开(公告)日：2001-08-07

申请号：US08478600

申请日：1995-06-07

Applicant: Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim

Inventor： Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim

IPC: A61K31495

CPC classification number: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62

Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

Abstract translation: 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。